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TIAM1 [cytosol]
Stable Identifier
R-HSA-195013
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Tiam1
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPH-ephrin mediated repulsion of cells (Homo sapiens)
EPHA binds TIAM1 (Homo sapiens)
EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Homo sapiens)
TIAM1 [cytosol] (Homo sapiens)
TIAM1 [cytosol] (Homo sapiens)
TIAM1 exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Homo sapiens)
TIAM1 [cytosol] (Homo sapiens)
EPHB-mediated forward signaling (Homo sapiens)
EPHB phosphorylates TIAM1 (Homo sapiens)
EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Homo sapiens)
TIAM1 [cytosol] (Homo sapiens)
EPHB:NMDAR binds TIAM1 (Homo sapiens)
EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Homo sapiens)
TIAM1 [cytosol] (Homo sapiens)
TIAM1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
TIAM1 [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
GEFs activate RhoA,B,C (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
TIAM1 [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK2 (TRKB) (Homo sapiens)
Activated NTRK2 signals through CDK5 (Homo sapiens)
NTRK2 binds TIAM1 (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 homodimer:TIAM1 [plasma membrane] (Homo sapiens)
TIAM1 [cytosol] (Homo sapiens)
TIAM1 [cytosol] (Homo sapiens)
NTRK2 promotes TIAM1 phosphorylation (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 homodimer:TIAM1 [plasma membrane] (Homo sapiens)
TIAM1 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 GEFs activate CDC42 (Homo sapiens)
CDC42 GEFs [cytosol] (Homo sapiens)
TIAM1 [cytosol] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GEFs activate RAC1 (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
TIAM1 [cytosol] (Homo sapiens)
RAC2 GTPase cycle (Homo sapiens)
RAC2 GEFs activate RAC2 (Homo sapiens)
RAC2 GEFs [cytosol] (Homo sapiens)
TIAM1 [cytosol] (Homo sapiens)
RAC3 GTPase cycle (Homo sapiens)
RAC3 GEFs activate RAC3 (Homo sapiens)
RAC3 GEFs [cytosol] (Homo sapiens)
TIAM1 [cytosol] (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA GEFs activate RHOA (Homo sapiens)
RHOA GEFs [cytosol] (Homo sapiens)
TIAM1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13009 TIAM1
Gene Names
TIAM1
Chain
initiator methionine:1, chain:2-1591
Reference Genes
BioGPS Gene:7074 TIAM1
COSMIC (genes):TIAM1 TIAM1
CTD Gene:7074 TIAM1
dbSNP Gene:7074 TIAM1
ENSEMBL:ENSG00000156299.15 TIAM1
HGNC:11805 TIAM1
KEGG Gene (Homo sapiens):7074 TIAM1
Monarch:7074 TIAM1
NCBI Gene:7074 TIAM1
OMIM:600687 TIAM1
UCSC:Q13009 TIAM1
Reference Transcript
RefSeq:XM_017028453.1 TIAM1
RefSeq:NM_003253.2 TIAM1
RefSeq:XM_017028447.1 TIAM1
RefSeq:XM_017028452.1 TIAM1
RefSeq:XM_011529713.1 TIAM1
RefSeq:XM_017028451.1 TIAM1
RefSeq:XM_011529711.1 TIAM1
RefSeq:XM_011529712.1 TIAM1
RefSeq:XM_017028450.1 TIAM1
RefSeq:XM_005261038.2 TIAM1
RefSeq:XM_017028449.1 TIAM1
RefSeq:XM_005261037.1 TIAM1
RefSeq:XM_017028448.1 TIAM1
Other Identifiers
11732415_s_at
11732416_a_at
16924878
206409_PM_at
206409_at
213135_PM_at
213135_at
37460_at
38370_at
3928667
3928670
3928671
3928672
3928673
3928674
3928675
3928678
3928679
3928681
3928682
3928683
3928685
3928686
3928687
3928691
3928692
3928693
3928698
3928702
3928703
3928705
3928708
3928709
3928710
3928713
3928715
3928717
3928718
3928719
3928721
3928722
3928723
3928730
3928734
3928735
3928748
3928759
3928783
7074
8069880
A_23_P17624
A_33_P3381751
GE58965
GE59547
GO:0005085
GO:0005515
GO:0005829
GO:0005886
GO:0005911
GO:0007155
GO:0007160
GO:0007165
GO:0007264
GO:0008284
GO:0008289
GO:0010717
GO:0010718
GO:0016020
GO:0016477
GO:0016601
GO:0019900
GO:0023052
GO:0030154
GO:0030335
GO:0030695
GO:0031234
GO:0032092
GO:0035556
GO:0044291
GO:0045202
GO:0048013
GO:0048856
GO:0048870
GO:0050772
GO:0051056
GO:0060071
GO:0065003
GO:0070161
GO:0090630
GO:0098772
GO:1904338
GO:2000050
HMNXSV003047589
HMNXSV003054829
Hs.82141.0.S1_3p_at
ILMN_1655577
PH_hs_0006311
TC21000388.hg
U16296_at
U90902_at
g4507500_3p_at
Participates
as a candidate of
RHOA GEFs [cytosol] (Homo sapiens)
CDC42 GEFs [cytosol] (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
as a member of
RAC2 GEFs [cytosol] (Homo sapiens)
RAC3 GEFs [cytosol] (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
as an input of
EPHB:NMDAR binds TIAM1 (Homo sapiens)
EPHA binds TIAM1 (Homo sapiens)
NTRK2 binds TIAM1 (Homo sapiens)
as a component of
EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 homodimer:TIAM1 [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-Y829-TIAM1 [cytosol]
Inferred To
tiam1a [cytosol]
(Danio rerio)
tiam1 [cytosol]
(Xenopus tropicalis)
Tiam1 [cytosol]
(Mus musculus)
Tiam1 [cytosol]
(Rattus norvegicus)
tiam-1 [cytosol]
(Caenorhabditis elegans)
TIAM1 [cytosol]
(Canis familiaris)
TIAM1 [cytosol]
(Dictyostelium discoideum)
TIAM1 [cytosol]
(Gallus gallus)
TIAM1 [cytosol]
(Sus scrofa)
Ghost homologue of TIAM1 [cytosol]
(Bos taurus)
sif [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
XP_016883936.1
,
XP_005261094.1
,
XP_011528015.1
,
XP_016883937.1
,
NP_003244.2
,
XP_011528014.1
,
XP_016883942.1
,
XP_016883938.1
,
XP_011528013.1
,
XP_016883939.1
,
XP_016883941.1
,
XP_016883940.1
,
XP_005261095.1
OpenTargets
ENSG00000156299
GeneCards
Q13009
HPA
ENSG00000156299-TIAM1
Ensembl
ENST00000455508
,
ENSP00000388217
,
ENSP00000286827
,
ENST00000541036
,
ENSP00000441570
,
ENSG00000156299
,
ENST00000286827
PRO
Q13009
Pharos - Targets
Q13009
HMDB Protein
HMDBP08608
PDB
3KZE
,
4K2O
,
4GVC
,
4NXP
,
4GVD
,
4K2P
,
4NXR
,
3KZD
,
2D8I
,
4NXQ
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.688
3
UniProt:P18827 SDC1
20
SDC1 [lysosomal lumen]
(R-HSA-2090025)
HS(6)-SDC1 [lysosomal lumen]
(R-HSA-2090082)
HS(6)-SDC1 [Golgi lumen]
(R-HSA-2076520)
HS(5)-SDC1 [Golgi lumen]
(R-HSA-2076290)
Heparan-SDC1 [Golgi lumen]
(R-HSA-2076561)
Heparan(1)-SDC1 [Golgi lumen]
(R-HSA-2076349)
Heparan(2)-SDC1 [Golgi lumen]
(R-HSA-2076558)
Heparan(3)-SDC1 [Golgi lumen]
(R-HSA-2076314)
Heparan(4)-SDC1 [Golgi lumen]
(R-HSA-2076339)
HS(1)-SDC1 [Golgi lumen]
(R-HSA-2076321)
HS(2)-SDC1 [Golgi lumen]
(R-HSA-2076309)
HS(4)-SDC1 [Golgi lumen]
(R-HSA-2076593)
HS(3)-SDC1 [Golgi lumen]
(R-HSA-2076444)
GlcA-Gal-Gal-Xyl-SDC1 [Golgi lumen]
(R-HSA-2064082)
Gal-Gal-Xyl-SDC1 [Golgi lumen]
(R-HSA-2064247)
HS(4)-SDC1 [plasma membrane]
(R-HSA-2076693)
HS(6)-SDC1 [plasma membrane]
(R-HSA-2076652)
HS(2)-SDC1 [plasma membrane]
(R-HSA-2076666)
HS(1)-SDC1 [plasma membrane]
(R-HSA-2076672)
HS(3)-SDC1 [plasma membrane]
(R-HSA-2076691)
0.655
5
UniProt:O14936 CASK
1
CASK [cytosol]
(R-HSA-373631)
0.564
2
UniProt:Q9C0A0-1 CNTNAP4
0.558
2
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.527
2
UniProt:P54763 Ephb2
9
phospho-p-Y596,Y602-EPHB2 [plasma membrane]
(R-MMU-3928375)
p-Ephb2 [plasma membrane]
(R-MMU-3928433)
EPHB2 [plasma membrane]
(R-MMU-443809)
EPHB2 (19-?) [extracellular region]
(R-MMU-3928436)
EPHB2 (?-1055) [plasma membrane]
(R-MMU-3928386)
EPHB2 (?-1055) [cytosol]
(R-MMU-3928432)
P54763 [plasma membrane]
(R-MMU-3928394)
Ephb2 [plasma membrane]
(R-MMU-3928443)
p-Y604,Y610-Ephb2 [plasma membrane]
(R-MMU-4093312)
0.524
3
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