Reactome | PIP5K1C phosphorylates PI(4)P to PI(4,5)P2

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PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 Show undefined attributes

authored	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
catalystActivity	[CatalystActivity:8868067] 1-phosphatidylinositol-4-phosphate 5-kinase activity of PIP5K1C [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8868065] Rothfels, Karen, 2016-04-18
crossReference	[DatabaseIdentifier:12667418] RHEA:14425
dbId	8868066
displayName	PIP5K1C phosphorylates PI(4)P to PI(4,5)P2
edited	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
eventOf	[Pathway:R-HSA-8856828] Clathrin-mediated endocytosis - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-392417] PI4P [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1660523] Phosphoinositides in cell regulation and membrane dynamics [LiteratureReference:8868023] Stimulation of phosphatidylinositol kinase type I-mediated phosphatidylinositol (4,5)-bisphosphate synthesis by AP-2mu-cargo complexes [LiteratureReference:8868032] Type Igamma661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis [LiteratureReference:8867986] Clathrin regulates the association of PIPKIgamma661 with the AP-2 adaptor beta2 appendage [LiteratureReference:8867983] BAR domain scaffolds in dynamin-mediated membrane fission
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	PIP5K1C phosphorylates PI(4)P to PI(4,5)P2
orthologousEvent	[Reaction:R-PFA-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Plasmodium falciparum [Reaction:R-SCE-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Saccharomyces cerevisiae [Reaction:R-SPO-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Schizosaccharomyces pombe [Reaction:R-DDI-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Dictyostelium discoideum [Reaction:R-CEL-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Caenorhabditis elegans [Reaction:R-DME-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Drosophila melanogaster [Reaction:R-GGA-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Gallus gallus [Reaction:R-XTR-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Xenopus tropicalis [Reaction:R-SSC-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Sus scrofa [Reaction:R-BTA-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Bos taurus [Reaction:R-CFA-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Canis familiaris [Reaction:R-RNO-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Rattus norvegicus [Reaction:R-MMU-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-8856808] Recruitment of AP-2 complex and clathrin - Homo sapiens
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8870617] Antonescu, Costin N, 2016-05-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8868066
summation	[Summation:8868057] Plasma membrane enrichment of PI(4,5)P2 is maintained in par...

Referrals

(hasEvent)

[Pathway:R-HSA-8856828] Clathrin-mediated endocytosis

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