Reactome | PI3K alpha, beta, gamma convert PIP2 to PIP3

Schema > Reaction > Entries

PI3K alpha, beta, gamma convert PIP2 to PIP3 Show undefined attributes

catalystActivity	[CatalystActivity:10763758] phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PI3K alpha, beta, gamma [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
dbId	10763760
displayName	PI3K alpha, beta, gamma convert PIP2 to PIP3
eventOf	[Pathway:R-CEL-114604] GPVI-mediated activation cascade - Caenorhabditis elegans
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-9603279] PIP3 recruits PDK1 and AKT to the membrane - Caenorhabditis elegans [Reaction:R-CEL-2316429] PIP3 recruits PDPK1 to the membrane - Caenorhabditis elegans [Reaction:R-CEL-2317332] PIP3 recruits AKT to the membrane - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	true
name	PI3K alpha, beta, gamma convert PIP2 to PIP3
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent	[Reaction:R-CEL-114542] RAC1,RAC2,RHOG activate PI3K - Caenorhabditis elegans
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-437162
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-114604] GPVI-mediated activation cascade
(precedingEvent)	[Reaction:R-CEL-9603279] PIP3 recruits PDK1 and AKT to the membrane [Reaction:R-CEL-2316429] PIP3 recruits PDPK1 to the membrane [Reaction:R-CEL-2317332] PIP3 recruits AKT to the membrane
(inferredTo)	[Reaction:R-HSA-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3