Reactome | WWC1 [cytosol]

WWC1 [cytosol]

Stable Identifier

R-HSA-2038400

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

KIBRA

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8IX03 WWC1

Gene Names

WWC1, KIAA0869, KIBRA

Chain

chain:1-1113

Reference Genes

BioGPS Gene:23286 WWC1

COSMIC (genes):WWC1 WWC1

CTD Gene:23286 WWC1

dbSNP Gene:23286 WWC1

ENSEMBL:ENSG00000113645 WWC1

HGNC:29435 WWC1

KEGG:hsa:23286 WWC1

Monarch:23286 WWC1

NCBI Gene:23286 WWC1

OMIM:610533 WWC1

UCSC:Q8IX03 WWC1

Reference Transcript

Participates

as an output of

WWC1 (Kibra) gene expression is stimulated by NOTCH3 (Homo sapiens)

as a component of

KIBRA:LATS [cytosol] (Homo sapiens)

as an input of

KIBRA (WWC1) binds LATS proteins (Homo sapiens)

Inferred To

WWC1 [cytosol] (Bos taurus)

WWC1 [cytosol] (Canis familiaris)

WWC1 [cytosol] (Gallus gallus)

WWC1 [cytosol] (Sus scrofa)

wwc1 [cytosol] (Xenopus tropicalis)

Dmel\CG10508 [cytosol] (Drosophila melanogaster)

kibra [cytosol] (Drosophila melanogaster)

Wwc1 [cytosol] (Mus musculus)

Wwc1 [cytosol] (Rattus norvegicus)

Homologues of WWC1 [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_001155133.1, NP_001155134.1, NP_056053.1

OpenTargets

ENSG00000113645

ENSEMBL

ENST00000521089, ENSP00000265293, ENSG00000113645, ENST00000265293, ENSP00000427772

HPA

ENSG00000113645-WWC1

GeneCards

WWC1

PRO

Q8IX03

Pharos - Targets

Q8IX03

GlyGen

Q8IX03

PDB

2Z0U, 6FB4, 6FJC, 6FJD, 6FD0

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96FJ2 DYNLL2	4	DYNLL2 [cytosol] (R-HSA-2029024) DYNLL2 [plasma membrane] (R-HSA-140527) DYNLL2 [cilium] (R-HSA-5624865) DYNLL2 [ciliary tip] (R-HSA-5625337)	0.725	4
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.725	4
UniProt:P63167 DYNLL1	6	DYNLL1 [cytosol] (R-HSA-387105) DYNLL1 [plasma membrane] (R-HSA-54017) DYNLL1 [tertiary granule membrane] (R-HSA-6801482) DYNLL1 [ficolin-1-rich granule membrane] (R-HSA-6801518) DYNLL1 [cilium] (R-HSA-5624863) DYNLL1 [ciliary tip] (R-HSA-5625335)	0.643	3
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.643	3
UniProt:Q4VCS5 AMOT			0.615	3
UniProt:Q9UKE5 TNIK	1	TNIK [cytosol] (R-HSA-3214889)	0.553	2
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.527	2
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.527	2
UniProt:Q15678 PTPN14	1	PTPN14 [nucleoplasm] (R-HSA-9008917)	0.527	2
UniProt:Q8TCX5 RHPN1	1	RHPN1 [cytosol] (R-HSA-5667017)	0.527	2
UniProt:O43491 EPB41L2	1	EPB41L2 [cytosol] (R-HSA-6797548)	0.527	2
UniProt:Q8N5I2 ARRD1			0.527	2
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.527	2
UniProt:Q9Y2J2 EPB41L3	1	EPB41L3 [cytosol] (R-HSA-6797563)	0.527	2
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.527	2
UniProt:Q9UKB1 FBXW11	2	FBXW11 [cytosol] (R-HSA-976035) FBXW11 [nucleoplasm] (R-HSA-9953055)	0.527	2
UniProt:Q05513 PRKCZ	5	PRKCZ [cell junction] (R-HSA-2134483) p-T410-PRKCZ [cytosol] (R-HSA-437181) pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824) PRKCZ [cytosol] (R-HSA-58218) p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698)	0.527	4

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