Reactome | PDPK1 binds PIP2

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10957552
displayName	PDPK1 binds PIP2
eventOf	[Pathway:R-CEL-1257604] PIP3 activates AKT signaling - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2219524] PDPK1 binds PIP2 - Homo sapiens
input	[EntityWithAccessionedSequence:R-CEL-202210] PDPK1 [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PDPK1 binds PIP2
output	[Complex:R-CEL-2219520] PDPK1:PIP2 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-2219524
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-CEL-1257604] PIP3 activates AKT signaling
(inferredTo)	[Reaction:R-HSA-2219524] PDPK1 binds PIP2