Reactome | p-Y-BCAR1 [cytosol]

p-Y-BCAR1 [cytosol]

Stable Identifier

R-HSA-372645

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phosphorylated p130Cas

Locations in the PathwayBrowser

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Hemostasis (Homo sapiens)

- Platelet activation, signaling and aggregation (Homo sapiens)
  - Platelet Aggregation (Plug Formation) (Homo sapiens)
    - Integrin signaling (Homo sapiens)
      - p130Cas linkage to MAPK signaling for integrins (Homo sapiens)
        
        Crk binding to p130cas (Homo sapiens)
        
        CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        p-Y-BCAR1 [cytosol] (Homo sapiens)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        p-Y-BCAR1 [cytosol] (Homo sapiens)
        
        Phosphorylation of BCAR1 by SRC-PTK2 complex (Homo sapiens)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        p-Y-BCAR1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P56945 BCAR1

Gene Names

BCAR1, CAS, CASS1, CRKAS

Chain

chain:1-870

Reference Genes

BioGPS Gene:9564 BCAR1

COSMIC (genes):BCAR1 BCAR1

CTD Gene:9564 BCAR1

dbSNP Gene:9564 BCAR1

ENSEMBL:ENSG00000050820 BCAR1

ENSEMBL_homo_sapiens_GENE:ENSG00000050820.17 BCAR1

HGNC:971 BCAR1

KEGG Gene (Homo sapiens):9564 BCAR1

Monarch:9564 BCAR1

NCBI Gene:9564 BCAR1

OMIM:602941 BCAR1

UCSC:P56945 BCAR1

Reference Transcript

Other Identifiers

11720126_x_at

11747862_x_at

11748644_x_at

11749654_x_at

11750641_x_at

16828427

223116_PM_at

223116_at

3612289

3612290

3612292

3612923

3612924

3612927

3699425

3699427

3699428

3699429

3699430

3699433

3699435

3699436

3699437

3699450

3699451

3699452

3699453

3699462

3699468

3699469

3699470

3699491

3699492

65885_at

8002854

9564

A_23_P66319

A_33_P3369034

GE61124

GE861779

GO:0001558

GO:0001726

GO:0002376

GO:0005515

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005925

GO:0007010

GO:0007015

GO:0007155

GO:0007169

GO:0007173

GO:0007186

GO:0007229

GO:0008286

GO:0010595

GO:0012501

GO:0015629

GO:0016020

GO:0016477

GO:0017124

GO:0019901

GO:0023052

GO:0030027

GO:0030335

GO:0030424

GO:0035729

GO:0042981

GO:0042995

GO:0043226

GO:0048008

GO:0048010

GO:0048011

GO:0048012

GO:0048870

GO:0050851

GO:0050852

GO:0050853

GO:0051301

GO:0060326

GO:0070161

GO:0086100

HMNXSV003008909

ILMN_1672596

PH_hs_0014101

g6740101_3p_at

Participates

as a component of

p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-Y12-BCAR1 [cytosol]

p-Y165,Y664-BCAR1 [cytosol]

BCAR1 [cytosol]

Inferred To

phospho-Bcar1 [cytosol] (Mus musculus)

phospho-Bcar1 [cytosol] (Rattus norvegicus)

phospho-BCAR1 [cytosol] (Bos taurus)

phospho-BCAR1 [cytosol] (Canis familiaris)

phospho-BCAR1 [cytosol] (Sus scrofa)

phospho-p-Y-BCAR1 [cytosol] (Gallus gallus)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001164186.1, NP_001164191.1, NP_001164188.1, NP_001164190.1, NP_001164185.1, NP_055382.2, NP_001164189.1, NP_001164187.1, XP_016879386.1

OpenTargets

ENSG00000050820

GeneCards

P56945

HPA

ENSG00000050820-BCAR1

Ensembl

ENST00000393420, ENST00000393422, ENST00000420641, ENST00000418647, ENSP00000162330, ENST00000542031, ENSP00000440415, ENST00000538440, ENSG00000050820, ENSP00000443841, ENSP00000392708, ENSP00000391669, ENST00000535626, ENSP00000377074, ENSP00000440370, ENST00000162330, ENSP00000377072

PRO

P56945

Pharos - Targets

P56945

PDB

5O2P, 1WYX, 5O2M, 5O2Q, 3T6G

Interactors (34)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.816	7
UniProt:P18031 PTPN1	2	PTPN1 [cytosol] (R-HSA-210625) PTPN1 [endosome membrane] (R-HSA-9815895)	0.786	5
UniProt:P06241 FYN	6	p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) FYN [cytosol] (R-HSA-200917)	0.716	4
UniProt:Q8N5H7-2 SH2D3C			0.693	8
UniProt:Q05209 PTPN12	2	PTPN12 [cytosol] (R-HSA-432933) PTPN12 [nucleoplasm] (R-HSA-9008905)	0.691	5
UniProt:P12931 SRC	6	p-Y419-SRC [nucleoplasm] (R-HSA-8937690) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.688	3
UniProt:O75815 BCAR3			0.643	4
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.615	4
UniProt:O75815-1 BCAR3			0.611	3
UniProt:Q05397 PTK2	11	pY-PTK2 [cytosol] (R-HSA-9632393) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2(773-1052) [cytosol] (R-HSA-202829) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2 [cytosol] (R-HSA-201621) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y-PTK2 [cytosol] (R-HSA-354128)	0.589	2
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.576	4
UniProt:P18206-2 VCL			0.556	3
UniProt:Q5T9C2-3 EEIG1			0.556	3
UniProt:Q49AR9 Q49AR9			0.556	3
UniProt:Q96QH2 PRAM			0.556	3
UniProt:Q86YD7 F90A1			0.556	3
UniProt:P53618 COPB1	8	COPB1 [endoplasmic reticulum membrane] (R-HSA-6810955) COPB1 [Golgi membrane] (R-HSA-6808735) COPB1 [transport vesicle] (R-HSA-6808736) COPB1 [cytosol] (R-HSA-199995) COPB1 [ficolin-1-rich granule membrane] (R-HSA-6800972) COPB1 [secretory granule membrane] (R-HSA-6800914) COPB1 [plasma membrane] (R-HSA-6806431) COPB1 [tertiary granule membrane] (R-HSA-6800175)	0.556	3
UniProt:P06241-3 FYN			0.556	3
UniProt:Q9BZE0 GLIS2			0.556	3
UniProt:Q68CZ2 TNS3	1	TNS3 [cytosol] (R-HSA-8875524)	0.556	8
UniProt:O75604 USP2	2	USP2 [cytosol] (R-HSA-5212661) USP2 [nucleoplasm] (R-HSA-5689946)	0.556	3
UniProt:P07947 YES1	2	MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411) YES1 [cytosol] (R-HSA-373640)	0.556	3
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.556	3
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.536	2
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.527	5
UniProt:Q04205 TENS1			0.524	2
UniProt:Q07912 TNK2	1	TNK2 [cytosol] (R-HSA-9842568)	0.524	5
UniProt:Q9H792 PEAK1	1	PEAK1 [cytosol] (R-HSA-9715162)	0.499	3
UniProt:Q9QWI6 SRCN1			0.499	3
UniProt:Q8N5H7 SH2D3			0.499	2
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.483	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.483	3
UniProt:Q9C0H9 SRCN1			0.463	3
UniProt:P50281 MMP14	4	MMP14 [Golgi membrane] (R-HSA-9858808) MMP14(21-582) [Golgi lumen] (R-HSA-1604689) MMP14 [Golgi lumen] (R-HSA-1604724) MMP14 [plasma membrane] (R-HSA-1442472)	0.463	3

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