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WWC1 [cytosol]
Stable Identifier
R-HSA-2038400
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
KIBRA
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Hippo (Homo sapiens)
KIBRA (WWC1) binds LATS proteins (Homo sapiens)
KIBRA:LATS [cytosol] (Homo sapiens)
WWC1 [cytosol] (Homo sapiens)
WWC1 [cytosol] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH3 (Homo sapiens)
NOTCH3 Intracellular Domain Regulates Transcription (Homo sapiens)
WWC1 (Kibra) gene expression is stimulated by NOTCH3 (Homo sapiens)
WWC1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IX03 WWC1
Gene Names
WWC1, KIAA0869
Chain
chain:1-1113
Reference Genes
BioGPS Gene:23286 WWC1
COSMIC (genes):WWC1 WWC1
CTD Gene:23286 WWC1
dbSNP Gene:23286 WWC1
ENSEMBL:ENSG00000113645 WWC1
ENSEMBL:ENSG00000113645.15 WWC1
HGNC:29435 WWC1
KEGG Gene (Homo sapiens):23286 WWC1
Monarch:23286 WWC1
NCBI Gene:23286 WWC1
OMIM:610533 WWC1
UCSC:Q8IX03 WWC1
Reference Transcript
RefSeq:NM_015238.2 WWC1
RefSeq:NM_001161661.1 WWC1
RefSeq:NM_001161662.1 WWC1
Other Identifiers
11729267_a_at
16991991
213085_PM_s_at
213085_s_at
216074_PM_x_at
216074_x_at
229180_PM_at
229180_at
23286
241950_PM_at
241950_at
2839545
2839546
2839547
2839599
2839601
2839603
2839605
2839608
2839609
2839610
2839611
2839618
2839619
2839623
2839624
2839625
2839626
2839627
2839628
2839629
2839630
2839631
2839632
2839635
2839636
2839640
2839644
2839645
2839647
2839648
2839653
2839656
2839657
2839660
2839661
2839662
2839663
2839664
2839665
2839666
2839667
2839668
2839669
2839670
34213_at
60941_at
62767_at
8109773
A_14_P105088
A_23_P81392
GE53550
GE874742
GO:0000122
GO:0003713
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0007163
GO:0016020
GO:0016477
GO:0019900
GO:0023052
GO:0030010
GO:0032386
GO:0032587
GO:0032991
GO:0035330
GO:0035331
GO:0042995
GO:0043226
GO:0043410
GO:0045893
GO:0046621
GO:0048471
GO:0048870
GO:0060090
GO:0110165
GO:0140110
HMNXSV003004739
Hs.18140.0.A1_3p_at
Hs.21543.0.A1_3p_a_at
Hs.21543.2.A1_3p_a_at
Hs.21543.2.A1_3p_x_at
Hs.71994.0.A1_3p_at
ILMN_1658619
PH_hs_0025318
TC05000917.hg
Participates
as an output of
WWC1 (Kibra) gene expression is stimulated by NOTCH3 (Homo sapiens)
as a component of
KIBRA:LATS [cytosol] (Homo sapiens)
as an input of
KIBRA (WWC1) binds LATS proteins (Homo sapiens)
Inferred To
WWC1 [cytosol]
(Bos taurus)
WWC1 [cytosol]
(Canis familiaris)
WWC1 [cytosol]
(Danio rerio)
WWC1 [cytosol]
(Gallus gallus)
WWC1 [cytosol]
(Sus scrofa)
wwc1 [cytosol]
(Xenopus tropicalis)
kibra [cytosol]
(Drosophila melanogaster)
dwwA [cytosol]
(Dictyostelium discoideum)
Wwc1 [cytosol]
(Mus musculus)
Wwc1 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_001155133.1
,
NP_056053.1
,
NP_001155134.1
OpenTargets
ENSG00000113645
GeneCards
Q8IX03
HPA
ENSG00000113645-WWC1
Ensembl
ENSG00000113645
,
ENSP00000427772
,
ENSP00000265293
,
ENST00000521089
,
ENST00000265293
PRO
Q8IX03
Pharos - Targets
Q8IX03
PDB
6FJC
,
2Z0U
,
6FD0
,
6FB4
,
6FJD
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UKE5 TNIK
1
TNIK [cytosol]
(R-HSA-3214889)
0.553
2
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.527
2
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.527
2
UniProt:Q4VCS5 AMOT
0.483
2
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