Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
p-S183,T246-AKT1S1 [cytosol]
Stable Identifier
R-HSA-200163
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-S183,T246-PRAS40, Phospho-Proline-rich AKT1 substrate 1, AKTS1_HUMAN, AKT1S1
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by AKT1 E17K in Cancer (Homo sapiens)
AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40) (Homo sapiens)
p-S183,T246-AKT1S1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
AKT phosphorylates targets in the cytosol (Homo sapiens)
AKT phosphorylates AKT1S1 (PRAS40) (Homo sapiens)
p-S183,T246-AKT1S1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96B36 AKT1S1
Gene Names
AKT1S1, PRAS40
Chain
chain:1-256
Reference Genes
BioGPS Gene:84335 AKT1S1
COSMIC (genes):AKT1S1 AKT1S1
CTD Gene:84335 AKT1S1
dbSNP Gene:84335 AKT1S1
ENSEMBL:ENSG00000204673 AKT1S1
HGNC:28426 AKT1S1
KEGG Gene (Homo sapiens):84335 AKT1S1
Monarch:84335 AKT1S1
NCBI Gene:84335 AKT1S1
OMIM:610221 AKT1S1
UCSC:Q96B36 AKT1S1
Reference Transcript
RefSeq:NM_001278159.1 AKT1S1
RefSeq:NM_001098632.2 AKT1S1
RefSeq:NM_032375.5 AKT1S1
RefSeq:NM_001098633.3 AKT1S1
RefSeq:NM_001278160.1 AKT1S1
Other Identifiers
0002760253
11716720_a_at
11752835_a_at
11754679_a_at
1555821_3p_a_at
1555821_a_at
16874419
224982_3p_at
224982_at
3868161
3868162
3868163
3868164
3868167
3868169
3868170
3868171
3868172
3868173
3868174
3868175
3868176
3868177
3868178
3868179
3868180
3868182
3868184
3868185
3868186
48732_at
8038477
84335
89138_at
A_23_P153502
A_24_P944472
A_33_P3222451
A_33_P3344201
GE83409
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006464
GO:0006469
GO:0006950
GO:0007165
GO:0008150
GO:0008219
GO:0031931
GO:0032007
GO:0032991
GO:0042981
GO:0043226
GO:0043523
GO:0045792
GO:0048011
GO:1900034
Hs.94814.0.S1_3p_s_at
Hs2.94814.3.S1_3p_s_at
ILMN_1702729
ILMN_1726906
PH_hs_0023196
TC19001728.hg
Participant Of
output
AKT phosphorylates AKT1S1 (PRAS40)
AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)
Other forms of this molecule
AKT1S1 [nucleoplasm]
p-S183,T246-AKT1S1 [cytosol]
p-T246-AKT1S1 [cytosol]
AKT1S1 [cytosol]
Inferred To
phospho-AKT1S1 [cytosol] (Bos taurus)
phospho-AKT1S1 [cytosol] (Canis familiaris)
phospho-AKT1S1 [cytosol] (Sus scrofa)
phospho-akt1s1 [cytosol] (Danio rerio)
phospho-akt1s1 [cytosol] (Xenopus tropicalis)
phospho-Akt1s1 [cytosol] (Mus musculus)
phospho-Akt1s1 [cytosol] (Rattus norvegicus)
phospho-PRAS40 [cytosol] (Drosophila melanogaster)
Modified Residues
Name
O-phospho-L-serine at 183
Coordinate
183
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 246
Coordinate
246
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_001265089.1
,
NP_001265088.1
,
NP_115751.3
,
NP_001092103.1
,
NP_001092102.1
OpenTargets
ENSG00000204673
ZINC - Substances
AKTS1_HUMAN
GeneCards
Q96B36
HPA
ENSG00000204673-AKT1S1
ZINC target
Q96B36
Ensembl
ENST00000391831
,
ENSP00000375711
,
ENSP00000375710
,
ENST00000344175
,
ENSP00000375708
,
ENST00000391835
,
ENST00000391834
,
ENSP00000375709
,
ENSP00000341698
,
ENST00000391833
,
ENST00000391832
,
ENSG00000204673
,
ENSP00000375707
PRO
Q96B36
ZINC - Predictions - Purchasable
AKTS1_HUMAN
PDB
5WBY
,
5WBU
,
5WBL
,
6SB0
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.643
4
UniProt:Q8N122 RPTOR
3
RPTOR [cytosol]
(R-HSA-3006727)
p-S722,S792-RPTOR [cytosol]
(R-HSA-3132767)
RPTOR [nucleoplasm]
(R-HSA-5083664)
0.564
4
UniProt:P42345 MTOR
2
MTOR [cytosol]
(R-HSA-165662)
MTOR [nucleoplasm]
(R-HSA-5083674)
0.564
2
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.527
2
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text