Reactome | Activated NTRK3 stimulates PI3K activity

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Activated NTRK3 stimulates PI3K activity Show undefined attributes

authored	[InstanceEdit:9034018] Orlic-Milacic, Marija, 2018-01-02
catalystActivity	[CatalystActivity:9603444] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane]
category	uncertain
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9603442] Orlic-Milacic, Marija, 2018-03-21
crossReference	[DatabaseIdentifier:12667417] RHEA:21292
dbId	9603445
displayName	Activated NTRK3 stimulates PI3K activity
edited	[InstanceEdit:9608101] Orlic-Milacic, Marija, 2018-05-09
eventOf	[Pathway:R-HSA-9603381] Activated NTRK3 signals through PI3K - Homo sapiens
inferredFrom	[BlackBoxEvent:R-NUL-9616944] Activated Ntrk3 stimulates PI3K activity - Mus musculus
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated NTRK3 stimulates PI3K activity
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9603420] Activated NTRK3 promotes SRC autophosphorylation - Homo sapiens [Reaction:R-HSA-9603437] Activated NTRK3 binds IRS1 - Homo sapiens [Reaction:R-HSA-9603407] Activated NTRK3 binds PI3K - Homo sapiens
regulatedBy	[PositiveRegulation:9603443] Positive regulation by 'NTF3:p-5Y-NTRK3 homodimer:MyrG-p-Y419-SRC,(NTF3:p-5Y-NTRK3 homodimer,NTF3:p-5Y-NTRK3 homodimer:MyrG-p-Y419-SRC) [plasma membrane]'
releaseDate	2018-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9608098] Tsoulfas, Pantelis, 2018-05-09
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9603445
summation	[Summation:9603474] Activation of PI3K signaling downstream of NTRK3 (TRKC) is e...

Referrals

(hasEvent)	[Pathway:R-HSA-9603381] Activated NTRK3 signals through PI3K
(inferredTo)	[BlackBoxEvent:R-NUL-9616944] Activated Ntrk3 stimulates PI3K activity

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