Reactome | CDC25A [nucleoplasm]

CDC25A [nucleoplasm]

Stable Identifier

R-HSA-143487

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Cdc25A, M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A), M-phase inducer phosphatase 1 , Dual specificity phosphatase Cdc25A

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Disease (Homo sapiens)

- Diseases of programmed cell death (Homo sapiens)
  - Defective Intrinsic Pathway for Apoptosis (Homo sapiens)
    - Neurodegenerative Diseases (Homo sapiens)
      - Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
        
        p25-bound CDK5 phosphorylates CDC25A (Homo sapiens)
        
        CDC25A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P30304 CDC25A

Gene Names

CDC25A

Chain

chain:1-524

Reference Genes

BioGPS Gene:993 CDC25A

COSMIC (genes):CDC25A CDC25A

CTD Gene:993 CDC25A

dbSNP Gene:993 CDC25A

ENSEMBL:ENSG00000164045.12 CDC25A

HGNC:1725 CDC25A

KEGG Gene (Homo sapiens):993 CDC25A

Monarch:993 CDC25A

NCBI Gene:993 CDC25A

OMIM:116947 CDC25A

UCSC:P30304 CDC25A

Reference Transcript

Other Identifiers

0001690075

11726756_a_at

11726757_s_at

11726758_a_at

1555772_PM_a_at

1555772_a_at

16953279

1738_at

204695_PM_at

204695_at

204696_PM_s_at

204696_s_at

2673086

2673087

2673088

2673089

2673091

2673092

2673093

2673094

2673096

2673097

2673098

2673100

2673102

2673104

2673105

2673106

2673107

2673108

35407_at

54538_at

8086880

993

A_23_P121423

A_24_P397107

GE58099

GO:0000079

GO:0000082

GO:0000086

GO:0000278

GO:0004721

GO:0004725

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006470

GO:0007049

GO:0008283

GO:0009314

GO:0010971

GO:0016787

GO:0019901

GO:0022414

GO:0034644

GO:0036211

GO:0043226

GO:0051087

GO:0051301

GO:0110032

GO:0140096

GO:1902751

HMNXSV003034851

HMNXSV003053919

Hs.1634.0.S2_3p_at

Hs2.1634.2.S1_3p_s_at

ILMN_1711005

ILMN_1733396

M81933_at

PH_hs_0000223

TC03001374.hg

g4502704_3p_a_at

Participates

as an input of

as a member of

as an output of

Other forms of this molecule

PolyUb-CDC25A [cytosol]

CDC25A [cytosol]

p-S123-CDC25A [nucleoplasm]

p-S123-CDC25A [cytosol]

p-S40,S116,S261-CDC25A [nucleoplasm]

Inferred To

cdc-25.4 [nucleoplasm] (Caenorhabditis elegans)

Cdc25a [nucleoplasm] (Mus musculus)

Cdc25a [nucleoplasm] (Rattus norvegicus)

cdc25a [nucleoplasm] (Xenopus tropicalis)

cdc25 [nucleoplasm] (Dictyostelium discoideum)

cdc25 [nucleoplasm] (Schizosaccharomyces pombe)

cdc-25.2 [nucleoplasm] (Caenorhabditis elegans)

XB5832479 [nucleoplasm] (Xenopus tropicalis)

cdc-25.3 [nucleoplasm] (Caenorhabditis elegans)

cdc-25.1 [nucleoplasm] (Caenorhabditis elegans)

cdc25b [nucleoplasm] (Xenopus tropicalis)

MIH1 [nucleoplasm] (Saccharomyces cerevisiae)

CDC25A [nucleoplasm] (Bos taurus)

CDC25A [nucleoplasm] (Canis familiaris)

CDC25A [nucleoplasm] (Danio rerio)

CDC25A [nucleoplasm] (Gallus gallus)

CDC25A [nucleoplasm] (Sus scrofa)

Homologues of CDC25A [nucleoplasm] (Caenorhabditis elegans)

Homologues of CDC25A [nucleoplasm] (Drosophila melanogaster)

Homologues of CDC25A [nucleoplasm] (Xenopus tropicalis)

twe [nucleoplasm] (Drosophila melanogaster)

stg [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_963861.1, XP_011532618.1, NP_001780.2

ZINC - World Drugs

MPIP1_HUMAN

OpenTargets

ENSG00000164045

ZINC - FDA approved

MPIP1_HUMAN

ZINC - Substances

MPIP1_HUMAN

ZINC - Biogenic

MPIP1_HUMAN

ZINC target

P30304

PRO

P30304

PDB

1C25

ZINC - Metabolites

MPIP1_HUMAN

IntEnz

3.1.3.48

GeneCards

P30304

HPA

ENSG00000164045-CDC25A

Ensembl

ENST00000351231, ENSP00000303706, ENSG00000164045, ENST00000302506, ENSP00000343166

Pharos - Targets

P30304

ZINC - Predictions - Purchasable

MPIP1_HUMAN

HMDB Protein

HMDBP08919

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UKB1 FBXW11	1	FBXW11 [cytosol] (R-HSA-976035)	0.763	5
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.763	5
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.701	10
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.69	5
UniProt:O96017 CHEK2	3	CHEK2 [nucleoplasm] (R-HSA-113824) p-T68-CHEK2 [nucleoplasm] (R-HSA-113825) p-S,3T-CHEK2 [nucleoplasm] (R-HSA-5683784)	0.623	2
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.569	3
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.569	3
UniProt:Q9BSU3 NAA11			0.556	3
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.544	2

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