Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
p-S123-CDC25A [nucleoplasm]
Stable Identifier
R-HSA-143488
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
phospho-Cdc25A
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G1/S DNA Damage Checkpoints (Homo sapiens)
p53-Independent G1/S DNA damage checkpoint (Homo sapiens)
p53-Independent DNA Damage Response (Homo sapiens)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Homo sapiens)
Phosphorylation of Cdc25A at Ser-123 by Chk1 (Homo sapiens)
p-S123-CDC25A [nucleoplasm] (Homo sapiens)
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Homo sapiens)
p-S123-CDC25A [nucleoplasm] (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
Activation of ATR in response to replication stress (Homo sapiens)
Phosphorylation of Cdc25A at Ser-123 by Chk1 (Homo sapiens)
p-S123-CDC25A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P30304 CDC25A
Gene Names
CDC25A
Chain
chain:1-524
Reference Genes
BioGPS Gene:993 CDC25A
COSMIC (genes):CDC25A CDC25A
CTD Gene:993 CDC25A
dbSNP Gene:993 CDC25A
ENSEMBL:ENSG00000164045 CDC25A
HGNC:1725 CDC25A
KEGG Gene (Homo sapiens):993 CDC25A
Monarch:993 CDC25A
NCBI Gene:993 CDC25A
OMIM:116947 CDC25A
UCSC:P30304 CDC25A
Reference Transcript
RefSeq:NM_201567.1 CDC25A
RefSeq:NM_001789.2 CDC25A
RefSeq:XM_011534316.1 CDC25A
Other Identifiers
0001690075
11726756_a_at
11726757_s_at
11726758_a_at
1555772_a_at
16953279
1738_at
204695_at
204696_s_at
2673086
2673087
2673088
2673089
2673091
2673092
2673093
2673094
2673096
2673097
2673098
2673100
2673102
2673104
2673105
2673106
2673107
2673108
35407_at
54538_at
8086880
993
A_23_P121423
A_24_P397107
GE58099
GO:0000003
GO:0000079
GO:0000082
GO:0000086
GO:0000278
GO:0003674
GO:0004721
GO:0004725
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006464
GO:0006470
GO:0007049
GO:0008150
GO:0008283
GO:0009314
GO:0010971
GO:0016579
GO:0016787
GO:0016791
GO:0019899
GO:0019901
GO:0034644
GO:0035335
GO:0043226
GO:0045931
GO:0051087
GO:0051301
GO:0051726
GO:0110032
GO:1902751
Hs.1634.0.S2_3p_at
Hs2.1634.2.S1_3p_s_at
ILMN_1711005
ILMN_1733396
M81933_at
PH_hs_0000223
TC03001374.hg
g4502704_3p_a_at
Participant Of
output
Phosphorylation of Cdc25A at Ser-123 by Chk1
Phosphorylation of Cdc25A at Ser-123 by Chk2
Other forms of this molecule
CDC25A [nucleoplasm]
CDC25A [cytosol]
p-S123-CDC25A [cytosol]
p-S40,S116,S261-CDC25A [nucleoplasm]
PolyUb-CDC25A [cytosol]
Inferred To
phospho-cdc-25.2 [nucleoplasm] (Caenorhabditis elegans)
phospho-cdc25 [nucleoplasm] (Dictyostelium discoideum)
phospho-cdc25 [nucleoplasm] (Schizosaccharomyces pombe)
phospho-cdc25b [nucleoplasm] (Danio rerio)
phospho-cdc-25.3 [nucleoplasm] (Caenorhabditis elegans)
phospho-cdc25a [nucleoplasm] (Xenopus tropicalis)
phospho-stg [nucleoplasm] (Drosophila melanogaster)
phospho-cdc-25.1 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-S123-CDC25A [nucleoplasm] (Gallus gallus)
phospho-Cdc25a [nucleoplasm] (Mus musculus)
phospho-Cdc25a [nucleoplasm] (Rattus norvegicus)
phospho-cdc-25.4 [nucleoplasm] (Caenorhabditis elegans)
phospho-MIH1 [nucleoplasm] (Saccharomyces cerevisiae)
Homologues of p-S123-CDC25A [nucleoplasm] (Caenorhabditis elegans)
Homologues of p-S123-CDC25A [nucleoplasm] (Danio rerio)
Homologues of p-S123-CDC25A [nucleoplasm] (Drosophila melanogaster)
phospho-twe [nucleoplasm] (Drosophila melanogaster)
phospho-cdc25d [nucleoplasm] (Danio rerio)
phospho-CDC25A [nucleoplasm] (Canis familiaris)
phospho-CDC25A [nucleoplasm] (Sus scrofa)
Modified Residues
Name
O-phospho-L-serine at 123
Coordinate
123
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_011532618.1
,
NP_963861.1
,
NP_001780.2
ZINC - World Drugs
MPIP1_HUMAN
OpenTargets
ENSG00000164045
ZINC - FDA approved
MPIP1_HUMAN
ZINC - Substances
MPIP1_HUMAN
ZINC target
P30304
ZINC - Biogenic
MPIP1_HUMAN
PRO
P30304
PDB
1C25
ZINC - Metabolites
MPIP1_HUMAN
GeneCards
P30304
HPA
ENSG00000164045-CDC25A
Ensembl
ENST00000302506
,
ENSP00000303706
,
ENST00000351231
,
ENSP00000343166
,
ENSG00000164045
ZINC - Predictions - Purchasable
MPIP1_HUMAN
HMDB Protein
HMDBP08919
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UKB1 FBXW11
1
FBXW11 [cytosol]
(R-HSA-976035)
0.708
4
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.706
10
UniProt:Q9Y297 BTRC
2
BTRC [nucleoplasm]
(R-HSA-3361753)
BTRC [cytosol]
(R-HSA-174237)
0.691
4
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.69
5
UniProt:O96017 CHEK2
3
p-T68-CHEK2 [nucleoplasm]
(R-HSA-113825)
p-S,3T-CHEK2 [nucleoplasm]
(R-HSA-5683784)
CHEK2 [nucleoplasm]
(R-HSA-113824)
0.623
2
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.597
3
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.597
3
UniProt:Q9BSU3 NAA11
0.556
3
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.544
2
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.462
2
UniProt:P30101 PDIA3
3
PDIA3 [recycling endosome membrane]
(R-HSA-8863849)
PDIA3 [phagocytic vesicle]
(R-HSA-1236870)
PDIA3 [endoplasmic reticulum lumen]
(R-HSA-901028)
0.462
2
UniProt:P63208 SKP1
2
SKP1 [cytosol]
(R-HSA-174150)
SKP1 [nucleoplasm]
(R-HSA-187538)
0.462
2
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text