Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
MITF [nucleoplasm]
Stable Identifier
R-HSA-201592
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Microphthalmia-associated transcription factor, Class E basic helix-loop-helix protein 32, bHLHe32
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
MITF-M-dependent gene expression (Homo sapiens)
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence (Homo sapiens)
MITF-M-dependent MCM5 gene expression (Homo sapiens)
MITF dimer [nucleoplasm] (Homo sapiens)
MITF,TFE3,TFEB,TFEC [nucleoplasm] (Homo sapiens)
MITF [nucleoplasm] (Homo sapiens)
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation (Homo sapiens)
MITF-M-dependent CDC25B gene expression (Homo sapiens)
MITF dimer [nucleoplasm] (Homo sapiens)
MITF,TFE3,TFEB,TFEC [nucleoplasm] (Homo sapiens)
MITF [nucleoplasm] (Homo sapiens)
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition (Homo sapiens)
MITF-M-dependent CDH1 gene expression (Homo sapiens)
MITF dimer [nucleoplasm] (Homo sapiens)
MITF,TFE3,TFEB,TFEC [nucleoplasm] (Homo sapiens)
MITF [nucleoplasm] (Homo sapiens)
MITF-M-dependent GXYLT2 gene expression (Homo sapiens)
MITF dimer [nucleoplasm] (Homo sapiens)
MITF,TFE3,TFEB,TFEC [nucleoplasm] (Homo sapiens)
MITF [nucleoplasm] (Homo sapiens)
MITF-M-dependent SOX2 gene expression (Homo sapiens)
MITF dimer [nucleoplasm] (Homo sapiens)
MITF,TFE3,TFEB,TFEC [nucleoplasm] (Homo sapiens)
MITF [nucleoplasm] (Homo sapiens)
MITF-M-dependent STT3B gene expression (Homo sapiens)
MITF dimer [nucleoplasm] (Homo sapiens)
MITF,TFE3,TFEB,TFEC [nucleoplasm] (Homo sapiens)
MITF [nucleoplasm] (Homo sapiens)
MITF-M-dependent ZEB1 gene expression (Homo sapiens)
MITF dimer [nucleoplasm] (Homo sapiens)
MITF,TFE3,TFEB,TFEC [nucleoplasm] (Homo sapiens)
MITF [nucleoplasm] (Homo sapiens)
Transcriptional and post-translational regulation of MITF-M expression and activity (Homo sapiens)
MITF dimerizes (Homo sapiens)
MITF dimer [nucleoplasm] (Homo sapiens)
MITF,TFE3,TFEB,TFEC [nucleoplasm] (Homo sapiens)
MITF [nucleoplasm] (Homo sapiens)
MITF,TFE3,TFEB,TFEC [nucleoplasm] (Homo sapiens)
MITF [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of transcription factors (Homo sapiens)
PIAS3 SUMOylates MITF with SUMO1 (Homo sapiens)
MITF [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75030 MITF
Gene Names
MITF, BHLHE32
Chain
chain:1-526
Reference Genes
BioGPS Gene:4286 MITF
COSMIC (genes):MITF MITF
CTD Gene:4286 MITF
dbSNP Gene:4286 MITF
ENSEMBL:ENSG00000187098 MITF
HGNC:7105 MITF
KEGG:hsa:4286 MITF
Monarch:4286 MITF
NCBI Gene:4286 MITF
OMIM:156845 MITF
UCSC:O75030 MITF
Reference Transcript
RefSeq:XM_005264754.1 MITF
RefSeq:NM_198177.2 MITF
RefSeq:NM_006722.2 MITF
RefSeq:NM_198178.2 MITF
RefSeq:XM_017006444.1 MITF
RefSeq:NM_198159.2 MITF
RefSeq:XM_005264755.3 MITF
RefSeq:NM_198158.2 MITF
RefSeq:NM_000248.3 MITF
RefSeq:NM_001184967.1 MITF
RefSeq:XM_017006448.1 MITF
Participates
as an input of
PIAS3 SUMOylates MITF with SUMO1 (Homo sapiens)
as a member of
MITF,TFE3,TFEB,TFEC [nucleoplasm] (Homo sapiens)
Other forms of this molecule
monoSUMO1-K289,423-MITF [nucleoplasm]
Inferred To
hlh-30 [nucleoplasm]
(Caenorhabditis elegans)
mitf [nucleoplasm]
(Xenopus tropicalis)
MITF [nucleoplasm]
(Bos taurus)
MITF [nucleoplasm]
(Canis familiaris)
MITF [nucleoplasm]
(Gallus gallus)
MITF [nucleoplasm]
(Sus scrofa)
Mitf [nucleoplasm]
(Drosophila melanogaster)
Mitf [nucleoplasm]
(Mus musculus)
Mitf [nucleoplasm]
(Rattus norvegicus)
RTG3 [nucleoplasm]
(Saccharomyces cerevisiae)
mitfb [nucleoplasm]
(Danio rerio)
Cross References
OpenTargets
ENSG00000187098
ENSEMBL
ENSP00000377880
,
ENSP00000418845
,
ENST00000352241
,
ENST00000314589
,
ENST00000314557
,
ENST00000448226
,
ENSP00000324443
,
ENST00000642352
,
ENSP00000324246
,
ENSP00000494105
,
ENSG00000187098
,
ENST00000531774
,
ENSP00000435909
,
ENST00000394351
,
ENSP00000391803
,
ENSP00000295600
,
ENST00000472437
HPA
ENSG00000187098-MITF
GeneCards
MITF
PRO
O75030
Pharos - Targets
O75030
Orphanet
MITF
GlyGen
O75030
PDB
7D8T
,
7D8R
,
7D8S
,
4C7N
,
7EOD
,
8E1D
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.615
3
UniProt:P19484 TFEB
1
TFEB [nucleoplasm]
(R-HSA-9857368)
0.564
3
UniProt:P19532 TFE3
1
TFE3 [nucleoplasm]
(R-HSA-9857366)
0.564
2
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.527
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text