Reactome | p-Y-IRS1 [cytosol]

p-Y-IRS1 [cytosol]

Stable Identifier

R-HSA-74772

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-IRS1, Insulin receptor substrate-1, IRS-1

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by ALK in cancer (Homo sapiens)
    - Signaling by ALK fusions and activated point mutants (Homo sapiens)
      - ALK fusions phosphorylate IRS1 (Homo sapiens)
        
        p-Y IRS1:ALK fusion proteins [cytosol] (Homo sapiens)
        
        p-Y-IRS1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P35568 IRS1

Gene Names

IRS1

Chain

chain:1-1242

Reference Genes

BioGPS Gene:3667 IRS1

COSMIC (genes):IRS1 IRS1

CTD Gene:3667 IRS1

dbSNP Gene:3667 IRS1

ENSEMBL:ENSG00000169047 IRS1

HGNC:6125 IRS1

KEGG:hsa:3667 IRS1

Monarch:3667 IRS1

NCBI Entrez Gene:3667 IRS1

OMIM:147545 IRS1

UCSC:P35568 IRS1

Reference Transcript

Other Identifiers

11743627_a_at

11743628_at

11743629_at

16909165

204686_PM_at

204686_at

235392_PM_at

235392_at

238933_PM_at

238933_at

242979_PM_at

242979_at

2602018

2602019

2602020

2602030

2602031

2602032

2602033

2602036

2602037

2602038

2602039

2602040

2602041

2602042

2602043

2602044

2602045

2602046

2602047

2602048

2602049

2602050

2602051

2602073

2602074

2602075

2602085

2602087

3667

41049_at

47353_at

51048_r_at

75148_at

8059470

850_r_at

851_s_at

872_i_at

A_24_P225679

A_24_P654792

A_24_P802145

GE58787

GE88543

GO:0001784

GO:0005068

GO:0005080

GO:0005102

GO:0005158

GO:0005159

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0005899

GO:0005901

GO:0007165

GO:0008284

GO:0008286

GO:0009967

GO:0010907

GO:0019221

GO:0030159

GO:0032000

GO:0032868

GO:0032869

GO:0035591

GO:0042169

GO:0042593

GO:0043226

GO:0043231

GO:0043491

GO:0043548

GO:0045725

GO:0046326

GO:0046627

GO:0046628

GO:0046676

GO:0048009

GO:0051897

GO:0060090

GO:0071398

HMNXSV003036377

Hs.257786.0.A1_3p_at

Hs.43845.0.A1_3p_at

Hs.59896.0.A1_3p_at

ILMN_1759232

ILMN_1900110

PH_hs_0024522

S62539_at

TC02002830.hg

TC02004835.hg

g5031804_3p_at

Participates

as a component of

as a member of

p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)

Other forms of this molecule

p-Y-IRS1 [plasma membrane]

IRS1 [cytosol]

IRS1 [plasma membrane]

p-6Y-IRS1 [plasma membrane]

Inferred To

phospho-IRS1 [cytosol] (Bos taurus)

phospho-IRS1 [cytosol] (Canis familiaris)

phospho-IRS1 [cytosol] (Sus scrofa)

phospho-irs1 [cytosol] (Xenopus tropicalis)

phospho-p-Y-IRS1 [cytosol] (Gallus gallus)

phospho-chico [cytosol] (Drosophila melanogaster)

phospho-Irs1 [cytosol] (Mus musculus)

phospho-Irs1 [cytosol] (Rattus norvegicus)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_054197850.1, NP_005535.1, XP_047300179.1, XP_047300180.1

OpenTargets

ENSG00000169047

ENSEMBL

ENSP00000304895, ENST00000305123, ENSG00000169047

HPA

ENSG00000169047-IRS1

GeneCards

IRS1

PRO

P35568

Pharos - Targets

P35568

GlyGen

P35568

PDB

1K3A, 6BNT, 2Z8C, 1QQG, 7PPM, 7PPL, 1IRS, 5U1M

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.921	13
UniProt:P42336 PIK3CA	20	PIK3CA H1047L [cytosol] (R-HSA-1500714) PIK3CA H1047R [cytosol] (R-HSA-1500716) PIK3CA [cytosol] (R-HSA-74787) PIK3CA R38C [cytosol] (R-HSA-1500691) PIK3CA R38G [cytosol] (R-HSA-2395950) PIK3CA R38S [cytosol] (R-HSA-2395947) PIK3CA R38H [cytosol] (R-HSA-1500718) PIK3CA E542Q [cytosol] (R-HSA-2328003) PIK3CA Q546P [cytosol] (R-HSA-1500695) PIK3CA Q546R [cytosol] (R-HSA-2362373) PIK3CA Q546H [cytosol] (R-HSA-2362374) PIK3CA E545G [cytosol] (R-HSA-1500709) PIK3CA Q546L [cytosol] (R-HSA-2362375) PIK3CA E542V [cytosol] (R-HSA-2328074) PIK3CA E545V [cytosol] (R-HSA-2362365) PIK3CA Q546E [cytosol] (R-HSA-2362383) PIK3CA E545Q [cytosol] (R-HSA-2362362) PIK3CA E545K [cytosol] (R-HSA-1500706) PIK3CA E545A [cytosol] (R-HSA-2362355) PIK3CA Q546K [cytosol] (R-HSA-1500705)	0.853	42
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.76	8
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.727	5
UniProt:P06213 INSR	6	p-6Y-INSR(763-1382) [endosome membrane] (R-HSA-141719) INSR(763-1382) [endosome membrane] (R-HSA-141722) INSR(28-758) [endosome membrane] (R-HSA-141718) INSR(763-1382) [plasma membrane] (R-HSA-74669) p-6Y-INSR(763-1382) [plasma membrane] (R-HSA-74670) INSR(28-758) [plasma membrane] (R-HSA-74668)	0.704	5
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.674	5
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.671	4
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.589	2
UniProt:O75815 BCAR3			0.57	3
UniProt:P27986-2 PIK3R1			0.57	3
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.527	2
UniProt:P03495 NS1			0.508	2
UniProt:P09217 Prkcz	7	Protein kinase C, zeta type, phosphorylated [cytosol] (R-RNO-437269) Protein kinase C, zeta type [cytosol] (R-RNO-113489) phospho-pS, p-T410-PRKCZ [cytosol] (R-RNO-9632824) PRKCZ [cytosol] (R-RNO-58218) phospho-p-T410,T563-PRKCZ [cytosol] (R-RNO-5218698) phospho-p-T410-PRKCZ [cytosol] (R-RNO-437181) PRKCZ [cell junction] (R-RNO-2134483)	0.502	2
UniProt:P11940 PABPC1	1	PABPC1 [cytosol] (R-HSA-156803)	0.499	2
UniProt:P49757 NUMB	1	NUMB [plasma membrane] (R-HSA-443595)	0.488	2
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.483	2