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USP8 [cytosol]
Stable Identifier
R-HSA-917720
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
UBPY, Ubiquitin carboxyl-terminal hydrolase 8, UBP8_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP8 deubiquitinates RNF128 (Homo sapiens)
USP8:K48polyUb-RNF128:OTUB1 [cytosol] (Homo sapiens)
USP8 [cytosol] (Homo sapiens)
USP8:RNF128:OTUB1 [cytosol] (Homo sapiens)
USP8 [cytosol] (Homo sapiens)
USP8 deubiquitinates STAM2:HGS (Homo sapiens)
USP8:STAM2:HGS [cytosol] (Homo sapiens)
USP8 [cytosol] (Homo sapiens)
USP8:Ub-STAM2:HGS [cytosol] (Homo sapiens)
USP8 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB2 (Homo sapiens)
Downregulation of ERBB2 signaling (Homo sapiens)
Downregulation of ERBB2:ERBB3 signaling (Homo sapiens)
Phosphorylation of USP8 by P-AKT (Homo sapiens)
USP8 [cytosol] (Homo sapiens)
Signaling by MET (Homo sapiens)
Negative regulation of MET activity (Homo sapiens)
USP8 deubiquitinates LRIG1 (Homo sapiens)
USP8 [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Regulation of FZD by ubiquitination (Homo sapiens)
USP8 deubiquitinates FZD to potentiate WNT signaling (Homo sapiens)
USP8 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P40818 USP8
Gene Names
USP8, KIAA0055, UBPY
Chain
chain:1-1118
Reference Genes
BioGPS Gene:9101 USP8
COSMIC (genes):USP8 USP8
CTD Gene:9101 USP8
dbSNP Gene:9101 USP8
ENSEMBL:ENSG00000138592.14 USP8
HGNC:12631 USP8
KEGG Gene (Homo sapiens):9101 USP8
Monarch:9101 USP8
NCBI Gene:9101 USP8
OMIM:603158 USP8
UCSC:P40818 USP8
Reference Transcript
RefSeq:NM_001128610.2 USP8
RefSeq:NM_005154.4 USP8
RefSeq:XM_011522193.2 USP8
RefSeq:XM_006720761.3 USP8
RefSeq:NM_001283049.1 USP8
Other Identifiers
0003360739
11724333_a_at
11724334_a_at
11724335_s_at
11726705_a_at
16800991
202745_PM_at
202745_at
229501_PM_s_at
229501_s_at
2580459
2902230
2902232
2902237
2902238
2902240
2902242
2902244
3593653
3593654
3593655
3593658
3593659
3593662
3593665
3593667
3593668
3593671
3593677
3593678
3593679
3593680
3593681
3593682
3593683
3593685
3593688
3593689
3593691
3593693
3593694
3593695
3593698
3593700
3593701
3593702
3593707
3593709
3593711
39794_at
43467_at
50904_g_at
7983663
9101
A_14_P124443
A_23_P129058
D29956_at
GE57157
GO:0000278
GO:0000281
GO:0000910
GO:0004197
GO:0004843
GO:0005515
GO:0005622
GO:0005634
GO:0005737
GO:0005768
GO:0005769
GO:0005829
GO:0005886
GO:0006508
GO:0006511
GO:0007032
GO:0007049
GO:0007265
GO:0008233
GO:0008234
GO:0010008
GO:0014069
GO:0016020
GO:0016579
GO:0016787
GO:0017124
GO:0019897
GO:0023052
GO:0030163
GO:0030496
GO:0031313
GO:0031410
GO:0031647
GO:0032880
GO:0036211
GO:0043197
GO:0043226
GO:0045296
GO:0070536
GO:0071108
GO:0071549
GO:0090263
GO:0098978
GO:0099576
GO:0101005
GO:0110165
GO:0140096
GO:1990090
HMNXSV003003858
Hs.152818.1.A1_3p_a_at
ILMN_1715188
ILMN_2094587
PH_hs_0029238
TC15000395.hg
g4827053_3p_at
Participates
as a component of
USP8:STAM2:HGS [cytosol] (Homo sapiens)
USP8:Ub-STAM2:HGS [cytosol] (Homo sapiens)
USP8:RNF128:OTUB1 [cytosol] (Homo sapiens)
USP8:K48polyUb-RNF128:OTUB1 [cytosol] (Homo sapiens)
as an input of
Phosphorylation of USP8 by P-AKT (Homo sapiens)
Other forms of this molecule
p-T945-USP8 [cytosol]
Inferred To
Usp8 [cytosol]
(Drosophila melanogaster)
Usp8 [cytosol]
(Mus musculus)
Usp8 [cytosol]
(Rattus norvegicus)
USP8 [cytosol]
(Bos taurus)
USP8 [cytosol]
(Canis familiaris)
USP8 [cytosol]
(Danio rerio)
USP8 [cytosol]
(Gallus gallus)
USP8 [cytosol]
(Plasmodium falciparum)
USP8 [cytosol]
(Sus scrofa)
usp8 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001122082.1
,
XP_006720824.1
,
NP_005145.3
,
NP_001269978.1
,
XP_011520495.1
OpenTargets
ENSG00000138592
IntEnz
3.4.19.12
GeneCards
P40818
HPA
ENSG00000138592-USP8
Ensembl
ENSG00000138592
,
ENST00000396444
,
ENSP00000379721
,
ENST00000425032
,
ENSP00000302239
,
ENSP00000412682
,
ENST00000307179
ZINC target
P40818
PRO
P40818
Pharos - Targets
P40818
Orphanet
22898
PDB
2GFO
,
2A9U
,
2GWF
,
1WHB
,
6F09
,
3N3K
HMDB Protein
HMDBP10136
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.77
4
UniProt:O89100 Grap2
2
Grap2 [cytosol]
(R-MMU-9680624)
Grap2 [cytosol]
(R-MMU-202367)
0.75
4
UniProt:Q7LBR1 CHM1B
0.698
5
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.688
3
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.688
3
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.688
4
UniProt:Q9HD42 CHMP1A
1
CHMP1A [cytosol]
(R-HSA-917721)
0.667
3
IntAct:EBI-4399559 UBIQ
0.623
2
UniProt:Q96CF2 CHMP4C
2
CHMP4C [endosome membrane]
(R-HSA-9631186)
CHMP4C [cytosol]
(R-HSA-917710)
0.609
2
UniProt:Q99814 EPAS1
5
HN-EPAS1 [cytosol]
(R-HSA-1234112)
2xHP-EPAS1 [nucleoplasm]
(R-HSA-1234151)
2xHP-EPAS1 [cytosol]
(R-HSA-1234149)
EPAS1 [nucleoplasm]
(R-HSA-452560)
EPAS1 [cytosol]
(R-HSA-1234119)
0.544
2
UniProt:Q16665 HIF1A
7
HN-HIF1A [cytosol]
(R-HSA-1234110)
2xHP-HIF1A [nucleoplasm]
(R-HSA-1234105)
2xHP-HIF1A [cytosol]
(R-HSA-1234131)
p-Y565,S797-HIF1A [cytosol]
(R-HSA-9634700)
p-Y565-HIF1A [cytosol]
(R-HSA-8857584)
HIF1A [cytosol]
(R-HSA-1234102)
HIF1A [nucleoplasm]
(R-HSA-1234135)
0.544
2
UniProt:Q14596 NBR1
2
NBR1 [peroxisomal membrane]
(R-HSA-9665177)
NBR1 [cytosol]
(R-HSA-9665180)
0.543
3
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.527
2
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