Reactome | FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3

Schema > Reaction > Entries

FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 Show undefined attributes

catalystActivity	[CatalystActivity:10615167] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10615169
displayName	FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
eventOf	[Pathway:R-DRE-5654720] PI-3K cascade:FGFR4 - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5654714] FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent	[Reaction:R-DRE-5654669] Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-5654714
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-5654720] PI-3K cascade:FGFR4
(inferredTo)	[Reaction:R-HSA-5654714] FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3

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