Reactome | WWTR1 [nucleoplasm]

WWTR1 [nucleoplasm]

Stable Identifier

R-HSA-1629775

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

WW domain-containing transcription regulator protein 1, Transcriptional coactivator with PDZ-binding motif, TAZ

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9GZV5 WWTR1

Gene Names

WWTR1, TAZ

Chain

chain:1-400

Reference Genes

BioGPS Gene:25937 WWTR1

COSMIC (genes):TAZ TAFAZZIN

COSMIC (genes):WWTR1 WWTR1

CTD Gene:25937 WWTR1

dbSNP Gene:25937 WWTR1

ENSEMBL:ENSG00000018408 WWTR1

HGNC:24042 WWTR1

KEGG:hsa:25937 WWTR1

Monarch:25937 WWTR1

NCBI Gene:25937 WWTR1

OMIM:607392 WWTR1

UCSC:Q9GZV5 WWTR1

Reference Transcript

Other Identifiers

11755099_a_at

11759482_at

11759483_at

202132_PM_at

202132_at

202133_PM_at

202133_at

202134_PM_s_at

202134_s_at

25937

2667757

2700407

2700408

2700409

2700410

2700411

2700412

2700413

2700414

2700415

2700417

2700418

2700425

2700431

2700432

2700433

2700437

2700459

2700460

2700461

2700462

2700463

2700464

2700470

2700471

2700473

2700474

2700477

2700479

2700480

33876_at

8091422

A_23_P29769

A_24_P944383

A_24_P944390

A_32_P6868

A_33_P3605352

GE56247

GE82008

GO:0000122

GO:0001649

GO:0001894

GO:0001933

GO:0003013

GO:0003015

GO:0003712

GO:0003713

GO:0003714

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005737

GO:0005829

GO:0005886

GO:0006355

GO:0006469

GO:0008284

GO:0010718

GO:0016567

GO:0016604

GO:0017145

GO:0030154

GO:0030163

GO:0031146

GO:0032835

GO:0035264

GO:0035329

GO:0042803

GO:0043226

GO:0044782

GO:0045599

GO:0045669

GO:0045944

GO:0048762

GO:0048856

GO:0060090

GO:0060271

GO:0060395

GO:0060828

GO:0060993

GO:0072307

GO:0090090

GO:0140110

GO:1900182

HMNXSV003013267

HMNXSV003057122

Hs.24341.0.A2_3p_at

Hs.24341.0.A3_3p_at

ILMN_1787115

PH_hs_0002143

PH_hs_0035163

g13346497_3p_a_at

Participates

as a component of

as an input of

as an output of

Translocation of WWTR1 (TAZ) to the nucleus (Homo sapiens)

Other forms of this molecule

WWTR1 [cytosol]

p-S89-WWTR1 [cytosol]

Inferred To

WWTR1 [nucleoplasm] (Bos taurus)

WWTR1 [nucleoplasm] (Canis familiaris)

WWTR1 [nucleoplasm] (Gallus gallus)

WWTR1 [nucleoplasm] (Sus scrofa)

wwtr1 [nucleoplasm] (Danio rerio)

wwtr1 [nucleoplasm] (Xenopus tropicalis)

Ghost homologue of WWTR1 [nucleoplasm] (Drosophila melanogaster)

yap-1 [nucleoplasm] (Caenorhabditis elegans)

Wwtr1 [nucleoplasm] (Mus musculus)

Wwtr1 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_056287.1, NP_001161752.1, XP_016861611.1, NP_001335291.1, NP_001161750.1

OpenTargets

ENSG00000018408

ENSEMBL

ENSP00000419234, ENSP00000419465, ENST00000360632, ENST00000467467, ENSG00000018408, ENST00000465804, ENSP00000353847

HPA

ENSG00000018408-WWTR1

GeneCards

WWTR1

PRO

Q9GZV5

Pharos - Targets

Q9GZV5

Orphanet

WWTR1

PDB

6RJL, 6RP6, 5N75, 5N5W, 5N5R, 6RHC, 6RJQ, 5N5T, 8R0Z, 6SLX, 6SLW

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15561 TEAD4	1	TEAD4 [nucleoplasm] (R-HSA-2032780)	0.888	11
UniProt:Q99594 TEAD3	1	TEAD3 [nucleoplasm] (R-HSA-2032767)	0.745	5
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.738	4
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.738	5
UniProt:Q15562 TEAD2	1	TEAD2 [nucleoplasm] (R-HSA-2032763)	0.643	5
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.643	3
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.643	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.641	4
UniProt:O95835 LATS1	2	LATS1 [cytosol] (R-HSA-2028562) p-S909,T1079-LATS1 [cytosol] (R-HSA-2028551)	0.641	5
UniProt:Q969T9 WBP2			0.61	6
UniProt:Q15599 NHRF2			0.602	3
UniProt:Q9BZD6 TMG4			0.602	4
UniProt:O14641 DVL2	5	pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) DVL2 [cytosol] (R-HSA-201694) ub-DVL2 [cytosol] (R-HSA-4652689)	0.591	4
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.59	3
UniProt:P62262 1433E			0.571	3
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.564	2
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q15562-2 TEAD2			0.556	3
UniProt:P28347-2 TEAD1			0.556	3
UniProt:Q9NUJ3 T11L1			0.556	3
UniProt:Q14005-2 IL16			0.556	3
UniProt:Q96LT6 CA074			0.556	3
UniProt:Q8WWV3 RT4I1			0.556	3
UniProt:P28347 TEAD1	1	TEAD1 [nucleoplasm] (R-HSA-2032774)	0.527	3
UniProt:Q01196 RUNX1	5	RUNX1 [nucleoplasm] (R-HSA-8865295) MeR206,MeR210-RUNX1 [nucleoplasm] (R-HSA-8934750) p-7Y-RUNX1 [nucleoplasm] (R-HSA-8937712) p-S249,T273,S276-RUNX1 [nucleoplasm] (R-HSA-8878063) RUNX1 [plasma membrane] (R-HSA-5667138)	0.527	2
UniProt:Q4VCS5 AMOT			0.527	2
UniProt:O14640 DVL1	4	pp-DVL1 [cytosol] (R-HSA-3772396) p-S-DVL1 [cytosol] (R-HSA-201700) DVL1 [cytosol] (R-HSA-201687) ub-DVL1 [cytosol] (R-HSA-4641157)	0.524	2
UniProt:P78371 CCT2	3	CCT2 [azurophil granule lumen] (R-HSA-6799356) CCT2 [extracellular region] (R-HSA-6806220) CCT2 [cytosol] (R-HSA-390464)	0.499	2

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