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iRHOM2 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-9662859
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
CD163 mediating an anti-inflammatory response (Homo sapiens)
iRHOM2 transports ADAM17 from ER to the Golgi-network (Homo sapiens)
iRHOM2 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q6PJF5 RHBDF2
Gene Names
RHBDF2, IRHOM2, RHBDL5, RHBDL6
Chain
chain:1-856
Reference Genes
BioGPS Gene:79651 RHBDF2
COSMIC (genes):RHBDF2 RHBDF2
CTD Gene:79651 RHBDF2
dbSNP Gene:79651 RHBDF2
ENSEMBL:ENSG00000129667 RHBDF2
HGNC:20788 RHBDF2
Monarch:79651 RHBDF2
NCBI Gene:79651 RHBDF2
OMIM:614404 RHBDF2
UCSC:Q6PJF5 RHBDF2
Reference Transcript
RefSeq:XM_011525251.2 RHBDF2
RefSeq:XM_005257670.1 RHBDF2
RefSeq:NM_024599.5 RHBDF2
RefSeq:XM_017025079.1 RHBDF2
RefSeq:XM_005257669.3 RHBDF2
RefSeq:XM_011525250.2 RHBDF2
RefSeq:XM_011525249.2 RHBDF2
RefSeq:NM_001005498.3 RHBDF2
Other Identifiers
11739795_a_at
11739796_a_at
11749501_a_at
16849238
219202_PM_at
219202_at
3771603
3771604
3771606
3771607
3771608
3771609
3771610
3771611
3771612
3771613
3771614
3771615
3771616
3771617
3771618
3771619
3771621
3771622
3771623
3771624
3771625
3771626
3771627
3771628
3771629
3771630
3771631
3771632
3771633
3771634
3771636
3771640
3771641
50427_at
79651
8018731
GE56928
GO:0002862
GO:0003824
GO:0004252
GO:0005215
GO:0005515
GO:0005783
GO:0005789
GO:0005796
GO:0005886
GO:0015031
GO:0016020
GO:0016787
GO:0019838
GO:0042058
GO:0043226
GO:0050708
GO:0050709
GO:0072659
GO:0140096
GO:0140318
HMNXSV003026326
HMNXSV003056795
ILMN_1691717
ILMN_1735792
ILMN_2373062
PH_hs_0002241
TC17001899.hg
g13375798_3p_at
Other forms of this molecule
iRHOM2 [Golgi lumen]
Cross References
ENSEMBL
ENST00000675367
,
ENSP00000466867
,
ENSP00000501790
,
ENSP00000322775
,
ENST00000313080
,
ENST00000591885
OpenTargets
ENSG00000129667
HPA
ENSG00000129667-RHBDF2
PRO
Q6PJF5
Pharos - Targets
Q6PJF5
GlyGen
Q6PJF5
HMDB Protein
HMDBP13414
PDB
8SNO
,
8SNM
,
8SNL
,
8SNN
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.527
2
UniProt:P37173 TGFBR2
9
TGFBR2 [plasma membrane]
(R-HSA-170842)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 K128Sfs*35 [cytosol]
(R-HSA-3642166)
TGFBR2 K128Afs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
0.527
2
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