Reactome | DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2

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DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 Show undefined attributes

authored	[InstanceEdit:3640727] Rothfels, K, 2013-05-29
catalystActivity	[CatalystActivity:3772432] 1-phosphatidylinositol-4-phosphate 5-kinase activity of ppDVL:PIP5K1B [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:3772437] Rothfels, K, 2013-06-24
crossReference	[DatabaseIdentifier:12667418] RHEA:14425
dbId	3772436
displayName	DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
eventOf	[Pathway:R-HSA-201688] WNT mediated activation of DVL - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-392417] PI4P [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3772379] Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation [LiteratureReference:2130277] Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation [LiteratureReference:208391] Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP [LiteratureReference:3772354] Regulation of phosphatidylinositol kinases and metabolism by Wnt3a and Dvl
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2
orthologousEvent	[Reaction:R-CEL-3772436] DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 - Caenorhabditis elegans [Reaction:R-DME-3772436] DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 - Drosophila melanogaster [Reaction:R-GGA-3772436] DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 - Gallus gallus [Reaction:R-XTR-3772436] DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 - Xenopus tropicalis [Reaction:R-SSC-3772436] DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 - Sus scrofa [Reaction:R-BTA-3772436] DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 - Bos taurus [Reaction:R-CFA-3772436] DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 - Canis familiaris [Reaction:R-RNO-3772436] DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 - Rattus norvegicus [Reaction:R-MMU-3772436] DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-3772434] Phosphorylated DVL recruits PIP5K1B to the plasma membrane - Homo sapiens
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3772436
summation	[Summation:3772431] Stimulation of the WNT pathway controls the activity of PIP5...

Referrals

(hasEvent)

[Pathway:R-HSA-201688] WNT mediated activation of DVL