Reactome | OGT [nucleoplasm]

OGT [nucleoplasm]

Stable Identifier

R-HSA-3321845

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit ecNumber2.4.1.255/ecNumber, OGT1_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - UCH proteinases (Homo sapiens)
      - BAP1 binds BAP1-interacting complex (Homo sapiens)
        
        BAP1-interacting complex [nucleoplasm] (Homo sapiens)
        
        BAP1-interacting core complex [nucleoplasm] (Homo sapiens)
        
        OGT [nucleoplasm] (Homo sapiens)
        
        BAP1:BAP1-interacting complex [nucleoplasm] (Homo sapiens)
        
        BAP1-interacting complex [nucleoplasm] (Homo sapiens)
        
        BAP1-interacting core complex [nucleoplasm] (Homo sapiens)
        
        OGT [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O15294 OGT

Gene Names

OGT

Chain

initiator methionine:, chain:2-1046

Reference Genes

BioGPS Gene:8473 OGT

COSMIC (genes):OGT OGT

CTD Gene:8473 OGT

dbSNP Gene:8473 OGT

ENSEMBL:ENSG00000147162 OGT

ENSEMBL_homo_sapiens_GENE:ENSG00000147162.15 OGT

HGNC:8127 OGT

KEGG Gene (Homo sapiens):8473 OGT

Monarch:8473 OGT

NCBI Gene:8473 OGT

OMIM:300255 OGT

UCSC:O15294 OGT

Reference Transcript

Other Identifiers

11732154_at

11732155_a_at

11744798_a_at

11746064_a_at

17104768

207563_PM_s_at

207563_s_at

207564_PM_x_at

207564_x_at

209240_PM_at

209240_at

212307_PM_s_at

212307_s_at

38614_s_at

39507_at

3981121

3981122

3981123

3981124

3981125

3981126

3981128

3981129

3981136

3981139

3981140

3981141

3981142

3981144

3981145

3981146

3981147

3981148

3981149

3981150

3981151

3981152

3981153

3981154

3981155

3981156

3981157

3981158

3981160

3981161

3981162

3981163

79064_at

8168316

8473

A_23_P381976

A_23_P381979

A_33_P3227284

GE56295

GE58305

GO:0000122

GO:0000123

GO:0000423

GO:0000432

GO:0003677

GO:0003824

GO:0005515

GO:0005547

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005739

GO:0005829

GO:0005886

GO:0005975

GO:0006091

GO:0006110

GO:0006111

GO:0006325

GO:0006351

GO:0006355

GO:0006357

GO:0006486

GO:0006493

GO:0006629

GO:0006914

GO:0006915

GO:0007005

GO:0007165

GO:0007584

GO:0008289

GO:0008375

GO:0012501

GO:0016020

GO:0016485

GO:0016740

GO:0016757

GO:0017122

GO:0023052

GO:0030097

GO:0030154

GO:0030163

GO:0030336

GO:0030512

GO:0031397

GO:0031490

GO:0031966

GO:0032435

GO:0032868

GO:0032922

GO:0032991

GO:0034330

GO:0035020

GO:0036211

GO:0042995

GO:0043226

GO:0044545

GO:0045202

GO:0045727

GO:0045862

GO:0045893

GO:0045944

GO:0046626

GO:0046889

GO:0048511

GO:0048856

GO:0048870

GO:0051571

GO:0051604

GO:0051963

GO:0055086

GO:0060544

GO:0071333

GO:0097363

GO:0098696

GO:0098978

GO:0120162

GO:0140096

GO:1901135

GO:1902455

GO:1902459

GO:1904263

HMNXSV003007975

Hs.100293.1.A2_3p_at

Hs.100293.2.S1_3p_a_at

ILMN_1697639

ILMN_2364828

PH_hs_0024650

TC0X000388.hg

U77413_at

g2266993_3p_a_at

Participates

as a component of

as an input of

Formation of the NSL complex (Homo sapiens)

Other forms of this molecule

OGT [cytosol]

Inferred To

Ghost homologue of OGT [nucleoplasm] (Sus scrofa)

OGT [nucleoplasm] (Bos taurus)

OGT [nucleoplasm] (Canis familiaris)

OGT [nucleoplasm] (Mus musculus)

OGT [nucleoplasm] (Rattus norvegicus)

sxc [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

XP_016885396.1, NP_858059.1, XP_016885397.1, NP_858058.1

OpenTargets

ENSG00000147162

ZINC - Substances

OGT1_HUMAN

ZINC - Biogenic

OGT1_HUMAN

ZINC target

O15294

PRO

O15294

PDB

6MA5, 4N3A, 5NPR, 4GYW, 3PE4, 4N39, 7YEA, 5NPS, 6IBO, 5HGV, 6Q4M, 3PE3, 8CM9, 7NTF, 6TKA, 5LWV, 6E37, 4CDR, 3TAX, 6EOU, 6MA1, 4XIF, 5BNW, 4GZ6, 7YEH, 4N3C, 6MA2, 4GZ5, 8FE6, 5LVV, 8FE7, 6MA3, 5VIE, 4N3B, 1W3B, 5C1D, 4XI9, 4AY6, 8FUF, 5VIF, 4GYY, 4GZ3, 4AY5, 6MA4

ZINC - Metabolites

OGT1_HUMAN

IntEnz

2.4.1.255

HPA

ENSG00000147162-OGT

GeneCards

O15294

Ensembl

ENSG00000147162, ENST00000373701, ENSP00000362805, ENSP00000362824, ENST00000373719

Pharos - Targets

O15294

ZINC - Predictions - Purchasable

OGT1_HUMAN

HMDB Protein

HMDBP01707

Interactors (38)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51610 HCFC1	2	HCFC1 [nucleoplasm] (R-HSA-1592209) K48polyUb,K63polyUb-HCFC1 [nucleoplasm] (R-HSA-5690821)	0.764	10
UniProt:Q9H1M0 N62CL			0.743	7
UniProt:O43151 TET3	1	TET3 [nucleoplasm] (R-HSA-5220918)	0.739	7
UniProt:O94763 RMP			0.674	10
UniProt:Q6N021 TET2	1	TET2 [nucleoplasm] (R-HSA-5221011)	0.659	7
UniProt:Q92560 BAP1	1	BAP1 [nucleoplasm] (R-HSA-5689665)	0.643	5
UniProt:Q9UPV9 TRAK1	3	TRAK1 [cytosol] (R-HSA-5578870) TRAK1(1-325)-RAF1(279-648) fusion [cytosol] (R-HSA-6802474) TRAK1(1-325)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802554)	0.623	3
UniProt:Q6N021-1 TET2			0.591	5
UniProt:P09022 Hoxa1	1	Hoxa1 [nucleoplasm] (R-MMU-5617924)	0.57	3
UniProt:Q9D1P2	1	KAT8 [nucleoplasm] (R-MMU-3321802)	0.564	2
UniProt:Q8NDX5 PHC3	1	PHC3 [nucleoplasm] (R-HSA-389116)	0.556	3
UniProt:P11464 PSG1	1	PSG1 [extracellular region] (R-HSA-8870766)	0.556	3
UniProt:E7EQS8 E7EQS8			0.556	3
UniProt:Q8NFU7 TET1	1	TET1 [nucleoplasm] (R-HSA-5221039)	0.527	2
UniProt:O95865 DDAH2			0.527	3
UniProt:O15047 SETD1A	1	SETD1A [nucleoplasm] (R-HSA-3239027)	0.527	2
UniProt:Q8WXF1 PSPC1			0.527	2
UniProt:O60296 TRAK2	1	TRAK2 [cytosol] (R-HSA-9693815)	0.527	3
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.527	2
UniProt:Q15291 RBBP5	1	RBBP5 [nucleoplasm] (R-HSA-1629836)	0.527	2
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.527	3
UniProt:Q9H0W7 THAP2			0.527	2
UniProt:Q96EK4 THA11			0.527	2
UniProt:Q9BTC0 DIDO1			0.527	3
UniProt:Q9Y5Z7 HCFC2	1	HCFC2 [nucleoplasm] (R-HSA-9821232)	0.527	3
UniProt:Q86X55 CARM1	1	CARM1 [nucleoplasm] (R-HSA-400139)	0.527	2
UniProt:Q9P0U4 CXXC1	1	CXXC1 [nucleoplasm] (R-HSA-535610)	0.527	2
UniProt:Q9P2N6 KANSL3	1	KANSL3 [nucleoplasm] (R-HSA-3321882)	0.527	2
UniProt:Q9UBL3 ASH2L	1	ASH2L [nucleoplasm] (R-HSA-1629834)	0.527	2
UniProt:Q8BG87 Tet3	1	Tet3 [nucleoplasm] (R-MMU-5220994)	0.524	2
UniProt:O95721 SNAP29	3	SNAP29 [azurophil granule membrane] (R-HSA-6799359) SNAP29 [plasma membrane] (R-HSA-2029020) SNAP29 [Golgi membrane] (R-HSA-6810997)	0.524	2
UniProt:O94763-1 URI1			0.524	3
UniProt:Q7Z494 NPHP3	2	MyrG2-NPHP3 [cytosol] (R-HSA-5624091) MyrG2-NPHP3 [cilium] (R-HSA-5618254)	0.508	2
UniProt:Q04206 RELA	7	MeK310-RELA [nucleoplasm] (R-HSA-8865233) p-S536-RELA [nucleoplasm] (R-HSA-9861499) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.499	2
UniProt:O95644 NFATC1	3	p-S257-NFATC1 [nucleoplasm] (R-HSA-2025935) p-S257-NFATC1 [cytosol] (R-HSA-2685618) p-12S-NFATC1 [cytosol] (R-HSA-2025953)	0.499	2
UniProt:P63088 Ppp1cc	2	Serine/threonine protein phosphatase PP1-gamma catalytic subunit [cytosol] (R-RNO-163463) PPP1CC [cytosol] (R-RNO-163443)	0.499	3
UniProt:P36873 PPP1CC	1	PPP1CC [cytosol] (R-HSA-163443)	0.499	11
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.483	2