Reactome | USP8 [cytosol]

USP8 [cytosol]

Stable Identifier

R-HSA-917720

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

UBPY, Ubiquitin carboxyl-terminal hydrolase 8, UBP8_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P40818 USP8

Gene Names

USP8, KIAA0055, UBPY

Chain

chain:1-1118

Reference Genes

BioGPS Gene:9101 USP8

COSMIC (genes):USP8 USP8

CTD Gene:9101 USP8

dbSNP Gene:9101 USP8

ENSEMBL:ENSG00000138592 USP8

HGNC:12631 USP8

KEGG Gene (Homo sapiens):9101 USP8

Monarch:9101 USP8

NCBI Gene:9101 USP8

OMIM:603158 USP8

UCSC:P40818 USP8

Reference Transcript

Other Identifiers

0003360739

11724333_a_at

11724334_a_at

11724335_s_at

11726705_a_at

16800991

202745_at

229501_s_at

2580459

2902230

2902232

2902237

2902238

2902240

2902242

2902244

3593653

3593654

3593655

3593658

3593659

3593662

3593665

3593667

3593668

3593671

3593677

3593678

3593679

3593680

3593681

3593682

3593683

3593685

3593688

3593689

3593691

3593693

3593694

3593695

3593698

3593700

3593701

3593702

3593707

3593709

3593711

39794_at

43467_at

50904_g_at

7983663

9101

A_14_P124443

A_23_P129058

D29956_at

GE57157

GO:0000278

GO:0000281

GO:0003674

GO:0004197

GO:0004843

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005768

GO:0005769

GO:0005829

GO:0005886

GO:0006464

GO:0006508

GO:0006511

GO:0007032

GO:0007049

GO:0007165

GO:0007265

GO:0007267

GO:0008150

GO:0008233

GO:0008234

GO:0009056

GO:0010008

GO:0014069

GO:0016020

GO:0016579

GO:0016787

GO:0017124

GO:0019897

GO:0030496

GO:0031313

GO:0031410

GO:0031647

GO:0032880

GO:0043197

GO:0043226

GO:0045296

GO:0051301

GO:0070536

GO:0071108

GO:0071549

GO:0090263

GO:0098978

GO:0099576

GO:1990090

HMNXSV003003858

Hs.152818.1.A1_3p_a_at

ILMN_1715188

ILMN_2094587

PH_hs_0029238

TC15000395.hg

g4827053_3p_at

Participates

as a component of

as an input of

Phosphorylation of USP8 by P-AKT (Homo sapiens)

Other forms of this molecule

p-T945-USP8 [cytosol]

Inferred To

Homologues of USP8 [cytosol] (Dictyostelium discoideum)

Homologues of USP8 [cytosol] (Plasmodium falciparum)

Homologues of USP8 [cytosol] (Saccharomyces cerevisiae)

Homologues of USP8 [cytosol] (Schizosaccharomyces pombe)

DOA4 [cytosol] (Saccharomyces cerevisiae)

Usp8 [cytosol] (Drosophila melanogaster)

Usp8 [cytosol] (Mus musculus)

Usp8 [cytosol] (Rattus norvegicus)

ubp12 [cytosol] (Schizosaccharomyces pombe)

ubp1 [cytosol] (Schizosaccharomyces pombe)

USP8 [cytosol] (Bos taurus)

USP8 [cytosol] (Canis familiaris)

USP8 [cytosol] (Dictyostelium discoideum)

USP8 [cytosol] (Gallus gallus)

USP8 [cytosol] (Plasmodium falciparum)

USP8 [cytosol] (Sus scrofa)

USP8 [cytosol] (Xenopus tropicalis)

usp8 [cytosol] (Danio rerio)

UBP12 [cytosol] (Saccharomyces cerevisiae)

UBP5 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001122082.1, XP_006720824.1, XP_011520495.1, NP_005145.3, NP_001269978.1

OpenTargets

ENSG00000138592

HPA

ENSG00000138592-USP8

GeneCards

P40818

ZINC target

P40818

Ensembl

ENST00000396444, ENSG00000138592, ENSP00000379721, ENST00000425032, ENSP00000302239, ENSP00000412682, ENST00000307179

PRO

P40818

Pharos - Targets

P40818

Orphanet

22898

HMDB Protein

HMDBP10136

PDB

2A9U, 2GFO, 6F09, 1WHB, 3N3K, 2GWF

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.77	4
UniProt:O89100	1	Grap2 [cytosol] (R-MMU-202367)	0.75	4
UniProt:Q7LBR1 CHM1B			0.698	5
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.688	3
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.688	3
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.688	4
UniProt:Q9HD42 CHMP1A	1	CHMP1A [cytosol] (R-HSA-917721)	0.667	3
IntAct:EBI-4399559 UBIQ			0.623	2
UniProt:Q96CF2 CHMP4C	2	CHMP4C [cytosol] (R-HSA-917710) CHMP4C [endosome membrane] (R-HSA-9631186)	0.609	2
UniProt:Q16665 HIF1A	7	p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) 2xHP-HIF1A [cytosol] (R-HSA-1234131) HIF1A [cytosol] (R-HSA-1234102) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) HIF1A [nucleoplasm] (R-HSA-1234135) p-Y565-HIF1A [cytosol] (R-HSA-8857584) HN-HIF1A [cytosol] (R-HSA-1234110)	0.544	2
UniProt:Q99814 EPAS1	5	HN-EPAS1 [cytosol] (R-HSA-1234112) EPAS1 [nucleoplasm] (R-HSA-452560) 2xHP-EPAS1 [cytosol] (R-HSA-1234149) EPAS1 [cytosol] (R-HSA-1234119) 2xHP-EPAS1 [nucleoplasm] (R-HSA-1234151)	0.544	2
UniProt:Q14596 NBR1	2	NBR1 [peroxisomal membrane] (R-HSA-9665177) NBR1 [cytosol] (R-HSA-9665180)	0.543	3
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.527	2

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