Reactome | WWTR1 [nucleoplasm]

WWTR1 [nucleoplasm]

Stable Identifier

R-HSA-1629775

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

WW domain-containing transcription regulator protein 1, Transcriptional coactivator with PDZ-binding motif, TAZ

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9GZV5 WWTR1

Gene Names

WWTR1, TAZ

Chain

chain:1-400

Reference Genes

BioGPS Gene:25937 WWTR1

COSMIC (genes):WWTR1 WWTR1

CTD Gene:25937 WWTR1

dbSNP Gene:25937 WWTR1

ENSEMBL:ENSG00000018408.15 WWTR1

HGNC:24042 WWTR1

KEGG Gene (Homo sapiens):25937 WWTR1

Monarch:25937 WWTR1

NCBI Gene:25937 WWTR1

OMIM:607392 WWTR1

UCSC:Q9GZV5 WWTR1

Reference Transcript

Other Identifiers

11755099_a_at

11759482_at

11759483_at

202132_PM_at

202132_at

202133_PM_at

202133_at

202134_PM_s_at

202134_s_at

25937

2700407

2700408

2700409

2700410

2700411

2700412

2700413

2700414

2700415

2700417

2700418

2700425

2700433

2700461

2700463

2700464

2700471

33876_at

8091422

A_23_P29769

A_24_P944383

A_24_P944390

A_32_P6868

GE56247

GE82008

GO:0000122

GO:0001649

GO:0001894

GO:0001933

GO:0003013

GO:0003015

GO:0003713

GO:0003714

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005737

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006469

GO:0008284

GO:0010718

GO:0016020

GO:0016567

GO:0016604

GO:0017145

GO:0023052

GO:0030154

GO:0030163

GO:0031146

GO:0032835

GO:0035264

GO:0035329

GO:0036211

GO:0042803

GO:0043226

GO:0044782

GO:0045599

GO:0045669

GO:0045944

GO:0048762

GO:0048856

GO:0060271

GO:0060390

GO:0060828

GO:0060993

GO:0072307

GO:0090090

GO:0140110

GO:1900182

HMNXSV003013267

Hs.24341.0.A2_3p_at

Hs.24341.0.A3_3p_at

ILMN_1787115

PH_hs_0002143

g13346497_3p_a_at

Participates

as an input of

as a component of

as an output of

Translocation of WWTR1 (TAZ) to the nucleus (Homo sapiens)

Other forms of this molecule

p-S89-WWTR1 [cytosol]

WWTR1 [cytosol]

Inferred To

WWTR1 [nucleoplasm] (Bos taurus)

WWTR1 [nucleoplasm] (Canis familiaris)

WWTR1 [nucleoplasm] (Danio rerio)

WWTR1 [nucleoplasm] (Gallus gallus)

WWTR1 [nucleoplasm] (Sus scrofa)

mblac1 [nucleoplasm] (Xenopus tropicalis)

yap-1 [nucleoplasm] (Caenorhabditis elegans)

yki [nucleoplasm] (Drosophila melanogaster)

Wwtr1 [nucleoplasm] (Mus musculus)

Wwtr1 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001161752.1, XP_016861611.1, NP_001161750.1, NP_001335291.1, NP_056287.1

OpenTargets

ENSG00000018408

GeneCards

Q9GZV5

HPA

ENSG00000018408-WWTR1

Ensembl

ENSG00000018408, ENST00000465804, ENSP00000419465, ENST00000467467, ENSP00000353847, ENST00000360632, ENSP00000419234

PRO

Q9GZV5

Pharos - Targets

Q9GZV5

Orphanet

23229

PDB

5N5W, 6RP6, 6SLX, 6RJQ, 5N75, 6SLW, 6RJL, 5N5R, 6RHC, 5N5T

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15561 TEAD4	1	TEAD4 [nucleoplasm] (R-HSA-2032780)	0.851	9
UniProt:Q99594 TEAD3	1	TEAD3 [nucleoplasm] (R-HSA-2032767)	0.667	3
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.659	3
UniProt:O95835 LATS1	2	LATS1 [cytosol] (R-HSA-2028562) p-S909,T1079-LATS1 [cytosol] (R-HSA-2028551)	0.641	5
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.641	4
UniProt:Q969T9 WBP2			0.61	6
UniProt:Q9BZD6 TMG4			0.602	4
UniProt:O14641 DVL2	5	pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) DVL2 [cytosol] (R-HSA-201694) ub-DVL2 [cytosol] (R-HSA-4652689)	0.591	4
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.59	3
UniProt:P62262 1433E			0.571	3
UniProt:Q9NUJ3 T11L1			0.556	3
UniProt:Q8WWV3 RT4I1			0.556	3
UniProt:Q96LT6 CA074			0.556	3
UniProt:P28347-2 TEAD1			0.556	3
UniProt:Q15562-2 TEAD2			0.556	3
UniProt:Q14005-2 Q140052			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.547	2
UniProt:Q01196 RUNX1	5	RUNX1 [plasma membrane] (R-HSA-5667138) p-S249,S273,S276-RUNX1 [nucleoplasm] (R-HSA-8878063) MeR206,MeR210-RUNX1 [nucleoplasm] (R-HSA-8934750) p-7Y-RUNX1 [nucleoplasm] (R-HSA-8937712) RUNX1 [nucleoplasm] (R-HSA-8865295)	0.527	2
UniProt:Q15562 TEAD2	1	TEAD2 [nucleoplasm] (R-HSA-2032763)	0.527	2
UniProt:O14640 DVL1	4	pp-DVL1 [cytosol] (R-HSA-3772396) p-S-DVL1 [cytosol] (R-HSA-201700) DVL1 [cytosol] (R-HSA-201687) ub-DVL1 [cytosol] (R-HSA-4641157)	0.524	2
UniProt:P78371 CCT2	3	CCT2 [azurophil granule lumen] (R-HSA-6799356) CCT2 [extracellular region] (R-HSA-6806220) CCT2 [cytosol] (R-HSA-390464)	0.499	2
UniProt:Q15599 NHRF2			0.463	2

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