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Schema
>
Reaction
>
Entries
PI3K synthesizes PIP3 downstream of ALK mutants
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authored
[InstanceEdit:9724129] Rothfels, Karen, 2021-03-22
catalystActivity
[CatalystActivity:9711930] phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PI3K-binding ALK fusions:PI3K [cytosol]
category
transition
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:9712080] Rothfels, Karen, 2021-01-14
crossReference
[DatabaseIdentifier:11880467] Rhea:21292
dbId
9712084
disease
[Disease:1500689] cancer
displayName
PI3K synthesizes PIP3 downstream of ALK mutants
edited
[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
eventOf
[Pathway:R-HSA-9725370] Signaling by ALK fusions and activated point mutants - Homo sapiens
input
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9699737] Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathway
[LiteratureReference:201541] Role of phosphatidylinositol 3-kinase-Akt pathway in nucleophosmin/anaplastic lymphoma kinase-mediated lymphomagenesis
[LiteratureReference:9699732] NPM/ALK downregulates p27Kip1 in a PI-3K-dependent manner
[LiteratureReference:9699730] NPM-ALK fusion kinase of anaplastic large-cell lymphoma regulates survival and proliferative signaling through modulation of FOXO3a
[LiteratureReference:9700372] Oncogenic mutations of ALK kinase in neuroblastoma
[LiteratureReference:9699725] Inhibition of Akt increases p27Kip1 levels and induces cell cycle arrest in anaplastic large cell lymphoma
[LiteratureReference:9699745] Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway
[LiteratureReference:9667881] The anaplastic lymphoma kinase in the pathogenesis of cancer
[LiteratureReference:9667872] Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology
modified
[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name
PI3K synthesizes PIP3 downstream of ALK mutants
normalReaction
[Reaction:R-HSA-201510] PI3K synthesizes PIP3 downstream of ALK
output
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent
[Reaction:R-HSA-9712083] ALK mutants bind PI3KCA - Homo sapiens
releaseDate
2021-06-09
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9712084
summation
[Summation:9711767] PI3K phosphorylates PIP2 to PIP3 downstream of activated ALK...
Referrals
(hasEvent)
[Pathway:R-HSA-9725370] Signaling by ALK fusions and activated point mutants
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