Reactome | ARHGEF6 [cytosol]

ARHGEF6 [cytosol]

Stable Identifier

R-HSA-195017

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Alpha-Pix, PIX alpha, Cool-2

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q15052 ARHGEF6

Gene Names

ARHGEF6, COOL2, KIAA0006, PIXA

Chain

chain:1-776

Reference Genes

BioGPS Gene:9459 ARHGEF6

COSMIC (genes):ARHGEF6 ARHGEF6

CTD Gene:9459 ARHGEF6

dbSNP Gene:9459 ARHGEF6

ENSEMBL:ENSG00000129675 ARHGEF6

HGNC:685 ARHGEF6

KEGG:hsa:9459 ARHGEF6

Monarch:9459 ARHGEF6

NCBI Gene:9459 ARHGEF6

OMIM:300267 ARHGEF6

UCSC:Q15052 ARHGEF6

Reference Transcript

Other Identifiers

11723368_a_at

11752189_a_at

11752825_a_at

17114520

209539_PM_at

209539_at

37543_at

4023468

4023469

4023470

4023471

4023472

4023474

4023476

4023479

4023482

4023483

4023484

4023485

4023486

4023487

4023488

4023489

4023490

4023492

4023498

4023500

4023501

4023502

4023511

4023512

4023517

4023520

4023521

4023522

8175393

9459

A_23_P85024

A_24_P228875

D13631_s_at

D25304_at

GE57127

GO:0005085

GO:0005096

GO:0005515

GO:0005737

GO:0005829

GO:0005911

GO:0006915

GO:0007254

GO:0012501

GO:0030027

GO:0030032

GO:0042995

GO:0098772

HMNXSV003044447

Hs.79307.0.S2_3p_at

ILMN_1803423

PH_hs_0024220

TC0X001416.hg

Participates

as a candidate of

as an output of

Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Homo sapiens)

as a component of

as an input of

as a member of

GEFs [cytosol] (Homo sapiens)

Inferred To

pix-1 [cytosol] (Caenorhabditis elegans)

Arhgef6 [cytosol] (Mus musculus)

Arhgef6 [cytosol] (Rattus norvegicus)

arhgef6 [cytosol] (Xenopus tropicalis)

RtGEF [cytosol] (Drosophila melanogaster)

ARHGEF6 [cytosol] (Bos taurus)

ARHGEF6 [cytosol] (Canis familiaris)

ARHGEF6 [cytosol] (Gallus gallus)

ARHGEF6 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_004831.1, NP_001293106.1

OpenTargets

ENSG00000129675

ENSEMBL

ENSP00000250617, ENST00000250617, ENSP00000359656, ENSP00000359654, ENST00000370622, ENST00000370620

HPA

ENSG00000129675-ARHGEF6

PRO

Q15052

Pharos - Targets

Q15052

GlyGen

Q15052

Orphanet

ARHGEF6

HMDB Protein

HMDBP11457

PDB

1WYR, 1UJY

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524)	0.825	8
UniProt:Q13153 PAK1	5	p-S144,T423-PAK1 [cytosol] (R-HSA-399819) PAK1 [cytosol] (R-HSA-162629) Active PAK1 [cytosol] (R-HSA-8964622) p-S144,T423-PAK1 [plasma membrane] (R-HSA-3928472) PAK1 [plasma membrane] (R-HSA-3928409)	0.798	7
UniProt:Q15599 NHRF2			0.638	3
UniProt:Q14161-11 GIT2			0.631	9
UniProt:O60880-1 SH2D1A			0.581	3
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
IntAct:EBI-22384398 CCSB ORF ID			0.556	3
IntAct:EBI-16439879 CCSB ORF ID			0.556	3
UniProt:Q9BYV2 TRI54			0.556	3
UniProt:Q7Z3Y8 KRT27	1	KRT27 [cytosol] (R-HSA-6809587)	0.556	3
UniProt:Q8ND90 PNMA1			0.556	3
UniProt:Q9UKT9 IKZF3			0.556	3
UniProt:Q05BL1 Q05BL1			0.556	3
UniProt:P78424 PO6F2			0.556	3
IntAct:EBI-22314709 CCSB ORF ID			0.556	3
UniProt:O75031 HSF2B			0.556	3
UniProt:Q9UIY3 RWD2A			0.556	3
UniProt:Q9Y2X7 GIT1	2	GIT1 [cytosol] (R-HSA-430326) p-Y383-GIT1 [cytosol] (R-HSA-3928463)	0.547	3
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.527	5
UniProt:P63208 SKP1	2	SKP1 [cytosol] (R-HSA-174150) SKP1 [nucleoplasm] (R-HSA-187538)	0.527	3
UniProt:Q14155 ARHGEF7	1	ARHGEF7 [cytosol] (R-HSA-430346)	0.527	4
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.527	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.527	2
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.527	2
UniProt:P41227 NAA10			0.524	3