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PTPN3 [cytosol]
Stable Identifier
R-HSA-8867650
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Tyrosine-protein phosphatase non-receptor type 3 ecNumber3.1.3.48/ecNumber, PTN3_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
Negative regulation of MAPK pathway (Homo sapiens)
MAPK12 phosphorylates PTPN3 (Homo sapiens)
PTPN3:p-T183,Y185-MAPK12 [cytosol] (Homo sapiens)
PTPN3 [cytosol] (Homo sapiens)
PTPN3 binds p-T183,Y185 MAPK12 (Homo sapiens)
PTPN3 [cytosol] (Homo sapiens)
PTPN3:p-T183,Y185-MAPK12 [cytosol] (Homo sapiens)
PTPN3 [cytosol] (Homo sapiens)
PTPN3 dephosphorylates MAPK12 (Homo sapiens)
PTPN3 [cytosol] (Homo sapiens)
PTPN3:p-T183,Y185-MAPK12 [cytosol] (Homo sapiens)
PTPN3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P26045 PTPN3
Gene Names
PTPN3, PTPH1
Chain
chain:1-913
Reference Genes
BioGPS Gene:5774 PTPN3
COSMIC (genes):PTPN3 PTPN3
CTD Gene:5774 PTPN3
dbSNP Gene:5774 PTPN3
ENSEMBL:ENSG00000070159 PTPN3
HGNC:9655 PTPN3
KEGG:hsa:5774 PTPN3
Monarch:5774 PTPN3
NCBI Gene:5774 PTPN3
OMIM:176877 PTPN3
UCSC:P26045 PTPN3
Reference Transcript
RefSeq:XM_006717199.3 PTPN3
RefSeq:XM_006717204.3 PTPN3
RefSeq:XM_017014955.1 PTPN3
RefSeq:NM_001145368.1 PTPN3
RefSeq:NM_001145371.1 PTPN3
RefSeq:NM_002829.3 PTPN3
RefSeq:NM_001145370.1 PTPN3
RefSeq:XM_017014957.1 PTPN3
RefSeq:NM_001145369.1 PTPN3
RefSeq:XM_011518889.2 PTPN3
Other Identifiers
11739618_a_at
11739619_a_at
11740363_a_at
11740364_a_at
11740367_a_at
11740368_s_at
11741134_a_at
1458_at
17097000
203997_PM_at
203997_at
227944_PM_at
227944_at
31885_at
3219887
3219888
3219889
3219890
3219891
3219892
3219893
3219894
3219895
3219896
3219897
3219898
3219900
3219902
3219903
3219904
3219905
3219906
3219907
3219908
3219913
3219914
3219915
3219916
3219917
3219918
3219920
3219923
3219924
3219927
3219928
3219929
3219932
3219933
3219934
3219937
3219939
3219940
3219941
3219942
3219943
3219944
3219954
3219955
3219958
3219959
3219966
43997_at
5774
8163149
A_23_P403898
A_24_P138091
A_24_P928969
GE578127
GE58036
GO:0000165
GO:0001784
GO:0003824
GO:0004721
GO:0004725
GO:0005515
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0006470
GO:0008092
GO:0009898
GO:0016311
GO:0016787
GO:0017080
GO:0042059
GO:0043226
GO:0045930
GO:0048856
GO:0051045
GO:0051117
GO:0097421
GO:0098772
GO:0098902
GO:0140096
GO:2000649
HMNXSV003017105
HMNXSV003035888
Hs.27004.0.A1_3p_at
ILMN_1717294
M64572_at
PH_hs_0024660
TC09001468.hg
TC09002738.hg
g4506292_3p_at
p33594
Participates
as an output of
PTPN3 dephosphorylates MAPK12 (Homo sapiens)
as a component of
PTPN3:p-T183,Y185-MAPK12 [cytosol] (Homo sapiens)
as an input of
PTPN3 binds p-T183,Y185 MAPK12 (Homo sapiens)
Other forms of this molecule
p-S459 PTPN3 [cytosol]
PTPN3 [plasma membrane]
Inferred To
Ptpn3 [cytosol]
(Rattus norvegicus)
PTPN3 [cytosol]
(Bos taurus)
PTPN3 [cytosol]
(Caenorhabditis elegans)
PTPN3 [cytosol]
(Canis familiaris)
PTPN3 [cytosol]
(Drosophila melanogaster)
PTPN3 [cytosol]
(Gallus gallus)
PTPN3 [cytosol]
(Mus musculus)
PTPN3 [cytosol]
(Sus scrofa)
PTPN3 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001138842.1
,
XP_011517191.1
,
NP_001138840.1
,
NP_002820.3
,
XP_006717262.1
,
XP_006717267.1
,
NP_001138843.1
,
XP_016870446.1
,
NP_001138841.1
,
XP_016870444.1
OpenTargets
ENSG00000070159
ENSEMBL
ENSP00000363667
,
ENSP00000395384
,
ENST00000412145
,
ENST00000446349
,
ENST00000374541
,
ENSP00000416654
HPA
ENSG00000070159-PTPN3
ZINC - Substances
PTN3_HUMAN
ZINC target
P26045
PRO
P26045
Pharos - Targets
P26045
Orphanet
PTPN3
ZINC - Predictions - Purchasable
PTN3_HUMAN
HMDB Protein
HMDBP08935
PDB
4RHG
,
4RH9
,
4QUM
,
4S0G
,
4QUN
,
6HKS
,
4RI4
,
4RI5
,
4RH5
,
8CQY
,
2B49
,
8OEP
,
6T36
Interactors (35)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.899
8
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.859
8
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.859
7
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.802
6
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.802
6
UniProt:Q04828 AKR1C1
1
AKR1C1 [cytosol]
(R-HSA-2855253)
0.718
6
UniProt:P25800 LMO1
1
LMO1 [nucleoplasm]
(R-HSA-8956514)
0.718
6
UniProt:Q9NNW5 WDR6
1
WDR6 [cytosol]
(R-HSA-9715165)
0.718
6
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.671
4
UniProt:P42566-1 EPS15
0.65
4
UniProt:Q8TAA9 VANGL1
1
VANGL1 [plasma membrane]
(R-HSA-9714275)
0.649
4
UniProt:P10912 GHR
7
GHR activated [plasma membrane]
(R-HSA-1168385)
GHR(19-638) [plasma membrane]
(R-HSA-982779)
GHR(19-256) [extracellular region]
(R-HSA-1168821)
GHR(19-638) [endosome lumen]
(R-HSA-1169263)
p-5Y-GHR(19-638) [plasma membrane]
(R-HSA-1168904)
GHR(257-638) [plasma membrane]
(R-HSA-1168803)
p-Y332,Y487,Y627-GHR(19-638) [plasma membrane]
(R-HSA-1169226)
0.645
4
UniProt:Q9UQ35 SRRM2
1
SRRM2 [nucleoplasm]
(R-HSA-8865888)
0.569
3
UniProt:Q9Y597 KCTD3
1
KCTD3 [plasma membrane]
(R-HSA-9714852)
0.569
3
UniProt:Q8TBC3 SHKBP1
1
SHKBP1 [cytosol]
(R-HSA-9714849)
0.569
3
UniProt:Q96QG7 MTMR9
1
MTMR9 [cytosol]
(R-HSA-6809239)
0.556
3
UniProt:P40692 MLH1
3
MLH1 [nucleoplasm]
(R-HSA-912495)
MLH1 H329P [nucleoplasm]
(R-HSA-5444512)
MLH1 S252* [nucleoplasm]
(R-HSA-5444526)
0.556
3
UniProt:Q01664 TFAP4
0.556
3
UniProt:Q9H8W4 PKHF2
0.556
3
UniProt:Q8WV44 TRIM41
1
TRIM41 [cytosol]
(R-HSA-5688975)
0.556
3
UniProt:Q9NPJ8 NXT2
0.556
3
UniProt:Q14689-6 DIP2A
0.556
3
UniProt:Q6ZRS2-3 SRCAP
0.556
3
IntAct:EBI-16429620 CCSB ORF ID
0.556
3
UniProt:Q8TBK6 ZCH10
0.556
3
UniProt:Q5GFL6-3 VWA2
0.556
3
UniProt:Q8NEK8 TET5D
0.556
3
UniProt:P08833 IGFBP1
3
IGFBP1 [extracellular region]
(R-HSA-381513)
p-IGFBP1 [endoplasmic reticulum lumen]
(R-HSA-8957029)
IGFBP1 [endoplasmic reticulum lumen]
(R-HSA-8956699)
0.527
2
UniProt:Q14524 SCN5A
1
SCN5A [plasma membrane]
(R-HSA-443382)
0.527
2
UniProt:P11473 VDR
2
VDR [nucleoplasm]
(R-HSA-375512)
polySUMO2-VDR [nucleoplasm]
(R-HSA-4546376)
0.524
4
UniProt:P06463 VE6
0.524
4
UniProt:P55072 VCP
8
VCP [cytosol]
(R-HSA-1181251)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [extracellular region]
(R-HSA-6806191)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
Me3K315-VCP [cytosol]
(R-HSA-8932209)
0.524
2
UniProt:P31040 SDHA
2
FAD-SDHA [mitochondrial matrix]
(R-HSA-70983)
SDHA [mitochondrial matrix]
(R-HSA-9854690)
0.499
2
UniProt:Q9ULK5 VANGL2
2
VANGL2 [plasma membrane]
(R-HSA-3965373)
pS5,S82,S84-VANGL2 [plasma membrane]
(R-HSA-4551547)
0.499
2
UniProt:P23508 CRCM
0.499
2
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