Reactome | FOXO4 [nucleoplasm]

FOXO4 [nucleoplasm]

Stable Identifier

R-HSA-5690183

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Forkhead box protein O4, FOXO4_HUMAN

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Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Homo sapiens)
        
        USP7:TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm] (Homo sapiens)
        
        TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm] (Homo sapiens)
        
        FOXO4 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P98177 FOXO4

Gene Names

FOXO4, AFX, AFX1, MLLT7

Chain

chain:1-505

Reference Genes

COSMIC (genes):FOXO4 FOXO4

dbSNP Gene:4303 FOXO4

ENSEMBL:ENSG00000184481 FOXO4

Participates

as a member of

as a component of

as an input of

as an output of

TXN disrupts FOXO4 complex with EP300 (Homo sapiens)

as a candidate of

This entity regulates

Positively

Cdkn1b gene expression is stimulated by FOXO4 (Homo sapiens)

Other forms of this molecule

PolyUb-FOXO4 [nucleoplasm]

Ac-K-FOXO4 [nucleoplasm]

EP300-S-S-FOXO4 [nucleoplasm]

CREBBP-S-S-FOXO4 [nucleoplasm]

SOH-C481-FOXO4 [nucleoplasm]

p-T32,S197,S262-FOXO4 [cytosol]

p-T32,S197,S262-FOXO4 [nucleoplasm]

Inferred To

daf-16 [nucleoplasm] (Caenorhabditis elegans)

foxo [nucleoplasm] (Drosophila melanogaster)

Foxo4 [nucleoplasm] (Mus musculus)

Foxo4 [nucleoplasm] (Rattus norvegicus)

FOXO4 [nucleoplasm] (Bos taurus)

FOXO4 [nucleoplasm] (Canis familiaris)

FOXO4 [nucleoplasm] (Sus scrofa)

foxo4 [nucleoplasm] (Danio rerio)

foxo4 [nucleoplasm] (Xenopus tropicalis)

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.675	4
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.643	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.643	3
UniProt:Q04864 REL	2	REL [cytosol] (R-HSA-1168579) REL [nucleoplasm] (R-HSA-1168585)	0.556	3
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.544	3
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.524	2
UniProt:P98177 FOXO4	8	PolyUb-FOXO4 [nucleoplasm] (R-HSA-6782501) Ac-K-FOXO4 [nucleoplasm] (R-HSA-9617761) EP300-S-S-FOXO4 [nucleoplasm] (R-HSA-9617681) CREBBP-S-S-FOXO4 [nucleoplasm] (R-HSA-9617679) SOH-C481-FOXO4 [nucleoplasm] (R-HSA-9617655) p-T32,S197,S262-FOXO4 [cytosol] (R-HSA-9614415) p-T32,S197,S262-FOXO4 [nucleoplasm] (R-HSA-199314) FOXO4 [nucleoplasm] (R-HSA-5690183)	0.499	2