Reactome | K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol]

K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol]

Stable Identifier

R-HSA-5607649

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

K63polyUb-34,158-p-T178,184,187,S192-MAP3K7

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External Reference Information

External Reference

UniProt:O43318 MAP3K7

Gene Names

MAP3K7, TAK1

Chain

chain:1-606

Reference Genes

BioGPS Gene:6885 MAP3K7

COSMIC (genes):MAP3K7 MAP3K7

CTD Gene:6885 MAP3K7

dbSNP Gene:6885 MAP3K7

ENSEMBL:ENSG00000135341 MAP3K7

ENSEMBL:ENSG00000135341.19 MAP3K7

HGNC:6859 MAP3K7

KEGG Gene (Homo sapiens):6885 MAP3K7

Monarch:6885 MAP3K7

NCBI Gene:6885 MAP3K7

OMIM:602614 MAP3K7

UCSC:O43318 MAP3K7

Reference Transcript

Other Identifiers

11736829_a_at

11736830_s_at

11741475_a_at

11741476_x_at

11742225_a_at

11743919_a_at

11750993_x_at

17021754

206853_PM_s_at

206853_s_at

206854_PM_s_at

206854_s_at

211536_PM_x_at

211536_x_at

211537_PM_x_at

211537_x_at

2964772

2964773

2964774

2964775

2964776

2964777

2964778

2964779

2964780

2964782

2964783

2964784

2964786

2964790

2964799

2964802

2964804

2964805

2964807

2964808

2964809

2964811

2964812

2964813

2964814

2964819

2964820

2964821

2964822

36905_at

53270_s_at

6885

8128260

86022_at

A_23_P500773

GE56544

GE80617

GO:0000165

GO:0000166

GO:0000287

GO:0001223

GO:0001666

GO:0002223

GO:0002376

GO:0002726

GO:0002753

GO:0002755

GO:0003824

GO:0004672

GO:0004674

GO:0004707

GO:0004709

GO:0005114

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006468

GO:0006914

GO:0006915

GO:0006954

GO:0007165

GO:0007179

GO:0007249

GO:0007250

GO:0007252

GO:0007254

GO:0008349

GO:0008385

GO:0010008

GO:0010508

GO:0010629

GO:0012501

GO:0016020

GO:0016239

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0030971

GO:0031410

GO:0031625

GO:0032743

GO:0035173

GO:0036211

GO:0038066

GO:0038095

GO:0038173

GO:0042802

GO:0043123

GO:0043226

GO:0043276

GO:0043410

GO:0043507

GO:0043966

GO:0045787

GO:0045793

GO:0046872

GO:0048870

GO:0050852

GO:0050896

GO:0051092

GO:0051403

GO:0055085

GO:0070423

GO:0070498

GO:0071356

GO:0071560

GO:0090650

GO:0097110

GO:0098542

GO:0106310

GO:0120283

GO:0140096

GO:0140297

GO:0140672

GO:1901386

GO:1904385

GO:1904707

GO:1904754

GO:1990450

GO:1990776

HMNXSV003034824

Hs.7510.0.S2_3p_a_at

ILMN_1810176

ILMN_2379326

PH_hs_0028131

PH_hs_0035759

TC06001948.hg

g4507360_3p_a_at

g8978251_3p_a_at

Participates

as a component of

TAB1:TAB2,TAB3:K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (Homo sapiens)

Other forms of this molecule

PolyUb-MAP3K7 [cytosol]

MAP3K7 [plasma membrane]

p-T187-MAP3K7 [cytosol]

K63polyUb-34,158-TAK1 [cytosol]

p-MAP3K7 [cytosol]

MAP3K7 [endosome membrane]

p-T184,T187-MAP3K7 [endosome membrane]

MAP3K7 [cytosol]

p-T184,T187-MAP3K7 [cytosol]

Inferred To

phospho-K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (Bos taurus)

phospho-K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (Canis familiaris)

phospho-K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (Danio rerio)

phospho-K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (Gallus gallus)

phospho-K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (Mus musculus)

phospho-K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (Rattus norvegicus)

phospho-K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (Sus scrofa)

Modified Residues

Name

ubiquitinylated lysine (K63polyUb [cytosol]) at 34

Coordinate

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Name

ubiquitinylated lysine (K63polyUb [cytosol]) at 158

Coordinate

158

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Name

O-phospho-L-threonine at 178

Coordinate

178

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at 184

Coordinate

184

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at 187

Coordinate

187

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 192

Coordinate

192

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_003179.1, NP_663306.1, NP_663305.1, NP_663304.1

ZINC - World Drugs

M3K7_HUMAN

Guide to Pharmacology - Targets

2082

OpenTargets

ENSG00000135341

ZINC - FDA approved

M3K7_HUMAN

ZINC - Substances

M3K7_HUMAN

ZINC target

O43318

ZINC - Biogenic

M3K7_HUMAN

PRO

O43318

PDB

5GJD, 5V5N, 2YIY, 7NTI, 2EVA, 7NTH, 4O91, 4L53, 5E7R, 5JGD, 5J9L, 4L52, 5J7S, 5J8I, 5GJG, 5JH6, 5JGB, 5JGA, 5GJF, 4GS6, 4L3P, 5JK3

ZINC - Investigational

M3K7_HUMAN

HPA

ENSG00000135341-MAP3K7

GeneCards

O43318

Ensembl

ENSP00000515074, ENSP00000358331, ENSP00000358333, ENSG00000135341, ENSP00000358335, ENST00000369325, ENST00000369332, ENST00000369327, ENSP00000358338, ENST00000700580, ENST00000369329

Pharos - Targets

O43318

Orphanet

24131

ZINC - Predictions - Purchasable

M3K7_HUMAN

HMDB Protein

HMDBP01334

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NYJ8 TAB2	4	TAB2 [cytosol] (R-HSA-168117) TAB2 [endosome membrane] (R-HSA-450279) TAB2 [plasma membrane] (R-HSA-168116) TAB2 [nucleoplasm] (R-HSA-1253323)	0.877	7
UniProt:Q15750 TAB1	6	TAB1(445-504) [cytosol] (R-HSA-9729691) TAB1(133-504) [cytosol] (R-HSA-9729724) TAB1(1-132) [cytosol] (R-HSA-9729698) TAB1(1-444) [cytosol] (R-HSA-9729751) TAB1 [endosome membrane] (R-HSA-450238) TAB1 [cytosol] (R-HSA-167923)	0.823	6
UniProt:Q9UQF2 JIP1			0.723	11
UniProt:Q8N5C8 TAB3	3	TAB3 [plasma membrane] (R-HSA-446879) TAB3 [endosome membrane] (R-HSA-450247) TAB3 [cytosol] (R-HSA-450264)	0.708	4
UniProt:O14733 MAP2K7	4	MAP2K7(?-419) [cytosol] (R-HSA-5211401) MAP2K7(2-?) [cytosol] (R-HSA-5211389) MAP2K7 [cytosol] (R-HSA-450276) p-S271,T275-MAP2K7 [cytosol] (R-HSA-450353)	0.674	3
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955)	0.669	3
UniProt:O14920 IKBKB	3	IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518) IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506)	0.657	6
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.656	4
UniProt:O15111 CHUK	3	CHUK [cytosol] (R-HSA-168104) p-S176,S180-CHUK [cytosol] (R-HSA-177667) p-T23-CHUK [cytosol] (R-HSA-198615)	0.65	3
UniProt:B5Z6S0 B5Z6S0			0.602	4
UniProt:O00743 PPP6C	2	PPP6C [cytosol] (R-HSA-5685719) PPP6C [nucleoplasm] (R-HSA-9686576)	0.602	4
UniProt:Q9UBE8 NLK	3	NLK [cytosol] (R-HSA-4411330) p-T298-NLK [cytosol] (R-HSA-4411398) p-T298-NLK [nucleoplasm] (R-HSA-4411376)	0.569	3
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.564	2
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.558	4
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.556	4
UniProt:Q9UKE5 TNIK	1	TNIK [cytosol] (R-HSA-3214889)	0.499	3
UniProt:P15311 EZR	3	p-Y146,Y354-EZR [cytosol] (R-HSA-374572) p-T567-EZR [cytosol] (R-HSA-374559) EZR [cytosol] (R-HSA-9020826)	0.483	2

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