Reactome | FGFR1-associated PI3K phosphorylates PIP2 to PIP3

Schema > Reaction > Entries

FGFR1-associated PI3K phosphorylates PIP2 to PIP3 Show undefined attributes

authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
catalystActivity	[CatalystActivity:5654685] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5654691] Rothfels, Karen, 2014-12-03
crossReference	[DatabaseIdentifier:12667417] RHEA:21292
dbId	5654690
deleted	[Deleted:5655535] Deletion of instance: 1268240
diseaseReaction	[Reaction:R-HSA-5655290] Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-1839107] BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-1839091] Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens
displayName	FGFR1-associated PI3K phosphorylates PIP2 to PIP3
eventOf	[Pathway:R-HSA-5654689] PI-3K cascade:FGFR1 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	FGFR1-associated PI3K phosphorylates PIP2 to PIP3
orthologousEvent	[Reaction:R-SSC-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 - Sus scrofa [Reaction:R-CEL-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 - Caenorhabditis elegans [Reaction:R-DME-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 - Drosophila melanogaster [Reaction:R-GGA-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 - Gallus gallus [Reaction:R-XTR-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 - Xenopus tropicalis [Reaction:R-DRE-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 - Danio rerio [Reaction:R-BTA-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 - Bos taurus [Reaction:R-CFA-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 - Canis familiaris [Reaction:R-RNO-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 - Rattus norvegicus [Reaction:R-MMU-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-5654591] Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5654690
summation	[Summation:1268237] Once recruited to the membrane, PI3K catalyzes the phosphory...

Referrals

(replacementInstances)	[Deleted:5655535] Deletion of instance: 1268240
(normalReaction)	[Reaction:R-HSA-5655290] Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-HSA-1839107] BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-HSA-1839091] Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3
(hasEvent)	[Pathway:R-HSA-5654689] PI-3K cascade:FGFR1