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TSC1 [plasma membrane]
Stable Identifier
R-HSA-165169
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Metabolic Genes (Homo sapiens)
Formation of TSC1:TSC2 complex (Homo sapiens)
TSC1 [plasma membrane] (Homo sapiens)
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Homo sapiens)
TSC1:p-S1387-TSC2 [plasma membrane] (Homo sapiens)
TSC1 [plasma membrane] (Homo sapiens)
p-AMPK phosphorylates TSC1:TSC2 (Homo sapiens)
TSC1:p-S1387-TSC2 [plasma membrane] (Homo sapiens)
TSC1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
MTOR signalling (Homo sapiens)
Energy dependent regulation of mTOR by LKB1-AMPK (Homo sapiens)
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Homo sapiens)
TSC1:p-S1387-TSC2 [plasma membrane] (Homo sapiens)
TSC1 [plasma membrane] (Homo sapiens)
p-AMPK phosphorylates TSC1:TSC2 (Homo sapiens)
TSC1:p-S1387-TSC2 [plasma membrane] (Homo sapiens)
TSC1 [plasma membrane] (Homo sapiens)
Inhibition of TSC complex formation by PKB (Homo sapiens)
Phosphorylation of complexed TSC2 by PKB (Homo sapiens)
TSC1:Inhibited TSC2-1-P [cytosol] (Homo sapiens)
TSC1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92574 TSC1
Gene Names
TSC1, KIAA0243, TSC
Chain
chain:1-1164
Reference Genes
BioGPS Gene:7248 TSC1
COSMIC (genes):TSC1 TSC1
CTD Gene:7248 TSC1
dbSNP Gene:7248 TSC1
ENSEMBL:ENSG00000165699 TSC1
HGNC:12362 TSC1
KEGG:hsa:7248 TSC1
Monarch:7248 TSC1
NCBI Gene:7248 TSC1
OMIM:605284 TSC1
UCSC:Q92574 TSC1
Reference Transcript
RefSeq:NM_001162427.1 TSC1
RefSeq:XM_017015096.1 TSC1
RefSeq:NM_001162426.1 TSC1
RefSeq:XM_017015097.1 TSC1
RefSeq:XM_006717271.1 TSC1
RefSeq:NM_000368.4 TSC1
RefSeq:XM_005272211.1 TSC1
RefSeq:XM_011518979.2 TSC1
Other Identifiers
11718819_a_at
11718820_at
11739935_a_at
11759981_x_at
17099361
209390_PM_at
209390_at
3228372
3228374
3228375
3228376
3228377
3228378
3228379
3228380
3228381
3228382
3228383
3228384
3228385
3228387
3228388
3228389
3228390
3228391
3228392
3228393
3228394
3228395
3228396
3228397
3228398
3228399
3228400
3228401
3228403
3228404
3228405
3228406
3228407
3228408
3228409
3228410
3228411
3228412
3228413
3228414
3228416
3228417
32599_at
55939_at
7248
8164781
A_24_P329635
A_33_P3359373
D87683_at
GE54118
GE631547
GE80217
GO:0000054
GO:0001822
GO:0001843
GO:0001952
GO:0002250
GO:0002376
GO:0005515
GO:0005634
GO:0005737
GO:0005764
GO:0005765
GO:0005773
GO:0005811
GO:0005829
GO:0005884
GO:0005886
GO:0005938
GO:0006417
GO:0006457
GO:0006813
GO:0006913
GO:0007155
GO:0007160
GO:0007399
GO:0008283
GO:0008285
GO:0008306
GO:0008344
GO:0009267
GO:0014069
GO:0016020
GO:0016242
GO:0017148
GO:0021766
GO:0021987
GO:0030027
GO:0030030
GO:0030154
GO:0030544
GO:0032007
GO:0032780
GO:0032868
GO:0032991
GO:0033596
GO:0034330
GO:0036294
GO:0042030
GO:0042552
GO:0043226
GO:0043379
GO:0043666
GO:0044183
GO:0045792
GO:0046323
GO:0048471
GO:0048856
GO:0050808
GO:0050821
GO:0050877
GO:0051087
GO:0051492
GO:0051726
GO:0051879
GO:0051894
GO:0055007
GO:0055085
GO:0090630
GO:0098772
GO:0101031
GO:1904262
HMNXSV003039900
HMNXSV003054774
HMNXSV003055583
Hs.69429.0.S1_3p_at
ILMN_1754871
ILMN_1758378
ILMN_1797367
ILMN_2246510
PH_hs_0022176
TC09001678.hg
g2331280_3p_at
Participates
as a component of
TSC1:Inhibited TSC2-1-P [cytosol] (Homo sapiens)
TSC1:p-S1387-TSC2 [plasma membrane] (Homo sapiens)
as an input of
Formation of TSC1:TSC2 complex (Homo sapiens)
Other forms of this molecule
TSC1 [cytosol]
Inferred To
tsc1 [plasma membrane]
(Schizosaccharomyces pombe)
tsc1 [plasma membrane]
(Xenopus tropicalis)
TSC1 [plasma membrane]
(Bos taurus)
TSC1 [plasma membrane]
(Canis familiaris)
TSC1 [plasma membrane]
(Sus scrofa)
Tsc1 [plasma membrane]
(Drosophila melanogaster)
Tsc1 [plasma membrane]
(Mus musculus)
Tsc1 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
XP_011517281.1
,
NP_000359.1
,
XP_016870585.1
,
XP_006717334.1
,
XP_016870586.1
,
XP_005272268.1
,
NP_001155898.1
,
NP_001155899.1
OpenTargets
ENSG00000165699
ENSEMBL
ENSP00000495533
,
ENSP00000495158
,
ENSP00000495830
,
ENST00000643072
,
ENSP00000496263
,
ENSP00000496691
,
ENST00000646625
,
ENST00000643875
,
ENSP00000298552
,
ENST00000490179
,
ENST00000646440
,
ENST00000298552
HPA
ENSG00000165699-TSC1
PRO
Q92574
Pharos - Targets
Q92574
Orphanet
TSC1
GlyGen
Q92574
PDB
7DL2
,
4Z6Y
,
5EJC
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49815 TSC2
4
p-S939,S1130,T1462-TSC2 [cytosol]
(R-HSA-165164)
p-S939,T1462-TSC2 [cytosol]
(R-HSA-199484)
TSC2 [cytosol]
(R-HSA-2980548)
p-S1387-TSC2 [cytosol]
(R-HSA-3132769)
0.935
13
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.851
6
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.725
4
UniProt:Q9P0N9 TBC1D7
1
TBC1D7 [cytosol]
(R-HSA-8854154)
0.71
5
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.669
3
UniProt:P02794 FTH1
5
FTH1 [cytosol]
(R-HSA-434212)
FTH1 [tertiary granule lumen]
(R-HSA-6801508)
FTH1 [extracellular region]
(R-HSA-2187212)
FTH1 [ficolin-1-rich granule lumen]
(R-HSA-6801531)
FTH1 [endocytic vesicle lumen]
(R-HSA-2299670)
0.635
3
UniProt:O14920 IKBKB
3
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
0.611
3
UniProt:Q00994 BEX3
1
NGFRAP1 [cytosol]
(R-HSA-194333)
0.543
5
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.527
2
UniProt:Q674X7 KAZN
1
KAZN [cytosol]
(R-HSA-6814378)
0.508
2
UniProt:Q92844 TANK
2
K63polyUb-TANK [cytosol]
(R-HSA-5362480)
TANK [cytosol]
(R-HSA-933407)
0.508
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.508
2
UniProt:Q16539 MAPK14
7
MAPK14 [ficolin-1-rich granule lumen]
(R-HSA-6803280)
MAPK14 [extracellular region]
(R-HSA-6806453)
MAPK14 [secretory granule lumen]
(R-HSA-6803300)
MAPK14 [nucleoplasm]
(R-HSA-446223)
MAPK14 [cytosol]
(R-HSA-428933)
p-T180,Y182-MAPK14 [cytosol]
(R-HSA-428935)
p-T180,Y182-MAPK14 [nucleoplasm]
(R-HSA-446227)
0.508
2
UniProt:Q9NP31 SH2D2A
1
SH2D2A [cytosol]
(R-HSA-4420125)
0.488
2
UniProt:Q96JZ2 HSH2D
0.488
2
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