Reactome | Synthesis of PIP3 from PIP2 by PI3K

Schema > Reaction > Entries

Synthesis of PIP3 from PIP2 by PI3K Show undefined attributes

catalystActivity	[CatalystActivity:10515091] 1-phosphatidylinositol-3-kinase activity of PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10486564] Wright, Adam, 2024-03-07
dbId	10515093
displayName	Synthesis of PIP3 from PIP2 by PI3K
eventOf	[Pathway:R-XTR-1433557] Signaling by SCF-KIT - Xenopus tropicalis
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-1433542] Phosphorylation and activation of VAV1 - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-1433514] Synthesis of PIP3 from PIP2 by PI3K - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	true
name	Synthesis of PIP3 from PIP2 by PI3K
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent	[Reaction:R-XTR-205262] Direct recruitment of PI3K to p-KIT - Xenopus tropicalis [Reaction:R-XTR-1562641] Indirect recruitment of PI3K to KIT via p(Y)-GAB2 - Xenopus tropicalis
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-1433514
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-1433557] Signaling by SCF-KIT
(precedingEvent)	[Reaction:R-XTR-1433542] Phosphorylation and activation of VAV1
(inferredTo)	[Reaction:R-HSA-1433514] Synthesis of PIP3 from PIP2 by PI3K