Reactome | NTRK2-activated PI3K generates PIP3

Schema > BlackBoxEvent > Entries

authored	[InstanceEdit:9034391] Orlic-Milacic, Marija, 2018-01-05
catalystActivity	[CatalystActivity:9028757] 1-phosphatidylinositol-3-kinase activity of BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane]
category	uncertain
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9028521] Orlic-Milacic, Marija, 2017-11-09
dbId	9028519
displayName	NTRK2-activated PI3K generates PIP3
edited	[InstanceEdit:9037703] Orlic-Milacic, Marija, 2018-02-20
eventOf	[Pathway:R-HSA-9028335] Activated NTRK2 signals through PI3K - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-9031553] Activated Ntrk2 activates PI3K signaling - Mus musculus
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NTRK2-activated PI3K generates PIP3
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9028505] Activated NTRK2 recruits PI3K - Homo sapiens
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9037707] Antila, Hanna, 2018-02-13 [InstanceEdit:9037710] Castr�n, Eero, 2018-02-13
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9028519
summation	[Summation:9031555] Based on studies in mice, activated NTRK2 induces activation...

(hasEvent)	[Pathway:R-HSA-9028335] Activated NTRK2 signals through PI3K
(inferredTo)	[BlackBoxEvent:R-MMU-9031553] Activated Ntrk2 activates PI3K signaling

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