Reactome | PI3K-containing complexes phosphorylate PIP2 to PIP3

Schema > Reaction > Entries

PI3K-containing complexes phosphorylate PIP2 to PIP3 Show undefined attributes

catalystActivity	[CatalystActivity:10210962] 1-phosphatidylinositol-3-kinase activity of PI3K-containing complexes [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:74700] endosome membrane
created	[InstanceEdit:10203599] Wright, Adam, 2024-03-07
dbId	10210964
displayName	PI3K-containing complexes phosphorylate PIP2 to PIP3
eventOf	[Pathway:R-BTA-109704] PI3K Cascade - Bos taurus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-109700] AKT2 binds PIP3 - Bos taurus [Reaction:R-BTA-109701] PDPK1 binds PIP3 - Bos taurus
inferredFrom	[Reaction:R-HSA-109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	true
name	PI3K-containing complexes phosphorylate PIP2 to PIP3
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent	[Reaction:R-BTA-188002] Rab5-mediated recruitment of class III PI3K to TLR9 - Bos taurus [Reaction:R-BTA-74737] p-Y-IRS1,p-Y-IRS2 bind PI3K - Bos taurus
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-109699
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-109704] PI3K Cascade
(precedingEvent)	[Reaction:R-BTA-109700] AKT2 binds PIP3 [Reaction:R-BTA-109701] PDPK1 binds PIP3
(inferredTo)	[Reaction:R-HSA-109699] PI3K-containing complexes phosphorylate PIP2 to PIP3