Reactome | BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3.

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BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3. Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
catalystActivity	[CatalystActivity:1839104] phosphatidylinositol-4,5-bisphosphate 3-kinase activity of pY177-BCR-pY-FGFR1 mutant:GRB2:p-GAB1:PI3K [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:1839108] Rothfels, K, 2011-10-27
crossReference	[DatabaseIdentifier:11880431] Rhea:21292
dbId	1839107
disease	[Disease:1500689] cancer [Disease:1247687] chronic myeloid leukemia
displayName	BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3.
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5654474] gain_of_function of pY177-BCR-pY-FGFR1 mutant:GRB2:p-GAB1:PI3K [cytosol]
eventOf	[Pathway:R-HSA-1839117] Signaling by cytosolic FGFR1 fusion mutants - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1604429] Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations [LiteratureReference:1604434] The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3.
normalReaction	[Reaction:R-HSA-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-1839102] BCR-FGFR1 fusion:GRB2:p-GAB2:PIK3R1 binds PIK3CA - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1839107
summation	[Summation:2085563] Once recruited to the activated BCR-FGFR1 fusion PI3K phosph...

Referrals

(hasEvent)

[Pathway:R-HSA-1839117] Signaling by cytosolic FGFR1 fusion mutants

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