Reactome | PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane

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PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane Show undefined attributes

catalystActivity	[CatalystActivity:10036036] 1-phosphatidylinositol-4-phosphate 5-kinase activity of PIP5K1A-C [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10036038
displayName	PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane
eventOf	[Pathway:R-MMU-1660499] Synthesis of PIPs at the plasma membrane - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-8849969] PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane - Mus musculus [Reaction:R-MMU-2559456] TIRAP binds PIP2-rich regions in the plasma membrane - Mus musculus [Reaction:R-MMU-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane - Mus musculus [Reaction:R-MMU-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane - Mus musculus [Reaction:R-MMU-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane - Mus musculus [Reaction:R-MMU-2316434] PI3K phosphorylates PIP2 to PIP3 - Mus musculus [Reaction:R-MMU-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane - Mus musculus
inferredFrom	[Reaction:R-HSA-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-392417] PI4P [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
precedingEvent	[Reaction:R-MMU-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane - Mus musculus [Reaction:R-MMU-1676149] PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane - Mus musculus [Reaction:R-MMU-1675780] PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-1676082
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-MMU-8849969] PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane [Reaction:R-MMU-2559456] TIRAP binds PIP2-rich regions in the plasma membrane [Reaction:R-MMU-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane [Reaction:R-MMU-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane [Reaction:R-MMU-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane [Reaction:R-MMU-2316434] PI3K phosphorylates PIP2 to PIP3 [Reaction:R-MMU-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane
(hasEvent)	[Pathway:R-MMU-1660499] Synthesis of PIPs at the plasma membrane [Pathway:R-MMU-6811558] PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
(inferredTo)	[Reaction:R-HSA-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane

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