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TSC2 [cytosol]
Stable Identifier
R-HSA-2980548
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Tuberin, TSC2_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by AKT1 E17K in Cancer (Homo sapiens)
AKT1 E17K mutant phosphorylates TSC2, inhibiting it (Homo sapiens)
TSC2 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Metabolic Genes (Homo sapiens)
AKT phosphorylates TSC2, inhibiting it (Homo sapiens)
TSC2 [cytosol] (Homo sapiens)
Formation of TSC1:TSC2 complex (Homo sapiens)
TSC1:TSC2 [cytosol] (Homo sapiens)
TSC2 [cytosol] (Homo sapiens)
TSC2 [cytosol] (Homo sapiens)
p-AMPK phosphorylates TSC1:TSC2 (Homo sapiens)
TSC1:TSC2 [cytosol] (Homo sapiens)
TSC2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
AKT phosphorylates targets in the cytosol (Homo sapiens)
AKT phosphorylates TSC2, inhibiting it (Homo sapiens)
TSC2 [cytosol] (Homo sapiens)
MTOR signalling (Homo sapiens)
Energy dependent regulation of mTOR by LKB1-AMPK (Homo sapiens)
p-AMPK phosphorylates TSC1:TSC2 (Homo sapiens)
TSC1:TSC2 [cytosol] (Homo sapiens)
TSC2 [cytosol] (Homo sapiens)
Inhibition of TSC complex formation by PKB (Homo sapiens)
Phosphorylation of TSC2 by PKB (Homo sapiens)
TSC2 [cytosol] (Homo sapiens)
Phosphorylation of complexed TSC2 by PKB (Homo sapiens)
TSC1:TSC2 [cytosol] (Homo sapiens)
TSC2 [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Rab regulation of trafficking (Homo sapiens)
TBC/RABGAPs (Homo sapiens)
TBC1D7 binds the TSC1-TSC2 complex (Homo sapiens)
TBC1D7:TSC1:TSC2 [cytosol] (Homo sapiens)
TSC1:TSC2 [cytosol] (Homo sapiens)
TSC2 [cytosol] (Homo sapiens)
TSC1:TSC2 [cytosol] (Homo sapiens)
TSC2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49815 TSC2
Gene Names
TSC2, TSC4
Chain
chain:1-1807
Reference Genes
COSMIC (genes):TSC2 TSC2
dbSNP Gene:7249 TSC2
ENSEMBL:ENSG00000103197 TSC2
Participates
as an input of
AKT1 E17K mutant phosphorylates TSC2, inhibiting it (Homo sapiens)
Phosphorylation of TSC2 by PKB (Homo sapiens)
AKT phosphorylates TSC2, inhibiting it (Homo sapiens)
Formation of TSC1:TSC2 complex (Homo sapiens)
as a component of
TSC1:TSC2 [cytosol] (Homo sapiens)
Other forms of this molecule
p-S939,S1130,T1462-TSC2 [cytosol]
p-S939,T1462-TSC2 [cytosol]
p-S1387-TSC2 [cytosol]
Inferred To
TSC2 [cytosol]
(Bos taurus)
TSC2 [cytosol]
(Canis familiaris)
TSC2 [cytosol]
(Dictyostelium discoideum)
TSC2 [cytosol]
(Gallus gallus)
TSC2 [cytosol]
(Sus scrofa)
tsc2 [cytosol]
(Schizosaccharomyces pombe)
tsc2 [cytosol]
(Xenopus tropicalis)
gig [cytosol]
(Drosophila melanogaster)
Tsc2 [cytosol]
(Mus musculus)
Tsc2 [cytosol]
(Rattus norvegicus)
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.945
15
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.937
12
UniProt:Q92574 TSC1
2
TSC1 [cytosol]
(R-HSA-5672338)
TSC1 [plasma membrane]
(R-HSA-165169)
0.935
13
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.87
9
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.851
8
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.816
6
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.675
3
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.571
3
UniProt:O00141 SGK1
4
p-T256,S422-SGK1 [nucleoplasm]
(R-HSA-9612512)
p-T256,S422-SGK1 [cytosol]
(R-HSA-6795449)
p-S422-SGK1 [cytosol]
(R-HSA-6795313)
SGK1 [cytosol]
(R-HSA-2682356)
0.563
4
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.544
2
UniProt:Q9P0N9 TBC1D7
1
TBC1D7 [cytosol]
(R-HSA-8854154)
0.528
3
UniProt:P03126 VE6
0.527
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.508
2
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