Reactome | p-S459 PTPN3 [cytosol]

p-S459 PTPN3 [cytosol]

Stable Identifier

R-HSA-8868111

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tyrosine-protein phosphatase non-receptor type 3 ecNumber3.1.3.48/ecNumber, PTN3_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - Negative regulation of MAPK pathway (Homo sapiens)
        
        MAPK12 phosphorylates PTPN3 (Homo sapiens)
        
        p-S459 PTPN3:p-T183,Y185-MAPK12 [cytosol] (Homo sapiens)
        
        p-S459 PTPN3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P26045 PTPN3

Gene Names

PTPN3, PTPH1

Chain

chain:1-913

Reference Genes

BioGPS Gene:5774 PTPN3

COSMIC (genes):PTPN3 PTPN3

CTD Gene:5774 PTPN3

dbSNP Gene:5774 PTPN3

ENSEMBL:ENSG00000070159 PTPN3

ENSEMBL_homo_sapiens_GENE:ENSG00000070159.14 PTPN3

HGNC:9655 PTPN3

KEGG Gene (Homo sapiens):5774 PTPN3

Monarch:5774 PTPN3

NCBI Gene:5774 PTPN3

OMIM:176877 PTPN3

UCSC:P26045 PTPN3

Reference Transcript

Other Identifiers

11739618_a_at

11739619_a_at

11740363_a_at

11740364_a_at

11740367_a_at

11740368_s_at

11741134_a_at

1458_at

17097000

203997_PM_at

203997_at

227944_PM_at

227944_at

31885_at

3219887

3219888

3219889

3219890

3219891

3219892

3219893

3219894

3219895

3219896

3219897

3219898

3219900

3219902

3219903

3219904

3219913

3219914

3219915

3219916

3219917

3219918

3219920

3219923

3219924

3219927

3219928

3219929

3219932

3219933

3219934

3219937

3219939

3219940

3219941

3219942

3219943

3219944

3219954

3219955

3219958

3219959

3219966

43997_at

5774

8163149

A_23_P403898

A_24_P138091

A_24_P928969

GE578127

GE58036

GO:0000165

GO:0000278

GO:0001784

GO:0003824

GO:0004721

GO:0004725

GO:0005515

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0006470

GO:0008092

GO:0009898

GO:0016020

GO:0016311

GO:0016787

GO:0016791

GO:0017080

GO:0023052

GO:0030163

GO:0036211

GO:0042059

GO:0043226

GO:0045930

GO:0048856

GO:0051045

GO:0051117

GO:0055085

GO:0097421

GO:0098772

GO:0098902

GO:0140096

GO:2000649

HMNXSV003017105

HMNXSV003035888

Hs.27004.0.A1_3p_at

ILMN_1717294

M64572_at

PH_hs_0024660

TC09001468.hg

TC09002738.hg

g4506292_3p_at

p33594

Participates

as a component of

p-S459 PTPN3:p-T183,Y185-MAPK12 [cytosol] (Homo sapiens)

Other forms of this molecule

PTPN3 [plasma membrane]

PTPN3 [cytosol]

Inferred To

phospho-Ptpn3 [cytosol] (Rattus norvegicus)

phospho-p-S459 PTPN3 [cytosol] (Bos taurus)

phospho-p-S459 PTPN3 [cytosol] (Caenorhabditis elegans)

phospho-p-S459 PTPN3 [cytosol] (Canis familiaris)

phospho-p-S459 PTPN3 [cytosol] (Drosophila melanogaster)

phospho-p-S459 PTPN3 [cytosol] (Gallus gallus)

phospho-p-S459 PTPN3 [cytosol] (Mus musculus)

phospho-p-S459 PTPN3 [cytosol] (Sus scrofa)

phospho-p-S459 PTPN3 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-serine at 459

Coordinate

459

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

XP_016870446.1, NP_001138842.1, XP_016870444.1, XP_011517191.1, NP_001138843.1, NP_001138840.1, NP_002820.3, XP_006717267.1, NP_001138841.1, XP_006717262.1

OpenTargets

ENSG00000070159

ZINC - Substances

PTN3_HUMAN

ZINC target

P26045

PRO

P26045

PDB

4RI5, 4QUN, 4RI4, 4QUM, 6T36, 4RH9, 8OEP, 8CQY, 4S0G, 4RHG, 2B49, 4RH5, 6HKS

GeneCards

P26045

HPA

ENSG00000070159-PTPN3

Ensembl

ENSG00000070159, ENSP00000395384, ENST00000374541, ENST00000446349, ENSP00000363667, ENST00000412145, ENSP00000416654

Pharos - Targets

P26045

ZINC - Predictions - Purchasable

PTN3_HUMAN

Orphanet

22888

HMDB Protein

HMDBP08935

Interactors (35)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.899	8
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.859	8
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.859	7
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.802	6
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.802	6
UniProt:Q9NNW5 WDR6	1	WDR6 [cytosol] (R-HSA-9715165)	0.718	6
UniProt:P25800 LMO1	1	LMO1 [nucleoplasm] (R-HSA-8956514)	0.718	6
UniProt:Q04828 AKR1C1	1	AKR1C1 [cytosol] (R-HSA-2855253)	0.718	6
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.671	4
UniProt:P42566-1 EPS15			0.65	4
UniProt:Q8TAA9 VANGL1	1	VANGL1 [plasma membrane] (R-HSA-9714275)	0.649	4
UniProt:P10912 GHR	7	p-Y332,Y487,Y627-GHR(19-638) [plasma membrane] (R-HSA-1169226) GHR(257-638) [plasma membrane] (R-HSA-1168803) p-5Y-GHR(19-638) [plasma membrane] (R-HSA-1168904) GHR(19-638) [endosome lumen] (R-HSA-1169263) GHR(19-256) [extracellular region] (R-HSA-1168821) GHR(19-638) [plasma membrane] (R-HSA-982779) GHR activated [plasma membrane] (R-HSA-1168385)	0.645	4
UniProt:Q8TBC3 SHKBP1	1	SHKBP1 [cytosol] (R-HSA-9714849)	0.569	3
UniProt:Q9Y597 KCTD3	1	KCTD3 [plasma membrane] (R-HSA-9714852)	0.569	3
UniProt:Q9UQ35 SRRM2	1	SRRM2 [nucleoplasm] (R-HSA-8865888)	0.569	3
UniProt:Q8NEK8 TET5D			0.556	3
UniProt:P40692 MLH1	3	MLH1 S252* [nucleoplasm] (R-HSA-5444526) MLH1 H329P [nucleoplasm] (R-HSA-5444512) MLH1 [nucleoplasm] (R-HSA-912495)	0.556	3
UniProt:Q5GFL6-3 VWA2			0.556	3
UniProt:Q8TBK6 ZCH10			0.556	3
IntAct:EBI-16429620 CCSB ORF ID			0.556	3
UniProt:Q6ZRS2-3 SRCAP			0.556	3
UniProt:Q14689-6 DIP2A			0.556	3
UniProt:Q9NPJ8 NXT2			0.556	3
UniProt:Q8WV44 TRIM41	1	TRIM41 [cytosol] (R-HSA-5688975)	0.556	3
UniProt:Q9H8W4 PKHF2			0.556	3
UniProt:Q01664 TFAP4			0.556	3
UniProt:Q96QG7 MTMR9	1	MTMR9 [cytosol] (R-HSA-6809239)	0.556	3
UniProt:P08833 IGFBP1	3	p-IGFBP1 [endoplasmic reticulum lumen] (R-HSA-8957029) IGFBP1 [endoplasmic reticulum lumen] (R-HSA-8956699) IGFBP1 [extracellular region] (R-HSA-381513)	0.527	2
UniProt:Q14524 SCN5A	1	SCN5A [plasma membrane] (R-HSA-443382)	0.527	2
UniProt:P55072 VCP	8	Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) VCP [nucleoplasm] (R-HSA-5643745) VCP [secretory granule lumen] (R-HSA-6801039) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [extracellular region] (R-HSA-6806191) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [cytosol] (R-HSA-1181251)	0.524	2
UniProt:P06463 VE6			0.524	4
UniProt:P11473 VDR	2	polySUMO2-VDR [nucleoplasm] (R-HSA-4546376) VDR [nucleoplasm] (R-HSA-375512)	0.524	4
UniProt:P31040 SDHA	2	FAD-SDHA [mitochondrial matrix] (R-HSA-70983) SDHA [mitochondrial matrix] (R-HSA-9854690)	0.499	2
UniProt:Q9ULK5 VANGL2	2	VANGL2 [plasma membrane] (R-HSA-3965373) pS5,S82,S84-VANGL2 [plasma membrane] (R-HSA-4551547)	0.499	2
UniProt:P23508 CRCM			0.499	2

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