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p-S589,S595-CENPJ [cytosol]
Stable Identifier
R-HSA-6801670
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)
PLK2 phosphorylates CENPJ (Homo sapiens)
p-S589,S595-CENPJ [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9HC77 CENPJ
Gene Names
CENPJ, CPAP, LAP, LIP1
Chain
chain:1-1338
Reference Genes
BioGPS Gene:55835 CENPJ
COSMIC (genes):CENPJ CENPJ
CTD Gene:55835 CENPJ
dbSNP Gene:55835 CENPJ
ENSEMBL:ENSG00000151849 CENPJ
HGNC:17272 CENPJ
KEGG:hsa:55835 CENPJ
Monarch:55835 CENPJ
NCBI Gene:55835 CENPJ
OMIM:609279 CENPJ
UCSC:Q9HC77 CENPJ
Reference Transcript
RefSeq:NM_018451.4 CENPJ
Other Identifiers
11734866_at
11754425_a_at
16777502
220885_3p_s_at
220885_PM_s_at
220885_s_at
223513_PM_at
223513_at
234023_PM_s_at
234023_s_at
3505938
3505939
3505940
3505941
3505942
3505943
3505944
3505945
3505946
3505947
3505948
3505949
3505950
3505954
3505955
3505956
3505957
3505958
3505959
3505962
3505963
3505964
3505965
3505968
3505969
3505970
3505971
3505972
3505973
3505974
3505975
3505977
3505978
3505979
3505980
3505986
55835
56067_at
7970624
81357_at
A_24_P298996
A_32_P219116
GE82379
GO:0003713
GO:0005515
GO:0005737
GO:0005813
GO:0005814
GO:0005815
GO:0005829
GO:0005856
GO:0005874
GO:0006355
GO:0007010
GO:0007020
GO:0007099
GO:0007224
GO:0008092
GO:0008275
GO:0015631
GO:0019901
GO:0019904
GO:0030954
GO:0036064
GO:0042802
GO:0043015
GO:0043226
GO:0044458
GO:0044782
GO:0045893
GO:0046427
GO:0046599
GO:0046601
GO:0046785
GO:0051298
GO:0051301
GO:0060090
GO:0060236
GO:0060271
GO:0061511
GO:0065003
GO:0098534
GO:0120099
GO:0140110
GO:1900087
GO:1902857
GO:1903724
GO:1904951
GO:1905515
GO:1905832
HMNXSV003019229
HMNXSV003045328
Hs.283077.2.S1_3p_a_at
ILMN_1661776
PH_hs_0025316
TC13000493.hg
g10643591_3p_at
g8922088_3p_a_at
Participates
as an output of
PLK2 phosphorylates CENPJ (Homo sapiens)
Other forms of this molecule
CENPJ [cytosol]
Inferred To
phospho-p-S589,S595-CENPJ [cytosol]
(Gallus gallus)
phospho-cenpj [cytosol]
(Danio rerio)
phospho-Cenpj [cytosol]
(Mus musculus)
phospho-Cenpj [cytosol]
(Rattus norvegicus)
phospho-Sas-4 [cytosol]
(Drosophila melanogaster)
phospho-CENPJ [cytosol]
(Bos taurus)
phospho-CENPJ [cytosol]
(Canis familiaris)
phospho-CENPJ [cytosol]
(Sus scrofa)
Modified Residues
Name
O-phospho-L-serine at 589
Coordinate
589
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 595
Coordinate
595
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_060921.3
OpenTargets
ENSG00000151849
ENSEMBL
ENSP00000477511
,
ENST00000616936
,
ENSP00000371308
,
ENST00000381884
HPA
ENSG00000151849-CENPJ
PRO
Q9HC77
Pharos - Targets
Q9HC77
Orphanet
CENPJ
GlyGen
Q9HC77
PDB
7Q1F
,
5EIB
,
7Z0G
,
5ITZ
,
7Z0F
,
7Q1E
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15468 STIL
0.82
15
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.725
4
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.706
4
UniProt:Q66GS9 CEP135
1
CEP135 [cytosol]
(R-HSA-380266)
0.702
8
UniProt:Q6UVJ0 SAS6
0.671
7
UniProt:Q9HC77 CENPJ
2
CENPJ [cytosol]
(R-HSA-380291)
p-S589,S595-CENPJ [cytosol]
(R-HSA-6801670)
0.618
3
UniProt:Q7Z460 CLASP1
1
CLASP1 [cytosol]
(R-HSA-376230)
0.615
3
UniProt:Q9P287 BCCIP
0.556
3
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.527
2
UniProt:Q13509 TUBB3
6
TUBB3 [cytosol]
(R-HSA-190532)
TUBB3 [axonemal microtubule]
(R-HSA-5610436)
Polyglutamyl-TUBB3 [cytosol]
(R-HSA-8867464)
Polyglycyl-TUBB3 [cytosol]
(R-HSA-8867372)
TUBB3 unfolded [cytosol]
(R-HSA-392770)
TUBB3 folding intermediate [cytosol]
(R-HSA-392806)
0.527
2
UniProt:P52815 MRPL12
2
MRPL12 [mitochondrial inner membrane]
(R-HSA-5368256)
MRPL12 [mitochondrial matrix]
(R-HSA-9839674)
0.527
2
UniProt:O75122 CLASP2
1
CLASP2 [cytosol]
(R-HSA-376252)
0.527
2
UniProt:Q5VTD9 GFI1B
0.508
2
UniProt:Q96RK0 CIC
0.508
2
UniProt:Q71U36 TUBA1A
9
TUBA1A [cytosol]
(R-HSA-191689)
TUBA1A [axonemal microtubule]
(R-HSA-5610433)
TUBA1A(1-450) [cytosol]
(R-HSA-8955577)
Polyglutamyl-TUBA1A [cytosol]
(R-HSA-8867408)
L-isoglutamyl polyglycyl-TUBA1A [cytosol]
(R-HSA-8867428)
TUBA1A unfolded [cytosol]
(R-HSA-392767)
TUBA1A folding intermediate [cytosol]
(R-HSA-392805)
Ac K40 TUBA1A [axonemal microtubule]
(R-HSA-5624852)
AcK-TUBA1A [cytosol]
(R-HSA-5618312)
0.483
2
UniProt:Q6UUV7 CRTC3
1
CRTC3 [nucleoplasm]
(R-HSA-8931950)
0.483
2
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.483
2
UniProt:Q15154 PCM1
1
PCM1 [cytosol]
(R-HSA-380308)
0.483
3
UniProt:O95271 TNKS
1
TNKS [cytosol]
(R-HSA-3640825)
0.463
4
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