Reactome | KIT mutants:PI3K catalyze synthesis of PIP3

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KIT mutants:PI3K catalyze synthesis of PIP3 Show undefined attributes

authored	[InstanceEdit:9681395] Rothfels, Karen, 2020-04-01
catalystActivity	[CatalystActivity:9670406] 1-phosphatidylinositol-3-kinase activity of PI3K:p-KIT mutant dimers [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:9670432] Rothfels, Karen, 2019-12-09
crossReference	[DatabaseIdentifier:12667417] RHEA:21292 [DatabaseIdentifier:12020745] Mondo:0004992
dbId	9670433
disease	[Disease:1500689] cancer
displayName	KIT mutants:PI3K catalyze synthesis of PIP3
edited	[InstanceEdit:9686618] Rothfels, Karen, 2020-05-04
entityFunctionalStatus	[EntityFunctionalStatus:9670395] gain_of_function of PI3K:p-KIT mutant dimers [plasma membrane]
eventOf	[Pathway:R-HSA-9670439] Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9669213] KIT mutations are common in testicular seminomas [LiteratureReference:9669177] KIT (c-kit oncogene product) pathway is constitutively activated in human testicular germ cell tumors [LiteratureReference:9680307] KIT oncogenic signaling mechanisms in imatinib-resistant gastrointestinal stromal tumor: PI3-kinase/AKT is a crucial survival pathway [LiteratureReference:9680303] Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs) [LiteratureReference:9680542] Therapeutic effect of imatinib in gastrointestinal stromal tumors: AKT signaling dependent and independent mechanisms [LiteratureReference:9680290] Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor [LiteratureReference:9669094] Complementary activity of tyrosine kinase inhibitors against secondary kit mutations in imatinib-resistant gastrointestinal stromal tumours [LiteratureReference:9669245] Stem cell factor receptor/c-Kit: from basic science to clinical implications
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	KIT mutants:PI3K catalyze synthesis of PIP3
normalReaction	[Reaction:R-HSA-1433514] Synthesis of PIP3 from PIP2 by PI3K
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9670431] Phosphorylated KIT mutants bind PI3K - Homo sapiens
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9678239] Serrano, C�sar, 2020-03-13 [InstanceEdit:9678232] Garc�a-Valverde, Alfonso, 2020-03-13 [InstanceEdit:9678237] Pilco-Janeta, Daniel, 2020-03-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9670433
summation	[Summation:9670511] PI3K/AKT signaling is initiated downstream of KIT juxtamembr...

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(hasEvent)

[Pathway:R-HSA-9670439] Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants