Reactome | EPOR-associated PI3K phosphorylates PIP2 to PIP3

Schema > Reaction > Entries

EPOR-associated PI3K phosphorylates PIP2 to PIP3 Show undefined attributes

authored	[InstanceEdit:9021625] May, Bruce, 2017-08-30
catalystActivity	[CatalystActivity:9021624] phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PI3K bound to EPOR [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9021626] May, Bruce, 2017-09-19
crossReference	[DatabaseIdentifier:11880459] Rhea:21292
dbId	9021627
displayName	EPOR-associated PI3K phosphorylates PIP2 to PIP3
edited	[InstanceEdit:9021625] May, Bruce, 2017-08-30
eventOf	[Pathway:R-HSA-9027276] Erythropoietin activates Phosphoinositide-3-kinase (PI3K) - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9012635] Src transduces erythropoietin-induced differentiation signals through phosphatidylinositol 3-kinase [LiteratureReference:9012633] PI3 kinase is important for Ras, MEK and Erk activation of Epo-stimulated human erythroid progenitors [LiteratureReference:9027107] Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	EPOR-associated PI3K phosphorylates PIP2 to PIP3
orthologousEvent	[Reaction:R-DME-9021627] EPOR-associated PI3K phosphorylates PIP2 to PIP3 - Drosophila melanogaster [Reaction:R-XTR-9021627] EPOR-associated PI3K phosphorylates PIP2 to PIP3 - Xenopus tropicalis [Reaction:R-SSC-9021627] EPOR-associated PI3K phosphorylates PIP2 to PIP3 - Sus scrofa [Reaction:R-BTA-9021627] EPOR-associated PI3K phosphorylates PIP2 to PIP3 - Bos taurus [Reaction:R-CFA-9021627] EPOR-associated PI3K phosphorylates PIP2 to PIP3 - Canis familiaris [Reaction:R-RNO-9021627] EPOR-associated PI3K phosphorylates PIP2 to PIP3 - Rattus norvegicus [Reaction:R-MMU-9021627] EPOR-associated PI3K phosphorylates PIP2 to PIP3 - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9012657] EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K - Homo sapiens [Reaction:R-HSA-9027280] EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K - Homo sapiens [Reaction:R-HSA-9027275] EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K - Homo sapiens
releaseDate	2018-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9616793] McGraw, Kathy L, 2018-08-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9021627
summation	[Summation:9030343] Phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K) associ...

Referrals

(hasEvent)

[Pathway:R-HSA-9027276] Erythropoietin activates Phosphoinositide-3-kinase (PI3K)