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WWTR1 [nucleoplasm]
Stable Identifier
R-HSA-1629775
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
WW domain-containing transcription regulator protein 1, Transcriptional coactivator with PDZ-binding motif, TAZ
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
EGR2 and SOX10-mediated initiation of Schwann cell myelination (Homo sapiens)
EGR2, SOX10 and TEAD1 bind enhancers in the PMP22 gene (Homo sapiens)
PMP22 gene:EGR2:SOX10:TEAD1:WWTR1,YAP1 [nucleoplasm] (Homo sapiens)
TEAD1:WWTR1,YAP1 [nucleoplasm] (Homo sapiens)
TEAD1:WWTR1 [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
TEAD1:WWTR1,YAP1 [nucleoplasm] (Homo sapiens)
TEAD1:WWTR1 [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
PMP22 gene expression (Homo sapiens)
PMP22 gene:EGR2:SOX10:TEAD1:WWTR1,YAP1 [nucleoplasm] (Homo sapiens)
TEAD1:WWTR1,YAP1 [nucleoplasm] (Homo sapiens)
TEAD1:WWTR1 [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
WWTR1:SMAD stimulates transcription of SMAD7 (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4:SMAD7 gene [nucleoplasm] (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 binds SMAD7 gene promoter (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4:SMAD7 gene [nucleoplasm] (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4:SERPINE1 gene [nucleoplasm] (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
WWTR1:SMAD translocates to the nucleus (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 binds SERPINE1 gene promoter (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4:SERPINE1 gene [nucleoplasm] (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
RUNX2 regulates bone development (Homo sapiens)
RUNX2 regulates osteoblast differentiation (Homo sapiens)
BGLAP gene expression is stimulated by RUNX2, WWTR1 and RB1 and inhibited by AR, YAP1 and ZNF521 (Homo sapiens)
RUNX2:WWTR1(TAZ) [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
RUNX2:WWTR1:BGLAP gene [nucleoplasm] (Homo sapiens)
RUNX2:WWTR1(TAZ) [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
The complex of RUNX2 and WWTR1 (TAZ) binds the BGLAP gene promoter (Homo sapiens)
RUNX2:WWTR1(TAZ) [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
RUNX2:WWTR1:BGLAP gene [nucleoplasm] (Homo sapiens)
RUNX2:WWTR1(TAZ) [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
WWTR1 (TAZ) binds RUNX2 (Homo sapiens)
RUNX2:WWTR1(TAZ) [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
RUNX3 regulates YAP1-mediated transcription (Homo sapiens)
Expression of CTGF (Homo sapiens)
TEAD:WWTR1(TAZ) [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
YAP1- and WWTR1 (TAZ)-stimulated gene expression (Homo sapiens)
Expression of CTGF (Homo sapiens)
TEAD:WWTR1(TAZ) [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
Expression of NPPA (ANF) (Homo sapiens)
TBX5:WWTR1:PCAF [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
WWTR1 (TAZ) binds RUNX2 (Homo sapiens)
RUNX2:WWTR1(TAZ) [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
WWTR1 (TAZ) binds TEAD (Homo sapiens)
TEAD:WWTR1(TAZ) [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
WWTR1 (TAZ), TBX5, and PCAF form a complex (Homo sapiens)
TBX5:WWTR1:PCAF [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Physiological factors (Homo sapiens)
Expression of NPPA (ANF) (Homo sapiens)
TBX5:WWTR1:PCAF [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hippo (Homo sapiens)
Translocation of WWTR1 (TAZ) to the nucleus (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
WWTR1:SMAD stimulates transcription of SMAD7 (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4:SMAD7 gene [nucleoplasm] (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 binds SMAD7 gene promoter (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4:SMAD7 gene [nucleoplasm] (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4:SERPINE1 gene [nucleoplasm] (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
WWTR1:SMAD translocates to the nucleus (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 binds SERPINE1 gene promoter (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4:SERPINE1 gene [nucleoplasm] (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
WWTR1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9GZV5 WWTR1
Gene Names
WWTR1, TAZ
Chain
chain:1-400
Reference Genes
BioGPS Gene:25937 WWTR1
COSMIC (genes):WWTR1 WWTR1
CTD Gene:25937 WWTR1
dbSNP Gene:25937 WWTR1
ENSEMBL:ENSG00000018408.15 WWTR1
HGNC:24042 WWTR1
KEGG Gene (Homo sapiens):25937 WWTR1
Monarch:25937 WWTR1
NCBI Gene:25937 WWTR1
OMIM:607392 WWTR1
UCSC:Q9GZV5 WWTR1
Reference Transcript
RefSeq:NM_001348362.1 WWTR1
RefSeq:NM_001168278.2 WWTR1
RefSeq:XM_017006122.1 WWTR1
RefSeq:NM_015472.5 WWTR1
RefSeq:NM_001168280.2 WWTR1
Other Identifiers
11755099_a_at
11759482_at
11759483_at
202132_PM_at
202132_at
202133_PM_at
202133_at
202134_PM_s_at
202134_s_at
25937
2700407
2700408
2700409
2700410
2700411
2700412
2700413
2700414
2700415
2700417
2700418
2700425
2700433
2700461
2700463
2700464
2700471
33876_at
8091422
A_23_P29769
A_24_P944383
A_24_P944390
A_32_P6868
GE56247
GE82008
GO:0000122
GO:0001649
GO:0001894
GO:0001933
GO:0003013
GO:0003015
GO:0003713
GO:0003714
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005737
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006469
GO:0008284
GO:0010718
GO:0016020
GO:0016567
GO:0016604
GO:0017145
GO:0023052
GO:0030154
GO:0030163
GO:0031146
GO:0032835
GO:0035264
GO:0035329
GO:0036211
GO:0042803
GO:0043226
GO:0044782
GO:0045599
GO:0045669
GO:0045944
GO:0048762
GO:0048856
GO:0060271
GO:0060390
GO:0060828
GO:0060993
GO:0072307
GO:0090090
GO:0140110
GO:1900182
HMNXSV003013267
Hs.24341.0.A2_3p_at
Hs.24341.0.A3_3p_at
ILMN_1787115
PH_hs_0002143
g13346497_3p_a_at
Participates
as an input of
WWTR1 (TAZ) binds RUNX2 (Homo sapiens)
WWTR1 (TAZ), TBX5, and PCAF form a complex (Homo sapiens)
WWTR1 (TAZ) binds TEAD (Homo sapiens)
as a component of
RUNX2:WWTR1(TAZ) [nucleoplasm] (Homo sapiens)
TBX5:WWTR1:PCAF [nucleoplasm] (Homo sapiens)
TEAD:WWTR1(TAZ) [nucleoplasm] (Homo sapiens)
TEAD1:WWTR1 [nucleoplasm] (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
as an output of
Translocation of WWTR1 (TAZ) to the nucleus (Homo sapiens)
Other forms of this molecule
p-S89-WWTR1 [cytosol]
WWTR1 [cytosol]
Inferred To
WWTR1 [nucleoplasm]
(Bos taurus)
WWTR1 [nucleoplasm]
(Canis familiaris)
WWTR1 [nucleoplasm]
(Danio rerio)
WWTR1 [nucleoplasm]
(Gallus gallus)
WWTR1 [nucleoplasm]
(Sus scrofa)
mblac1 [nucleoplasm]
(Xenopus tropicalis)
yap-1 [nucleoplasm]
(Caenorhabditis elegans)
yki [nucleoplasm]
(Drosophila melanogaster)
Wwtr1 [nucleoplasm]
(Mus musculus)
Wwtr1 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_001161752.1
,
XP_016861611.1
,
NP_001161750.1
,
NP_001335291.1
,
NP_056287.1
OpenTargets
ENSG00000018408
GeneCards
Q9GZV5
HPA
ENSG00000018408-WWTR1
Ensembl
ENSG00000018408
,
ENST00000465804
,
ENSP00000419465
,
ENST00000467467
,
ENSP00000353847
,
ENST00000360632
,
ENSP00000419234
PRO
Q9GZV5
Pharos - Targets
Q9GZV5
Orphanet
23229
PDB
5N5W
,
6RP6
,
6SLX
,
6RJQ
,
5N75
,
6SLW
,
6RJL
,
5N5R
,
6RHC
,
5N5T
Interactors (23)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15561 TEAD4
1
TEAD4 [nucleoplasm]
(R-HSA-2032780)
0.851
9
UniProt:Q99594 TEAD3
1
TEAD3 [nucleoplasm]
(R-HSA-2032767)
0.667
3
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.659
3
UniProt:O95835 LATS1
2
LATS1 [cytosol]
(R-HSA-2028562)
p-S909,T1079-LATS1 [cytosol]
(R-HSA-2028551)
0.641
5
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.641
4
UniProt:Q969T9 WBP2
0.61
6
UniProt:Q9BZD6 TMG4
0.602
4
UniProt:O14641 DVL2
5
pp-DVL2 [cytosol]
(R-HSA-3772398)
p-DVL2 [cytosol]
(R-HSA-201706)
p-DVL2 [clathrin-coated endocytic vesicle]
(R-HSA-5138444)
DVL2 [cytosol]
(R-HSA-201694)
ub-DVL2 [cytosol]
(R-HSA-4652689)
0.591
4
UniProt:Q14160 SCRIB
1
SCRIB [cytosol]
(R-HSA-4608858)
0.59
3
UniProt:P62262 1433E
0.571
3
UniProt:Q9NUJ3 T11L1
0.556
3
UniProt:Q8WWV3 RT4I1
0.556
3
UniProt:Q96LT6 CA074
0.556
3
UniProt:P28347-2 TEAD1
0.556
3
UniProt:Q15562-2 TEAD2
0.556
3
UniProt:Q14005-2 Q140052
0.556
3
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.547
2
UniProt:Q01196 RUNX1
5
RUNX1 [plasma membrane]
(R-HSA-5667138)
p-S249,S273,S276-RUNX1 [nucleoplasm]
(R-HSA-8878063)
MeR206,MeR210-RUNX1 [nucleoplasm]
(R-HSA-8934750)
p-7Y-RUNX1 [nucleoplasm]
(R-HSA-8937712)
RUNX1 [nucleoplasm]
(R-HSA-8865295)
0.527
2
UniProt:Q15562 TEAD2
1
TEAD2 [nucleoplasm]
(R-HSA-2032763)
0.527
2
UniProt:O14640 DVL1
4
pp-DVL1 [cytosol]
(R-HSA-3772396)
p-S-DVL1 [cytosol]
(R-HSA-201700)
DVL1 [cytosol]
(R-HSA-201687)
ub-DVL1 [cytosol]
(R-HSA-4641157)
0.524
2
UniProt:P78371 CCT2
3
CCT2 [azurophil granule lumen]
(R-HSA-6799356)
CCT2 [extracellular region]
(R-HSA-6806220)
CCT2 [cytosol]
(R-HSA-390464)
0.499
2
UniProt:Q15599 NHRF2
0.463
2
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