Reactome | PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1

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PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 Show undefined attributes

authored	[InstanceEdit:1972373] Orlic-Milacic, M, 2011-11-04
catalystActivity	[CatalystActivity:1306978] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1306977] Orlic-Milacic, Marija, 2011-05-27
crossReference	[DatabaseIdentifier:12667417] RHEA:21292
dbId	1306979
displayName	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
edited	[InstanceEdit:1972361] Matthews, L, 2011-11-07
eventOf	[Pathway:R-HSA-1963642] PI3K events in ERBB2 signaling - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1250369] A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
orthologousEvent	[Reaction:R-CEL-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 - Caenorhabditis elegans [Reaction:R-DME-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 - Drosophila melanogaster [Reaction:R-GGA-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 - Gallus gallus [Reaction:R-XTR-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 - Xenopus tropicalis [Reaction:R-DRE-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 - Danio rerio [Reaction:R-SSC-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 - Sus scrofa [Reaction:R-BTA-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 - Bos taurus [Reaction:R-CFA-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 - Canis familiaris [Reaction:R-RNO-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 - Rattus norvegicus [Reaction:R-MMU-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-1250346] Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1972347] Neckers, LM, 2011-11-11 [InstanceEdit:1972346] Xu, W, 2011-11-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1306979
summation	[Summation:1358766] Active PI3K in complex with phosphorylated ERBB2:ERBB4cyt1 h...

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(hasEvent)

[Pathway:R-HSA-1963642] PI3K events in ERBB2 signaling