Reactome | Activated Ntrk3 stimulates PI3K activity

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Activated Ntrk3 stimulates PI3K activity Show undefined attributes

authored	[InstanceEdit:9034018] Orlic-Milacic, Marija, 2018-01-02
catalystActivity	[CatalystActivity:9603470] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Pik3ca:Pik3r1 [cytosol]
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9616943] Orlic-Milacic, Marija, 2018-08-15
dbId	9616944
deleted	[Deleted:9616948] Deletion of instance: 9603466
displayName	Activated Ntrk3 stimulates PI3K activity
edited	[InstanceEdit:9608101] Orlic-Milacic, Marija, 2018-05-09
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isChimeric	true
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9603384] The chimeric protein tyrosine kinase ETV6-NTRK3 requires both Ras-Erk1/2 and PI3-kinase-Akt signaling for fibroblast transformation [LiteratureReference:9603388] c-Src is required for tropomyosin receptor kinase C (TrkC)-induced activation of the phosphatidylinositol 3-kinase (PI3K)-AKT pathway
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated Ntrk3 stimulates PI3K activity
orthologousEvent	[BlackBoxEvent:R-HSA-9603445] Activated NTRK3 stimulates PI3K activity - Homo sapiens
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
regulatedBy	[PositiveRegulation:9603472] Positive regulation by 'bNTF3:p-5Y-Ntrk3 homodimer:MyrG-p-Y424-Src,(bNTF3:p-5Y-Ntrk3 homodimer,bNTF3:p-5Y-Ntrk3 homodimer:MyrG-p-Y424-Src):Irs1 [plasma membrane]'
releaseDate	2018-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9608098] Tsoulfas, Pantelis, 2018-05-09
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus [Species:48898] Bos taurus
stId	R-NUL-9616944
summation	[Summation:9603475] PI3K signaling in mouse cells is stimulated by Ntrk3 (TrkC) ...

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[Deleted:9616948] Deletion of instance: 9603466

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