Reactome | PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR

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PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR Show undefined attributes

authored	[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
catalystActivity	[CatalystActivity:9672165] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of p-11Y PDGFR mutant dimers:PI3K [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9672161] Rothfels, Karen, 2019-12-23
crossReference	[DatabaseIdentifier:12667417] RHEA:21292 [DatabaseIdentifier:12020745] Mondo:0004992
dbId	9672177
disease	[Disease:1500689] cancer
displayName	PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR
edited	[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
entityFunctionalStatus	[EntityFunctionalStatus:9672144] gain_of_function of p-11Y PDGFR mutant dimers:PI3K [plasma membrane]
eventOf	[Pathway:R-HSA-9673767] Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9671898] PDGFRA activating mutations in gastrointestinal stromal tumors [LiteratureReference:9673503] Different inhibitory effect of imatinib on phosphorylation of mitogen-activated protein kinase and Akt and on proliferation in cells expressing different types of mutant platelet-derived growth factor receptor-alpha [LiteratureReference:9673539] Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas [LiteratureReference:9673518] Gastrointestinal stromal tumours: origin and molecular oncology [LiteratureReference:9676091] Constitutive activation of oncogenic PDGFR?-mutant proteins occurring in GIST patients induces receptor mislocalisation and alters PDGFR? signalling characteristics
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR
normalReaction	[Reaction:R-HSA-186800] PI3K catalyses the phosphorylation of PIP2 to PIP3
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9672172] PI3-kinase binds to mutant PDGFR receptor - Homo sapiens
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9676030] Ip, Carman K M, 2020-02-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9672177
summation	[Summation:9673744] PI3K/AKT signaling is initiated downstream of PDGFRA gain-of...

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(hasEvent)

[Pathway:R-HSA-9673767] Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants

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