Reactome | Activation of WASP and N-WASP by CDC42

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Activation of WASP and N-WASP by CDC42 Show undefined attributes

authored	[InstanceEdit:2029483] Garapati, P V, 2012-01-04
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:442541] Jupe, S, 2009-09-28
dbId	442572
displayName	Activation of WASP and N-WASP by CDC42
edited	[InstanceEdit:2029483] Garapati, P V, 2012-01-04 [InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
input	[Complex:R-MMU-448879] Cdc42:GTP [plasma membrane] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane] [DefinedSet:R-MMU-2029096] Wasp/N-Wasp [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2028921] Cdc42 regulates Fc gamma receptor-mediated phagocytosis through the activation and phosphorylation of Wiskott-Aldrich syndrome protein (WASP) and neural-WASP [LiteratureReference:442552] The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly [LiteratureReference:442550] Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42 [LiteratureReference:442590] Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activation of WASP and N-WASP by CDC42
orthologousEvent	[Reaction:R-HSA-9670155] CDC42:GTP binds PtdIns(4,5)P2:WASP,N-WASP - Homo sapiens [Reaction:R-HSA-442586] Activation of WASP and N-WASP by CDC42 - Homo sapiens
output	[Complex:R-MMU-2029162] Cdc42-GTP:Wasp/N-Wasp [cytosol]
releaseDate	2013-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248842] Rosales, C, 2012-05-14 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-442572
summation	[Summation:5672395] The activation of WASP and N-WASP (WASL) by CDC42:GTP was de...
updateTrackers	[UpdateTracker:9784993] Update Tracker - [Reaction:442572] Activation of WASP and N-WASP by CDC42 - v52:[add_removeSummation]

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[UpdateTracker:9784993] Update Tracker - [Reaction:442572] Activation of WASP and N-WASP by CDC42 - v52:[add_removeSummation]