Reactome | Activation of WASP and N-WASP by CDC42

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Activation of WASP and N-WASP by CDC42 Show undefined attributes

authored	[InstanceEdit:434636] Jupe, S, 2009-09-02
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:442541] Jupe, S, 2009-09-28
dbId	442586
displayName	Activation of WASP and N-WASP by CDC42
edited	[InstanceEdit:2029483] Garapati, P V, 2012-01-04 [InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
eventOf	[Pathway:R-HSA-5663213] RHO GTPases Activate WASPs and WAVEs - Homo sapiens [Pathway:R-HSA-2029482] Regulation of actin dynamics for phagocytic cup formation - Homo sapiens [Pathway:R-HSA-9664422] FCGR3A-mediated phagocytosis - Homo sapiens
followingEvent	[Reaction:R-HSA-2197691] WIP binds WASP,N-WASP, activating them - Homo sapiens
inferredFrom	[Reaction:R-MMU-442572] Activation of WASP and N-WASP by CDC42 - Mus musculus
input	[Complex:R-HSA-182921] CDC42:GTP [plasma membrane] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane] [DefinedSet:R-HSA-201892] WASP/N-WASP [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:442552] The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly [LiteratureReference:2028916] EVH1/WH1 domains of VASP and WASP proteins belong to a large family including Ran-binding domains of the RanBP1 family [LiteratureReference:372997] Regulation of WASP/WAVE proteins: making a long story short [LiteratureReference:2028918] Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein [LiteratureReference:2028921] Cdc42 regulates Fc gamma receptor-mediated phagocytosis through the activation and phosphorylation of Wiskott-Aldrich syndrome protein (WASP) and neural-WASP [LiteratureReference:2028917] Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activation of WASP and N-WASP by CDC42
orthologousEvent	[Reaction:R-HSA-9670156] PtdIns(4,5)P2 binds WASP, N-WASP - Homo sapiens
output	[Complex:R-HSA-442584] CDC42:GTP:WASP/N-WASP [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-2029445] An unknown GEF exchanges GTP for GDP on CDC42:GDP - Homo sapiens
releaseDate	2013-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248842] Rosales, C, 2012-05-14 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-442586
summation	[Summation:442581] Wiskott-Aldrich syndrome protein (WASP) and Neural-WASP (N-W...

Referrals

(hasEvent)	[Pathway:R-HSA-9664422] FCGR3A-mediated phagocytosis [Pathway:R-HSA-5663213] RHO GTPases Activate WASPs and WAVEs [Pathway:R-HSA-2029482] Regulation of actin dynamics for phagocytic cup formation
(precedingEvent)	[Reaction:R-HSA-2197691] WIP binds WASP,N-WASP, activating them
(inferredTo)	[Reaction:R-MMU-442572] Activation of WASP and N-WASP by CDC42