Reactome | PI3K alpha, beta, gamma convert PIP2 to PIP3

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PI3K alpha, beta, gamma convert PIP2 to PIP3 Show undefined attributes

authored	[InstanceEdit:435013] Akkerman, JW, 2009-09-04
catalystActivity	[CatalystActivity:437156] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PI3K alpha, beta, gamma [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:437154] Jupe, S, 2009-09-11
crossReference	[DatabaseIdentifier:12667417] RHEA:21292
dbId	437162
displayName	PI3K alpha, beta, gamma convert PIP2 to PIP3
edited	[InstanceEdit:445674] Jupe, S, 2009-11-03
eventOf	[Pathway:R-HSA-114604] GPVI-mediated activation cascade - Homo sapiens
followingEvent	[Reaction:R-HSA-434633] PIP2 binds inhibiting VAV - Homo sapiens [Reaction:R-HSA-9603279] PIP3 recruits PDK1 and AKT to the membrane - Homo sapiens [Reaction:R-HSA-434637] PI(3,4,5)P3 binds VAV1,2,3 - Homo sapiens [Reaction:R-HSA-2316429] PIP3 recruits PDPK1 to the membrane - Homo sapiens [Reaction:R-HSA-2317332] PIP3 recruits AKT to the membrane - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:425636] Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase [LiteratureReference:437163] Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	PI3K alpha, beta, gamma convert PIP2 to PIP3
orthologousEvent	[Reaction:R-DDI-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Dictyostelium discoideum [Reaction:R-CEL-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Caenorhabditis elegans [Reaction:R-DME-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Drosophila melanogaster [Reaction:R-GGA-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Gallus gallus [Reaction:R-XTR-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Xenopus tropicalis [Reaction:R-DRE-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Danio rerio [Reaction:R-SSC-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Sus scrofa [Reaction:R-BTA-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Bos taurus [Reaction:R-CFA-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Canis familiaris [Reaction:R-RNO-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Rattus norvegicus [Reaction:R-MMU-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-437118] GPVI stimulates PI3K beta, gamma - Homo sapiens [Reaction:R-HSA-114542] RAC1,RAC2,RHOG activate PI3K - Homo sapiens
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:445650] Poole, AW, 2009-11-02 [InstanceEdit:445653] Jones, ML, 2009-11-02 [InstanceEdit:445649] Harper, MT, 2009-11-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-437162
summation	[Summation:437161] Class I Phosphoinositide 3-kinases (PI3Ks) are heterodimeric...

Referrals

(hasEvent)	[Pathway:R-HSA-114604] GPVI-mediated activation cascade
(precedingEvent)	[Reaction:R-HSA-434633] PIP2 binds inhibiting VAV [Reaction:R-HSA-9603279] PIP3 recruits PDK1 and AKT to the membrane [Reaction:R-HSA-434637] PI(3,4,5)P3 binds VAV1,2,3 [Reaction:R-HSA-2316429] PIP3 recruits PDPK1 to the membrane [Reaction:R-HSA-2317332] PIP3 recruits AKT to the membrane

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