Reactome | TIRAP binds PIP2-rich regions in the plasma membrane

Schema > Reaction > Entries

TIRAP binds PIP2-rich regions in the plasma membrane Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10691206
displayName	TIRAP binds PIP2-rich regions in the plasma membrane
eventOf	[Pathway:R-XTR-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2559456] TIRAP binds PIP2-rich regions in the plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane] [EntityWithAccessionedSequence:R-XTR-166141] tirap [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	TIRAP binds PIP2-rich regions in the plasma membrane MAL binds PIP2-rich regions in the plasma membrane
output	[Complex:R-XTR-2559415] TIRAP:PI(4,5)P2 [plasma membrane]
precedingEvent	[Reaction:R-XTR-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-2559456
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane
(inferredTo)	[Reaction:R-HSA-2559456] TIRAP binds PIP2-rich regions in the plasma membrane

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