Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol]
Stable Identifier
R-HSA-5607649
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
K63polyUb-34,158-p-T178,184,187,S192-MAP3K7
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
K63polyUb-TAK1 autophosphorylates (Homo sapiens)
p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-p3Y,1S-TAK1 [plasma membrane] (Homo sapiens)
TAB1:TAB2,TAB3:K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (Homo sapiens)
K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (Homo sapiens)
K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Homo sapiens)
K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (Homo sapiens)
p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-p3Y,1S-TAK1 [plasma membrane] (Homo sapiens)
TAB1:TAB2,TAB3:K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (Homo sapiens)
K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43318 MAP3K7
Gene Names
MAP3K7, TAK1
Chain
chain:1-606
Reference Genes
BioGPS Gene:6885 MAP3K7
COSMIC (genes):MAP3K7 MAP3K7
CTD Gene:6885 MAP3K7
dbSNP Gene:6885 MAP3K7
ENSEMBL:ENSG00000135341 MAP3K7
HGNC:6859 MAP3K7
KEGG Gene (Homo sapiens):6885 MAP3K7
Monarch:6885 MAP3K7
NCBI Gene:6885 MAP3K7
OMIM:602614 MAP3K7
UCSC:O43318 MAP3K7
Reference Transcript
RefSeq:NM_145331.2 MAP3K7
RefSeq:NM_003188.3 MAP3K7
RefSeq:NM_145333.2 MAP3K7
RefSeq:NM_145332.2 MAP3K7
Other Identifiers
0002760338
11736829_a_at
11736830_s_at
11741475_a_at
11741476_x_at
11742225_a_at
11743919_a_at
11750993_x_at
17021754
206853_PM_s_at
206853_s_at
206854_PM_s_at
206854_s_at
211536_PM_x_at
211536_x_at
211537_PM_x_at
211537_x_at
2964772
2964773
2964774
2964775
2964776
2964777
2964778
2964779
2964780
2964782
2964783
2964784
2964786
2964790
2964799
2964802
2964804
2964805
2964807
2964808
2964809
2964811
2964812
2964813
2964814
2964819
2964820
2964821
2964822
36905_at
53270_s_at
6885
8128260
86022_at
A_23_P500773
GE56544
GE80617
GO:0000165
GO:0000166
GO:0000287
GO:0002223
GO:0002376
GO:0002726
GO:0002753
GO:0002755
GO:0003674
GO:0004672
GO:0004674
GO:0004707
GO:0004709
GO:0004712
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005829
GO:0005886
GO:0006464
GO:0006468
GO:0006914
GO:0006915
GO:0006950
GO:0007165
GO:0007179
GO:0007249
GO:0007250
GO:0007252
GO:0007254
GO:0008150
GO:0008219
GO:0008349
GO:0008385
GO:0009056
GO:0009058
GO:0010008
GO:0016020
GO:0016239
GO:0016301
GO:0016310
GO:0016740
GO:0019899
GO:0030971
GO:0031410
GO:0032743
GO:0032991
GO:0034641
GO:0038066
GO:0038095
GO:0042802
GO:0043123
GO:0043167
GO:0043226
GO:0043276
GO:0043410
GO:0043507
GO:0043966
GO:0046872
GO:0050852
GO:0051092
GO:0051276
GO:0051403
GO:0070423
GO:0070498
GO:0097110
GO:0106310
GO:0140672
HMNXSV003034824
Hs.7510.0.S2_3p_a_at
ILMN_1810176
ILMN_2379326
PH_hs_0028131
PH_hs_0035759
TC06001948.hg
g4507360_3p_a_at
g8978251_3p_a_at
Participates
as a component of
TAB1:TAB2,TAB3:K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (Homo sapiens)
Other forms of this molecule
PolyUb-MAP3K7 [cytosol]
MAP3K7 [plasma membrane]
K63polyUb-34,158-TAK1 [cytosol]
p-MAP3K7 [cytosol]
p-T187-MAP3K7 [cytosol]
MAP3K7 [endosome membrane]
p-T184,T187-MAP3K7 [endosome membrane]
MAP3K7 [cytosol]
p-T184,T187-MAP3K7 [cytosol]
Inferred To
phospho-Map3k7 [cytosol]
(Mus musculus)
phospho-Map3k7 [cytosol]
(Rattus norvegicus)
phospho-map3k7 [cytosol]
(Danio rerio)
phospho-MAP3K7 [cytosol]
(Bos taurus)
phospho-MAP3K7 [cytosol]
(Canis familiaris)
phospho-MAP3K7 [cytosol]
(Gallus gallus)
phospho-MAP3K7 [cytosol]
(Sus scrofa)
Modified Residues
Name
ubiquitinylated lysine (K63polyUb [cytosol]) at 34
Coordinate
34
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K63polyUb [cytosol]) at 158
Coordinate
158
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
O-phospho-L-threonine at 178
Coordinate
178
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 184
Coordinate
184
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 187
Coordinate
187
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 192
Coordinate
192
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_663306.1
,
NP_663304.1
,
NP_003179.1
,
NP_663305.1
ZINC - World Drugs
M3K7_HUMAN
Guide to Pharmacology - Targets
2082
OpenTargets
ENSG00000135341
ZINC - FDA approved
M3K7_HUMAN
ZINC - Substances
M3K7_HUMAN
ZINC - Biogenic
M3K7_HUMAN
ZINC target
O43318
PRO
O43318
PDB
5V5N
,
5JGA
,
7NTH
,
5J9L
,
4GS6
,
5J7S
,
7NTI
,
4L53
,
5JK3
,
5JGD
,
4L3P
,
5GJD
,
5E7R
,
5J8I
,
2EVA
,
5JH6
,
4O91
,
5GJG
,
5GJF
,
5JGB
,
4L52
,
2YIY
ZINC - Investigational
M3K7_HUMAN
IntEnz
2.7.11.25
HPA
ENSG00000135341-MAP3K7
GeneCards
O43318
Ensembl
ENST00000369332
,
ENSP00000358335
,
ENST00000369329
,
ENST00000369327
,
ENSP00000358333
,
ENST00000369325
,
ENSP00000358331
,
ENSP00000358338
,
ENSG00000135341
Pharos - Targets
O43318
Orphanet
24131
ZINC - Predictions - Purchasable
M3K7_HUMAN
HMDB Protein
HMDBP01334
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NYJ8 TAB2
4
TAB2 [cytosol]
(R-HSA-168117)
TAB2 [endosome membrane]
(R-HSA-450279)
TAB2 [plasma membrane]
(R-HSA-168116)
TAB2 [nucleoplasm]
(R-HSA-1253323)
0.877
7
UniProt:Q15750 TAB1
6
TAB1(445-504) [cytosol]
(R-HSA-9729691)
TAB1(133-504) [cytosol]
(R-HSA-9729724)
TAB1(1-132) [cytosol]
(R-HSA-9729698)
TAB1(1-444) [cytosol]
(R-HSA-9729751)
TAB1 [endosome membrane]
(R-HSA-450238)
TAB1 [cytosol]
(R-HSA-167923)
0.823
6
UniProt:Q9UQF2 JIP1
0.723
11
UniProt:Q8N5C8 TAB3
3
TAB3 [plasma membrane]
(R-HSA-446879)
TAB3 [endosome membrane]
(R-HSA-450247)
TAB3 [cytosol]
(R-HSA-450264)
0.708
4
UniProt:O14733 MAP2K7
4
MAP2K7(?-419) [cytosol]
(R-HSA-5211401)
MAP2K7(2-?) [cytosol]
(R-HSA-5211389)
MAP2K7 [cytosol]
(R-HSA-450276)
p-S271,T275-MAP2K7 [cytosol]
(R-HSA-450353)
0.674
3
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [endosome membrane]
(R-HSA-450272)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
0.669
3
UniProt:O14920 IKBKB
3
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
0.657
6
UniProt:P0CG48 UBC
20
UBC(381-456) [endocytic vesicle membrane]
(R-HSA-939218)
UBC(533-608) [endocytic vesicle membrane]
(R-HSA-939220)
UBC(609-684) [endocytic vesicle membrane]
(R-HSA-939223)
UBC(457-532) [endocytic vesicle membrane]
(R-HSA-939195)
UBC(153-228) [endocytic vesicle membrane]
(R-HSA-939194)
UBC(305-380) [endocytic vesicle membrane]
(R-HSA-939228)
UBC(229-304) [endocytic vesicle membrane]
(R-HSA-939177)
UBC(77-152) [endocytic vesicle membrane]
(R-HSA-939210)
UBC(1-76) [endocytic vesicle membrane]
(R-HSA-939245)
Ub-566-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783166)
Ub-338-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783121)
Ub-186-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783154)
Ub-262-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783028)
Ub-414-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783061)
Ub-110-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783158)
Ub-642-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783182)
Ub-33-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783073)
Ub-488-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783078)
Ub-291-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783193)
Ub-595-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783130)
0.656
4
UniProt:O15111 CHUK
3
CHUK [cytosol]
(R-HSA-168104)
p-S176,S180-CHUK [cytosol]
(R-HSA-177667)
p-T23-CHUK [cytosol]
(R-HSA-198615)
0.65
3
UniProt:B5Z6S0 B5Z6S0
0.602
4
UniProt:O00743 PPP6C
2
PPP6C [cytosol]
(R-HSA-5685719)
PPP6C [nucleoplasm]
(R-HSA-9686576)
0.602
4
UniProt:Q9UBE8 NLK
3
NLK [cytosol]
(R-HSA-4411330)
p-T298-NLK [cytosol]
(R-HSA-4411398)
p-T298-NLK [nucleoplasm]
(R-HSA-4411376)
0.569
3
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.564
2
UniProt:P40763 STAT3
12
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
p-STAT3 [cytosol]
(R-HSA-8982823)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
0.558
4
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [cytosol]
(R-COV-9694300)
p-S188,206-N [cytosol]
(R-COV-9729324)
p-8S-N [cytosol]
(R-COV-9729335)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
0.556
4
UniProt:Q9UKE5 TNIK
1
TNIK [cytosol]
(R-HSA-3214889)
0.499
3
UniProt:P15311 EZR
3
p-Y146,Y354-EZR [cytosol]
(R-HSA-374572)
p-T567-EZR [cytosol]
(R-HSA-374559)
EZR [cytosol]
(R-HSA-9020826)
0.483
2
© 2022
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text