Reactome | monoSUMO1-K559-HDAC4 [nucleoplasm]

monoSUMO1-K559-HDAC4 [nucleoplasm]

Stable Identifier

R-HSA-4616016

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone deacetylase 4, HDAC4_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P56524 HDAC4

Gene Names

HDAC4, KIAA0288

Chain

chain:1-1084

Reference Genes

COSMIC (genes):HDAC4 HDAC4

dbSNP Gene:9759 HDAC4

ENSEMBL:ENSG00000068024 HDAC4

Participates

as an output of

RANBP2 SUMOylates HDAC4 with SUMO1 (Homo sapiens)

Other forms of this molecule

polySUMO2,3-K559-HDAC4 [nucleoplasm]

HDAC4 [nucleoplasm]

Inferred To

hda-4 [nucleoplasm] (Caenorhabditis elegans)

hdaD [nucleoplasm] (Dictyostelium discoideum)

Homologues of monoSUMO1-K559-HDAC4 [nucleoplasm] (Dictyostelium discoideum)

Homologues of monoSUMO1-K559-HDAC4 [nucleoplasm] (Plasmodium falciparum)

clr3 [nucleoplasm] (Schizosaccharomyces pombe)

HDA1 [nucleoplasm] (Saccharomyces cerevisiae)

monoSUMO1-K559-HDAC4 [nucleoplasm] (Bos taurus)

monoSUMO1-K559-HDAC4 [nucleoplasm] (Dictyostelium discoideum)

monoSUMO1-K559-HDAC4 [nucleoplasm] (Gallus gallus)

monoSUMO1-K559-HDAC4 [nucleoplasm] (Mus musculus)

monoSUMO1-K559-HDAC4 [nucleoplasm] (Plasmodium falciparum)

monoSUMO1-K559-HDAC4 [nucleoplasm] (Rattus norvegicus)

monoSUMO1-K559-HDAC4 [nucleoplasm] (Sus scrofa)

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 559

Coordinate

559

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Interactors (32)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.947	15
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.899	9
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.886	10
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.865	9
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.783	8
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.774	6
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.774	6
UniProt:P56524 HDAC4	3	polySUMO2,3-K559-HDAC4 [nucleoplasm] (R-HSA-4616029) monoSUMO1-K559-HDAC4 [nucleoplasm] (R-HSA-4616016) HDAC4 [nucleoplasm] (R-HSA-351581)	0.655	4
UniProt:Q8AZK7 EBNA5			0.612	5
UniProt:A9UHW6 MI4GD			0.602	4
UniProt:Q13761 RUNX3	7	PolyUb-RUNX3 [nucleoplasm] (R-HSA-8952417) p-Y-RUNX3 [cytosol] (R-HSA-8937805) PolyUb-K94,K148-RUNX3 [nucleoplasm] (R-HSA-8952387) PolyUb-K94,K148-RUNX3 [cytosol] (R-HSA-8952400) Ac-K94,K171-RUNX3 [nucleoplasm] (R-HSA-8951965) RUNX3 [cytosol] (R-HSA-8937797) RUNX3 [nucleoplasm] (R-HSA-8865393)	0.558	9
UniProt:Q01850 CDR2			0.556	3
UniProt:O95967 EFEMP2	1	EFEMP2 [extracellular region] (R-HSA-2161231)	0.556	3
UniProt:Q9H9E1 ANRA2			0.556	3
UniProt:Q8ND90 PNMA1			0.556	3
UniProt:Q6NUQ1 RINT1	1	RINT1 [cytosol] (R-HSA-6810991)	0.556	3
UniProt:Q96JN2-2 CCDC136			0.556	3
UniProt:O95751 LDOC1			0.556	3
UniProt:Q5JR59 MTUS2			0.556	3
UniProt:O76015 KRT38	1	KRT38 [cytosol] (R-HSA-6809615)	0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:P10275 AR	4	AR [cytosol] (R-HSA-5618082) AR [nucleoplasm] (R-HSA-446174) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984)	0.544	4
UniProt:O75376 NCOR1	2	NCOR1 [cytosol] (R-HSA-1253310) NCOR1 [nucleoplasm] (R-HSA-442501)	0.527	2
UniProt:O15379 HDAC3	2	HDAC3 [nucleoplasm] (R-HSA-442464) Unfolded HDAC3 [cytosol] (R-HSA-6813777)	0.527	2
UniProt:Q9HCU9 BRMS1	1	BRMS1 [nucleoplasm] (R-HSA-4650034)	0.524	2
UniProt:P08393 ICP0			0.524	3
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [nucleoplasm] (R-HSA-912481) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) UBE2I [cytosol] (R-HSA-4655342)	0.508	3
UniProt:P41182 BCL6	1	BCL6 [nucleoplasm] (R-HSA-5223066)	0.499	3
UniProt:Q06413 MEF2C	3	MEF2C [nucleoplasm] (R-HSA-199938) p-S396-MEF2C [nucleoplasm] (R-HSA-199942) p-T293,T300,S387-MEF2C [nucleoplasm] (R-HSA-448838)	0.491	2
UniProt:Q02078 MEF2A	3	p-T312,T319-MEF2A [nucleoplasm] (R-HSA-448834) p-S408-MEF2A [nucleoplasm] (R-HSA-199909) MEF2A [nucleoplasm] (R-HSA-199903)	0.489	2

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