Reactome | Initial binding of AP-2 and clathrin to PI(4,5)P2

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Initial binding of AP-2 and clathrin to PI(4,5)P2 Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10896416
displayName	Initial binding of AP-2 and clathrin to PI(4,5)P2
eventOf	[Pathway:R-DME-8856828] Clathrin-mediated endocytosis - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 - Homo sapiens
input	2 × [Complex:R-DME-167712] AP-2 Complex [cytosol] [Complex:R-DME-350827] Clathrin Triskelion [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Initial binding of AP-2 and clathrin to PI(4,5)P2
output	[Complex:R-DME-8871153] PI(4,5)P2:AP-2:clathrin [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-8871196
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-8856828] Clathrin-mediated endocytosis
(inferredTo)	[Reaction:R-HSA-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2

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