Reactome | p-Y-IRS1 [plasma membrane]

p-Y-IRS1 [plasma membrane]

Stable Identifier

R-HSA-198366

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Phospho-IRS1 (by TRKA), IRS-1

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - PI3K/AKT Signaling in Cancer (Homo sapiens)
    - Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
      - PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
        
        PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Homo sapiens)
        
        Phospho-IRS1/2 (by TRKA) [plasma membrane] (Homo sapiens)
        
        p-Y-IRS1 [plasma membrane] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Homo sapiens)
        
        Phospho-IRS1/2 (by TRKA) [plasma membrane] (Homo sapiens)
        
        p-Y-IRS1 [plasma membrane] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - Negative regulation of the PI3K/AKT network (Homo sapiens)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
        
        PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Homo sapiens)
        
        Phospho-IRS1/2 (by TRKA) [plasma membrane] (Homo sapiens)
        
        p-Y-IRS1 [plasma membrane] (Homo sapiens)
    - PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
      - Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Homo sapiens)
        
        Phospho-IRS1/2 (by TRKA) [plasma membrane] (Homo sapiens)
        
        p-Y-IRS1 [plasma membrane] (Homo sapiens)
- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - PI3K/AKT activation (Homo sapiens)
        
        PI3K produces PIP3 and other phosphatidyl inositides (Homo sapiens)
        
        Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Homo sapiens)
        
        Phospho-IRS1/2 (by TRKA) [plasma membrane] (Homo sapiens)
        
        p-Y-IRS1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P35568 IRS1

Gene Names

IRS1

Chain

chain:1-1242

Reference Genes

BioGPS Gene:3667 IRS1

COSMIC (genes):IRS1 IRS1

CTD Gene:3667 IRS1

dbSNP Gene:3667 IRS1

ENSEMBL:ENSG00000169047 IRS1

ENSEMBL:ENSG00000169047.6 IRS1

HGNC:6125 IRS1

KEGG Gene (Homo sapiens):3667 IRS1

Monarch:3667 IRS1

NCBI Gene:3667 IRS1

UCSC:P35568 IRS1

Reference Transcript

RefSeq:NM_005544.2 IRS1

Other Identifiers

11743627_a_at

11743628_at

11743629_at

16909165

204686_PM_at

204686_at

242979_PM_at

242979_at

2602018

2602019

2602020

2602036

2602037

2602038

2602039

2602040

2602041

2602042

2602043

2602044

2602045

2602046

2602047

2602048

2602049

2602050

2602051

2602073

2602074

2602075

2602085

2602087

3667

41049_at

75148_at

8059470

850_r_at

851_s_at

872_i_at

A_24_P225679

A_24_P802145

GE58787

GO:0001784

GO:0005068

GO:0005080

GO:0005158

GO:0005159

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0005899

GO:0005901

GO:0005975

GO:0006091

GO:0006629

GO:0007165

GO:0008284

GO:0008286

GO:0010907

GO:0014065

GO:0023052

GO:0030159

GO:0032000

GO:0032868

GO:0032869

GO:0042169

GO:0042593

GO:0043226

GO:0043231

GO:0043434

GO:0043548

GO:0043552

GO:0045725

GO:0046326

GO:0046627

GO:0046628

GO:0046676

GO:0048009

GO:0055085

GO:0060090

GO:0071398

HMNXSV003036377

Hs.257786.0.A1_3p_at

ILMN_1759232

PH_hs_0024522

S62539_at

TC02002830.hg

TC02004835.hg

g5031804_3p_at

Participates

as a member of

Phospho-IRS1/2 (by TRKA) [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-Y-IRS1 [cytosol]

IRS1 [cytosol]

IRS1 [plasma membrane]

p-6Y-IRS1 [plasma membrane]

Inferred To

phospho-chico [plasma membrane] (Drosophila melanogaster)

phospho-p-Y-IRS1 [plasma membrane] (Danio rerio)

phospho-p-Y-IRS1 [plasma membrane] (Gallus gallus)

phospho-Irs1 [plasma membrane] (Mus musculus)

phospho-Irs1 [plasma membrane] (Rattus norvegicus)

phospho-IRS1 [plasma membrane] (Bos taurus)

phospho-IRS1 [plasma membrane] (Sus scrofa)

phospho-irs1 [plasma membrane] (Xenopus tropicalis)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_005535.1

OpenTargets

ENSG00000169047

GeneCards

P35568

HPA

ENSG00000169047-IRS1

Ensembl

ENSG00000169047, ENSP00000304895, ENST00000305123

PRO

P35568

Pharos - Targets

P35568

PDB

5U1M, 7PPL, 7PPM, 6BNT, 2Z8C, 1IRS, 1K3A, 1QQG

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.921	13
UniProt:P42336 PIK3CA	20	PIK3CA H1047L [cytosol] (R-HSA-1500714) PIK3CA H1047R [cytosol] (R-HSA-1500716) PIK3CA M1043I [cytosol] (R-HSA-1500719) PIK3CA M1043T [cytosol] (R-HSA-2395934) PIK3CA M1043V [cytosol] (R-HSA-2395932) PIK3CA H1047Y [cytosol] (R-HSA-1500720) PIK3CA E542K [cytosol] (R-HSA-1500701) PIK3CA Q546K [cytosol] (R-HSA-1500705) PIK3CA E545A [cytosol] (R-HSA-2362355) PIK3CA E545K [cytosol] (R-HSA-1500706) PIK3CA E545Q [cytosol] (R-HSA-2362362) PIK3CA Q546E [cytosol] (R-HSA-2362383) PIK3CA E545V [cytosol] (R-HSA-2362365) PIK3CA E542V [cytosol] (R-HSA-2328074) PIK3CA Q546L [cytosol] (R-HSA-2362375) PIK3CA E545G [cytosol] (R-HSA-1500709) PIK3CA Q546H [cytosol] (R-HSA-2362374) PIK3CA Q546R [cytosol] (R-HSA-2362373) PIK3CA Q546P [cytosol] (R-HSA-1500695) PIK3CA E542Q [cytosol] (R-HSA-2328003)	0.81	22
UniProt:P06213 INSR	6	p-6Y-INSR(763-1382) [endosome membrane] (R-HSA-141719) INSR(763-1382) [endosome membrane] (R-HSA-141722) INSR(28-758) [endosome membrane] (R-HSA-141718) INSR(763-1382) [plasma membrane] (R-HSA-74669) p-6Y-INSR(763-1382) [plasma membrane] (R-HSA-74670) INSR(28-758) [plasma membrane] (R-HSA-74668)	0.704	5
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.682	6
UniProt:P27986-2 PIK3R1			0.57	3
UniProt:O75815 BCAR3			0.57	3
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.57	4
UniProt:P03495 NS1			0.508	2
UniProt:P09217 Prkcz	7	Protein kinase C, zeta type, phosphorylated [cytosol] (R-RNO-437269) Protein kinase C, zeta type [cytosol] (R-RNO-113489) phospho-pS, p-T410-PRKCZ [cytosol] (R-RNO-9632824) phospho-p-T410,T563-PRKCZ [cytosol] (R-RNO-5218698) phospho-p-T410-PRKCZ [cytosol] (R-RNO-437181) PRKCZ [cytosol] (R-RNO-58218) PRKCZ [cell junction] (R-RNO-2134483)	0.502	2
UniProt:P11940 PABPC1	1	PABPC1 [cytosol] (R-HSA-156803)	0.499	2
UniProt:P49757 NUMB	1	NUMB [plasma membrane] (R-HSA-443595)	0.488	2

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