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CDC25A [nucleoplasm]
Stable Identifier
R-HSA-143487
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cdc25A, M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A), M-phase inducer phosphatase 1 , Dual specificity phosphatase Cdc25A
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G1/S DNA Damage Checkpoints (Homo sapiens)
p53-Independent G1/S DNA damage checkpoint (Homo sapiens)
p53-Independent DNA Damage Response (Homo sapiens)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Homo sapiens)
Phosphorylation of Cdc25A at Ser-123 by Chk1 (Homo sapiens)
CDC25A [nucleoplasm] (Homo sapiens)
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Homo sapiens)
CDC25A [nucleoplasm] (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
Activation of ATR in response to replication stress (Homo sapiens)
Phosphorylation of Cdc25A at Ser-123 by Chk1 (Homo sapiens)
CDC25A [nucleoplasm] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G0 and Early G1 (Homo sapiens)
Transcription of E2F targets under negative control by DREAM complex (Homo sapiens)
The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex (Homo sapiens)
CDC25A [nucleoplasm] (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Homo sapiens)
CDC25A [nucleoplasm] (Homo sapiens)
The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex (Homo sapiens)
CDC25A [nucleoplasm] (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
Cyclin A/B1/B2 associated events during G2/M transition (Homo sapiens)
Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Homo sapiens)
CDC25A [nucleoplasm] (Homo sapiens)
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Homo sapiens)
CDC25 [nucleoplasm] (Homo sapiens)
CDC25A [nucleoplasm] (Homo sapiens)
Translocation of Cdc25 to the nucleus (Homo sapiens)
CDC25 [nucleoplasm] (Homo sapiens)
CDC25A [nucleoplasm] (Homo sapiens)
Polo-like kinase mediated events (Homo sapiens)
FOXM1 stimulates CDC25A transcription (Homo sapiens)
CDC25A [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Homo sapiens)
Cdc25 A/B [nucleoplasm] (Homo sapiens)
CDC25A [nucleoplasm] (Homo sapiens)
The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex (Homo sapiens)
CDC25A [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of programmed cell death (Homo sapiens)
Neurodegenerative Diseases (Homo sapiens)
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
p25-bound CDK5 phosphorylates CDC25A (Homo sapiens)
CDC25A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P30304 CDC25A
Gene Names
CDC25A
Chain
chain:1-524
Reference Genes
BioGPS Gene:993 CDC25A
COSMIC (genes):CDC25A CDC25A
CTD Gene:993 CDC25A
dbSNP Gene:993 CDC25A
ENSEMBL:ENSG00000164045 CDC25A
HGNC:1725 CDC25A
KEGG Gene (Homo sapiens):993 CDC25A
Monarch:993 CDC25A
NCBI Gene:993 CDC25A
OMIM:116947 CDC25A
UCSC:P30304 CDC25A
Reference Transcript
RefSeq:NM_201567.1 CDC25A
RefSeq:NM_001789.2 CDC25A
RefSeq:XM_011534316.1 CDC25A
Other Identifiers
0001690075
11726756_a_at
11726757_s_at
11726758_a_at
1555772_a_at
16953279
1738_at
204695_at
204696_s_at
2673086
2673087
2673088
2673089
2673091
2673092
2673093
2673094
2673096
2673097
2673098
2673100
2673102
2673104
2673105
2673106
2673107
2673108
35407_at
54538_at
8086880
993
A_23_P121423
A_24_P397107
GE58099
GO:0000003
GO:0000079
GO:0000082
GO:0000086
GO:0000278
GO:0003674
GO:0004721
GO:0004725
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006464
GO:0006470
GO:0007049
GO:0008150
GO:0008283
GO:0009314
GO:0010971
GO:0016579
GO:0016787
GO:0016791
GO:0019899
GO:0019901
GO:0034644
GO:0035335
GO:0043226
GO:0045931
GO:0051087
GO:0051301
GO:0051726
GO:0110032
GO:1902751
Hs.1634.0.S2_3p_at
Hs2.1634.2.S1_3p_s_at
ILMN_1711005
ILMN_1733396
M81933_at
PH_hs_0000223
TC03001374.hg
g4502704_3p_a_at
Participant Of
input
p25-bound CDK5 phosphorylates CDC25A
Phosphorylation of Cdc25A at Ser-123 by Chk1
Phosphorylation of Cdc25A at Ser-123 by Chk2
output
FOXM1 stimulates CDC25A transcription
The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex
hasMember
CDC25 [nucleoplasm]
Cdc25 A/B [nucleoplasm]
Other forms of this molecule
p-S123-CDC25A [nucleoplasm]
CDC25A [cytosol]
p-S123-CDC25A [cytosol]
p-S40,S116,S261-CDC25A [nucleoplasm]
PolyUb-CDC25A [cytosol]
Inferred To
cdc-25.4 [nucleoplasm] (Caenorhabditis elegans)
Cdc25a [nucleoplasm] (Mus musculus)
Cdc25a [nucleoplasm] (Rattus norvegicus)
cdc25a [nucleoplasm] (Xenopus tropicalis)
cdc25d [nucleoplasm] (Danio rerio)
cdc25 [nucleoplasm] (Dictyostelium discoideum)
cdc25 [nucleoplasm] (Schizosaccharomyces pombe)
cdc-25.2 [nucleoplasm] (Caenorhabditis elegans)
cdc-25.3 [nucleoplasm] (Caenorhabditis elegans)
cdc-25.1 [nucleoplasm] (Caenorhabditis elegans)
cdc25b [nucleoplasm] (Danio rerio)
MIH1 [nucleoplasm] (Saccharomyces cerevisiae)
CDC25A [nucleoplasm] (Canis familiaris)
CDC25A [nucleoplasm] (Gallus gallus)
CDC25A [nucleoplasm] (Sus scrofa)
Homologues of CDC25A [nucleoplasm] (Caenorhabditis elegans)
Homologues of CDC25A [nucleoplasm] (Danio rerio)
Homologues of CDC25A [nucleoplasm] (Drosophila melanogaster)
twe [nucleoplasm] (Drosophila melanogaster)
stg [nucleoplasm] (Drosophila melanogaster)
Cross References
RefSeq
XP_011532618.1
,
NP_963861.1
,
NP_001780.2
ZINC - World Drugs
MPIP1_HUMAN
OpenTargets
ENSG00000164045
ZINC - FDA approved
MPIP1_HUMAN
ZINC - Substances
MPIP1_HUMAN
ZINC target
P30304
ZINC - Biogenic
MPIP1_HUMAN
PRO
P30304
PDB
1C25
ZINC - Metabolites
MPIP1_HUMAN
GeneCards
P30304
HPA
ENSG00000164045-CDC25A
Ensembl
ENST00000302506
,
ENSP00000303706
,
ENST00000351231
,
ENSP00000343166
,
ENSG00000164045
ZINC - Predictions - Purchasable
MPIP1_HUMAN
HMDB Protein
HMDBP08919
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UKB1 FBXW11
1
FBXW11 [cytosol]
(R-HSA-976035)
0.708
4
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.706
10
UniProt:Q9Y297 BTRC
2
BTRC [nucleoplasm]
(R-HSA-3361753)
BTRC [cytosol]
(R-HSA-174237)
0.691
4
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.69
5
UniProt:O96017 CHEK2
3
p-T68-CHEK2 [nucleoplasm]
(R-HSA-113825)
p-S,3T-CHEK2 [nucleoplasm]
(R-HSA-5683784)
CHEK2 [nucleoplasm]
(R-HSA-113824)
0.623
2
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.597
3
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.597
3
UniProt:Q9BSU3 NAA11
0.556
3
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.544
2
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.462
2
UniProt:P30101 PDIA3
3
PDIA3 [recycling endosome membrane]
(R-HSA-8863849)
PDIA3 [phagocytic vesicle]
(R-HSA-1236870)
PDIA3 [endoplasmic reticulum lumen]
(R-HSA-901028)
0.462
2
UniProt:P63208 SKP1
2
SKP1 [cytosol]
(R-HSA-174150)
SKP1 [nucleoplasm]
(R-HSA-187538)
0.462
2
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