Reactome | Activated Ntrk2 activates PI3K signaling

Schema > BlackBoxEvent > Entries

authored	[InstanceEdit:9034391] Orlic-Milacic, Marija, 2018-01-05
catalystActivity	[CatalystActivity:9031554] 1-phosphatidylinositol-3-kinase activity of Bdnf,Ntf4:p-5Y-Ntrk2 homodimer:Gab1:Pik3ca:Pik3r1 [plasma membrane]
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9031552] Orlic-Milacic, Marija, 2017-11-30
dbId	9031553
displayName	Activated Ntrk2 activates PI3K signaling
edited	[InstanceEdit:9037703] Orlic-Milacic, Marija, 2018-02-20
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9028515] Impairment of TrkB-PSD-95 signaling in Angelman syndrome
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated Ntrk2 activates PI3K signaling
orthologousEvent	[BlackBoxEvent:R-HSA-9028519] NTRK2-activated PI3K generates PIP3 - Homo sapiens
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9037707] Antila, Hanna, 2018-02-13 [InstanceEdit:9037710] Castr�n, Eero, 2018-02-13
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-9031553
summation	[Summation:9031557] Mouse Ntrk2 (TrkB), activated by Bdnf or, possibly, by Ntf4 ...

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