Reactome | USP8 [cytosol]

USP8 [cytosol]

Stable Identifier

R-HSA-917720

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

UBPY, Ubiquitin carboxyl-terminal hydrolase 8, UBP8_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P40818 USP8

Gene Names

USP8, KIAA0055, UBPY

Chain

chain:1-1118

Reference Genes

BioGPS Gene:9101 USP8

COSMIC (genes):USP8 USP8

CTD Gene:9101 USP8

dbSNP Gene:9101 USP8

ENSEMBL:ENSG00000138592 USP8

HGNC:12631 USP8

KEGG Gene (Homo sapiens):9101 USP8

Monarch:9101 USP8

NCBI Gene:9101 USP8

OMIM:603158 USP8

UCSC:P40818 USP8

Reference Transcript

Other Identifiers

0003360739

11724333_a_at

11724334_a_at

11724335_s_at

11726705_a_at

16800991

1WHB

202745_at

229501_s_at

2580459

2902230

2902232

2902237

2902238

2902240

2902242

2902244

2A9U

2GFO

2GWF

3593653

3593654

3593655

3593658

3593659

3593662

3593665

3593667

3593668

3593671

3593677

3593678

3593679

3593680

3593681

3593682

3593683

3593685

3593688

3593689

3593691

3593693

3593694

3593695

3593698

3593700

3593701

3593702

3593707

3593709

3593711

39794_at

3N3K

43467_at

50215

50904_g_at

6F09

7983663

9101

A0A024R5S4

A0A075B720

A_14_P124443

A_23_P129058

AAH38801

AAH51345

AAI10591

AC012170

AK296480

BAA06225

BAG59120

BC038801

BC051345

BC110590

BX537420

CAD97662

CCDS10137

CCDS61632

CH471082

D29956

D29956_at

EAW77399

EAW77400

EAW77401

ENSG00000138592

ENSP00000302239

ENSP00000379721

ENSP00000412682

ENST00000307179

ENST00000396444

ENST00000396444.7

ENST00000425032

ENST00000425032.7

EntrezGene:9101

EntrezGene:USP8

g4827053_3p_at

GE57157

GO:0000278

GO:0000281

GO:0003674

GO:0004197

GO:0004843

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005768

GO:0005769

GO:0005829

GO:0005886

GO:0006464

GO:0006508

GO:0006511

GO:0007032

GO:0007049

GO:0007165

GO:0007265

GO:0007267

GO:0008150

GO:0008233

GO:0008234

GO:0009056

GO:0010008

GO:0014069

GO:0016020

GO:0016579

GO:0016787

GO:0017124

GO:0019897

GO:0030496

GO:0031313

GO:0031410

GO:0031647

GO:0032880

GO:0036459

GO:0043197

GO:0043226

GO:0045296

GO:0051301

GO:0070536

GO:0071108

GO:0071549

GO:0090263

GO:0098978

GO:0099576

GO:1990090

H0YKV1

H0YLH2

H0YLS3

H0YM17

H0YM47

H0YNL5

HGNC:12631

HPA050215

Hs.152818.1.A1_3p_a_at

ILMN_1715188

ILMN_2094587

IPR001394

IPR001763

IPR015063

IPR018200

IPR028889

IPR036873

IPR038765

MIM:219090

MIM:603158

NM_001128610

NM_001283049

NM_005154

NP_001122082

NP_001269978

NP_005145

PF00443

PF00581

PF08969

PH_hs_0029238

TC15000395.hg

UPI0000030306

UPI00017A75E8

USP8

USP8-201

USP8-202

USP8-204

XM_006720761

XM_006720762

XM_011522193

XM_017022718

XM_017022719

XM_017022720

XM_017022721

XM_017022722

XM_024450098

XP_006720824

XP_006720825

XP_011520495

XP_016878207

XP_016878208

XP_016878209

XP_016878210

XP_016878211

XP_024305866

Participant Of

hasComponent

input

Phosphorylation of USP8 by P-AKT

Other forms of this molecule

p-T945-USP8 [cytosol]

Inferred To

Homologues of USP8 [cytosol] (Dictyostelium discoideum)

Homologues of USP8 [cytosol] (Plasmodium falciparum)

Homologues of USP8 [cytosol] (Saccharomyces cerevisiae)

Homologues of USP8 [cytosol] (Schizosaccharomyces pombe)

USP8 [cytosol] (Bos taurus)

USP8 [cytosol] (Canis familiaris)

USP8 [cytosol] (Danio rerio)

USP8 [cytosol] (Dictyostelium discoideum)

USP8 [cytosol] (Gallus gallus)

USP8 [cytosol] (Mus musculus)

USP8 [cytosol] (Plasmodium falciparum)

USP8 [cytosol] (Rattus norvegicus)

USP8 [cytosol] (Saccharomyces cerevisiae)

USP8 [cytosol] (Schizosaccharomyces pombe)

USP8 [cytosol] (Sus scrofa)

USP8 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001122082.1, NP_001269978.1, XP_011520495.1, XP_006720824.1, NP_005145.3

OpenTargets

ENSG00000138592

GeneCards

P40818

ZINC target

P40818

PRO

P40818

Orphanet

22898

HMDB Protein

HMDBP10136

PDB

2A9U, 3N3K, 2GFO, 6F09, 2GWF, 1WHB

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.77	4
UniProt:O89100	1	GRAP2 [cytosol] (R-MMU-202367)	0.75	4
UniProt:Q7LBR1 CHM1B			0.698	5
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.688	4
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.688	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.688	3
UniProt:Q9HD42 CHMP1A	1	CHMP1A [cytosol] (R-HSA-917721)	0.667	3
IntAct:EBI-4399559 UBIQ			0.623	2
UniProt:Q96CF2 CHMP4C	2	CHMP4C [cytosol] (R-HSA-917710) CHMP4C [endosome membrane] (R-HSA-9631186)	0.609	2
UniProt:Q99814 EPAS1	5	EPAS1 [cytosol] (R-HSA-1234119) EPAS1 [nucleoplasm] (R-HSA-452560) 2xHP-EPAS1 [cytosol] (R-HSA-1234149) 2xHP-EPAS1 [nucleoplasm] (R-HSA-1234151) HN-EPAS1 [cytosol] (R-HSA-1234112)	0.544	2
UniProt:Q16665 HIF1A	7	2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) HN-HIF1A [cytosol] (R-HSA-1234110) 2xHP-HIF1A [cytosol] (R-HSA-1234131) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) p-Y565-HIF1A [cytosol] (R-HSA-8857584) HIF1A [cytosol] (R-HSA-1234102) HIF1A [nucleoplasm] (R-HSA-1234135)	0.544	2
UniProt:Q14596 NBR1			0.543	3
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.527	2