Reactome | BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate

Schema > Reaction > Entries

BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate Show undefined attributes

catalystActivity	[CatalystActivity:10151051] C-type glycerophospholipase activity of BLNK (SLP-65) Signalosome [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10151053
displayName	BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
eventOf	[Pathway:R-RNO-983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-1168373] PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-1112666] BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate - Homo sapiens
input	[SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
output	[SimpleEntity:R-ALL-114519] DAG [plasma membrane] [SimpleEntity:R-ALL-114520] I(1,4,5)P3 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-1112666
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-RNO-1168373] PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine
(hasEvent)	[Pathway:R-RNO-983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
(inferredTo)	[Reaction:R-HSA-1112666] BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate

Cite Us!