Reactome | PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane

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PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane Show undefined attributes

catalystActivity	[CatalystActivity:10495917] phosphatidylinositol-4,5-bisphosphate phospholipase C activity of PLCbz [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10495919
displayName	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane
eventOf	[Pathway:R-SSC-1855204] Synthesis of IP3 and IP4 in the cytosol - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-1855174] I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol - Sus scrofa [Reaction:R-SSC-1855222] I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane - Sus scrofa [Reaction:R-SSC-198314] DAG stimulates protein kinase C-delta - Sus scrofa [Reaction:R-SSC-1855190] I(1,4,5)P3 transports from the cytosol to the nucleus - Sus scrofa
inferredFrom	[Reaction:R-HSA-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane
output	[SimpleEntity:R-ALL-114519] DAG [plasma membrane] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-114520] I(1,4,5)P3 [cytosol]
precedingEvent	[Reaction:R-SSC-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane - Sus scrofa [Reaction:R-SSC-199456] PTEN dephosphorylates PIP3 - Sus scrofa [Reaction:R-SSC-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-1855177
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-1855204] Synthesis of IP3 and IP4 in the cytosol
(precedingEvent)	[Reaction:R-SSC-1855174] I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol [Reaction:R-SSC-1855222] I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane [Reaction:R-SSC-198314] DAG stimulates protein kinase C-delta [Reaction:R-SSC-1855190] I(1,4,5)P3 transports from the cytosol to the nucleus
(inferredTo)	[Reaction:R-HSA-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane