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MTM1 [cytosol]
Stable Identifier
R-HSA-1604646
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
CG2
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the early endosome membrane (Homo sapiens)
MTMR12 binds MTM1 (Homo sapiens)
MTM1 [cytosol] (Homo sapiens)
MTM1:MTMR12 [cytosol] (Homo sapiens)
MTM1 [cytosol] (Homo sapiens)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Homo sapiens)
MTM1,MTMR2,MTMR4 [cytosol] (Homo sapiens)
MTM1 [cytosol] (Homo sapiens)
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Homo sapiens)
MTM1,MTMR2,MTMR4 [cytosol] (Homo sapiens)
MTM1 [cytosol] (Homo sapiens)
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Homo sapiens)
MTM1:MTMR12 [cytosol] (Homo sapiens)
MTM1 [cytosol] (Homo sapiens)
Synthesis of PIPs at the late endosome membrane (Homo sapiens)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Homo sapiens)
MTM1,MTMR2,MTMR4,MTMR7 [cytosol] (Homo sapiens)
MTM1 [cytosol] (Homo sapiens)
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Homo sapiens)
MTM1,MTMR2,MTMR4,MTMR7 [cytosol] (Homo sapiens)
MTM1 [cytosol] (Homo sapiens)
Synthesis of PIPs at the plasma membrane (Homo sapiens)
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Homo sapiens)
MTM1,MTMR1,MTMR3,MTMR6,MTMR14,SYNJ1,SYNJ2 [cytosol] (Homo sapiens)
MTM1 [cytosol] (Homo sapiens)
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Homo sapiens)
MTM1,MTMR1,MTMR3,MTMR6,MTMR14,SYNJ1,SYNJ2 [cytosol] (Homo sapiens)
MTM1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13496 MTM1
Gene Names
MTM1, CG2
Chain
chain:1-603
Reference Genes
BioGPS Gene:4534 MTM1
COSMIC (genes):MTM1 MTM1
CTD Gene:4534 MTM1
dbSNP Gene:4534 MTM1
ENSEMBL:ENSG00000171100 MTM1
ENSEMBL_homo_sapiens_GENE:ENSG00000171100.16 MTM1
HGNC:7448 MTM1
KEGG Gene (Homo sapiens):4534 MTM1
Monarch:4534 MTM1
NCBI Gene:4534 MTM1
OMIM:300415 MTM1
UCSC:Q13496 MTM1
Reference Transcript
RefSeq:NM_000252.2 MTM1
RefSeq:XM_005274687.2 MTM1
RefSeq:XM_011531173.2 MTM1
RefSeq:XM_017029550.1 MTM1
Other Identifiers
11720898_a_at
11749427_a_at
17107697
204101_3p_at
204101_PM_at
204101_at
36920_PM_at
36920_at
3994797
3994798
3994802
3994803
3994805
3994812
3994815
3994816
3994820
3994821
3994822
3994823
3994824
3994825
3994830
3994831
3994834
3994835
3994836
3994837
3994839
3994840
3994841
3994842
3994843
4534
4874998C_3p_s_at
66106_r_at
8170428
A_23_P62128
A_23_P62133
GE59185
GO:0000045
GO:0001726
GO:0003824
GO:0004438
GO:0004721
GO:0005515
GO:0005737
GO:0005768
GO:0005770
GO:0005829
GO:0005886
GO:0006470
GO:0006629
GO:0006661
GO:0006914
GO:0007005
GO:0007010
GO:0008289
GO:0008333
GO:0015031
GO:0016020
GO:0016192
GO:0016311
GO:0016787
GO:0016791
GO:0019215
GO:0023052
GO:0030017
GO:0030163
GO:0030175
GO:0031410
GO:0031674
GO:0031929
GO:0032007
GO:0032435
GO:0035091
GO:0036211
GO:0042995
GO:0043161
GO:0043226
GO:0043491
GO:0044088
GO:0045109
GO:0046716
GO:0046856
GO:0048311
GO:0048630
GO:0048633
GO:0048856
GO:0051898
GO:0052629
GO:0106018
GO:0140096
GO:1902902
HMNXSV003018606
ILMN_1686985
PH_hs_0024384
TC0X000723.hg
U46024_at
g4557895_3p_s_at
Participates
as a component of
MTM1:MTMR12 [cytosol] (Homo sapiens)
as an input of
MTMR12 binds MTM1 (Homo sapiens)
as a member of
MTM1,MTMR2,MTMR4,MTMR7 [cytosol] (Homo sapiens)
MTM1,MTMR2,MTMR4 [cytosol] (Homo sapiens)
MTM1,MTMR1,MTMR3,MTMR6,MTMR14,SYNJ1,SYNJ2 [cytosol] (Homo sapiens)
Inferred To
MTM1 [cytosol]
(Bos taurus)
MTM1 [cytosol]
(Caenorhabditis elegans)
MTM1 [cytosol]
(Canis familiaris)
MTM1 [cytosol]
(Danio rerio)
MTM1 [cytosol]
(Dictyostelium discoideum)
MTM1 [cytosol]
(Drosophila melanogaster)
MTM1 [cytosol]
(Gallus gallus)
MTM1 [cytosol]
(Schizosaccharomyces pombe)
MTM1 [cytosol]
(Sus scrofa)
YMR1 [cytosol]
(Saccharomyces cerevisiae)
Homologues of MTM1 [cytosol]
(Caenorhabditis elegans)
Homologues of MTM1 [cytosol]
(Dictyostelium discoideum)
mtm1 [cytosol]
(Xenopus tropicalis)
Mtm1 [cytosol]
(Mus musculus)
Mtm1 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
XP_016885039.1
,
XP_011529475.1
,
NP_000243.1
,
XP_005274744.1
OpenTargets
ENSG00000171100
HPA
ENSG00000171100-MTM1
GeneCards
Q13496
Ensembl
ENSP00000359423
,
ENSG00000171100
,
ENSP00000509266
,
ENST00000370396
,
ENST00000689694
,
ENSP00000508718
,
ENST00000685944
PRO
Q13496
Pharos - Targets
Q13496
Orphanet
16476
HMDB Protein
HMDBP02745
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P17661 DES
1
DES [cytosol]
(R-HSA-390570)
0.711
13
UniProt:Q15036 SNX17
0.643
3
UniProt:O00499 BIN1
1
BIN1 [cytosol]
(R-HSA-8868265)
0.602
6
UniProt:Q9C0I1 MTMR12
1
MTMR12 [cytosol]
(R-HSA-6809657)
0.571
4
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.527
2
UniProt:Q8N7C3 TRIMM
0.527
2
UniProt:O70172
2
Pip4k2a [nucleoplasm]
(R-MMU-6811484)
Pip4k2a [cytosol]
(R-MMU-1604641)
0.499
2
UniProt:P31001
1
Des [cytosol]
(R-MMU-390570)
0.463
4
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