Reactome | G beta:gamma activated PI3Kgamma converts PIP2 to PIP3

Schema > Reaction > Entries

G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 Show undefined attributes

catalystActivity	[CatalystActivity:10505261] phosphatidylinositol-4,5-bisphosphate 3-kinase activity of G-protein beta-gamma:PI3K gamma [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10486564] Wright, Adam, 2024-03-07
dbId	10505263
displayName	G beta:gamma activated PI3Kgamma converts PIP2 to PIP3
eventOf	[Pathway:R-XTR-392451] G beta:gamma signalling through PI3Kgamma - Xenopus tropicalis
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-202692] PIP3 binds to RhoA and activates it - Xenopus tropicalis [Reaction:R-XTR-2316429] PIP3 recruits PDPK1 to the membrane - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	true
name	G beta:gamma activated PI3Kgamma converts PIP2 to PIP3
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-392300
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-392451] G beta:gamma signalling through PI3Kgamma
(precedingEvent)	[Reaction:R-XTR-202692] PIP3 binds to RhoA and activates it [Reaction:R-XTR-2316429] PIP3 recruits PDPK1 to the membrane
(inferredTo)	[Reaction:R-HSA-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3